WormBase Tree Display for Interaction: WBInteraction000556862

WBInteraction000556862 Interaction_type: Regulatory: Change_of_expression_level
  Interactor: Interactor_overlapping_gene: WBGene00000296 Interactor_type: Trans_regulated
        Transgene: WBTransgene00006441
        Construct: WBCnstr00006288
      WBGene00003018 Interactor_type: Trans_regulator
    Variation_interactor: WBVar00144400 Interactor_type: Trans_regulator
  Interaction_summary: "In lin-32(e1926) males, rays lacking differentiated A- or B-type neurons (expressing cat-2 or pkd-2 reporters, respectively) are observed with significantly higher frequencies than would be expected from transgene loss alone (Fig. 3B,E). For example, in lin-32(e1926) males, ray 5 forms without a GFP-marked Atype neuron with a frequency of 26% (n=54); in wild-type, this number is 12% (n=172), presumably as a result of transgene mosaicism. Similarly, rays lack a GFP-expressing B-type neuron process with a frequency of 71% (n=122) in lin-32(e1926) males, as opposed to 19% (n=828) in wild type. We also frequently observed the reverse phenotype, namely, mature A- and B-type neurons expressing cat-2::gfp or pkd-2::gfp in the absence of their lineally related ray (Fig. 3C,F), which never occurs in wild-type animals."
  Detection_method: Construct
    Reporter_gene: [cat-2::GFP]
    Transgene
  Regulation_result: Positive_regulate: Anatomy_term: WBbt:0006971
  Paper: WBPaper00004492
  Remark: Table 2