WormBase Tree Display for Interaction: WBInteraction000541020

WBInteraction000541020 Interaction_type: Regulatory
  Interactor: Interactor_overlapping_gene: WBGene00013241 Interactor_type: Trans_regulator
      WBGene00001170 Interactor_type: Trans_regulated
      WBGene00013242 Interactor_type: Trans_regulator
    Other_interactor: ionizing radiation Interactor_type: Trans_regulator
    Variation_interactor: WBVar00241219 Interactor_type: Trans_regulator
  Interaction_summary: "To explore whether loss of UNG-1 influences stress-induced responses, we subjected the animals to ionizing radiation (IR) which generates cytosine oxidation products, such as alloxane, isodialuric acid, and 5,6-dihydrouracil, that are substrates for UNG-family enzymes [7]... fIonizing radiation induces CEP-1 dependent DNA damage induced germ-cell apoptosis through upregulation of the proapoptotic BH3 domain containing proteins egl-1 and ced-13 [30-32]. Both egl-1 and ced-13 expression were induced as measured by qRT-PCR. In agreement with the increased number of germ-cell corpses in the ung-1 mutant, induction of ced-13 expression was more pronounced in the ung-1 mutant with about 180-fold induction compared to 150-fold in the wild type (Fig. 5B)."
  Detection_method: RT_PCR
  Paper: WBPaper00036291
  Remark: Fig. 5b; "irradiated with 125 Gy in M9 buffer in an MG300 X-ray unit (Philips, Germany) operated at 10mA and 260 kV. Dose rate: 10 Gy/min (estimated with chemical (Fricke) dosimetry)."