WormBase Tree Display for Interaction: WBInteraction000542141
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| WBInteraction000542141 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00006781 | Interactor_type | Trans_regulator | |
| WBGene00002026 | Interactor_type | Trans_regulated | |||
| WBGene00002016 | Interactor_type | Trans_regulated | |||
| Interaction_summary | "Most of the negative regulators are essential, however we were able to test the effects of mutations in T24H7.2, an ER localized HSP70, and the cochaperones unc-45, sgt-1, and cyn-11, and found using qRT-PCR that the expression of endogenous HSR genes was induced (Figure 3B). We further demonstrated that this induction was tissue-selective using qRT-PCR analysis on dissected intestinal cells. We found that T24H7.2 mutant animals, but not unc-45 mutant animals, induced endogenous hsp70 in the intestine (Figure 3C)." | ||||
| Detection_method | RT_PCR | ||||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Does_not_regulate | Anatomy_term | WBbt:0005772 | ||
| Paper | WBPaper00042355 | ||||
| Remark | Fig. 3c |
