WormBase Tree Display for Interaction: WBInteraction000557473
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| WBInteraction000557473 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00001196 | Interactor_type | Trans_regulator | |
| WBGene00006752 | Interactor_type | Trans_regulated | |||
| Interaction_summary | "We next examined presynaptic UNC-13 localization in order to monitor the regulation of the dgk-1/egl-30 pathway by AEX-1 (Nurrish et al., 1999) (Figure 6). In wild-type animals, UNC-13::GFP accumulated at a density of 1.7 puncta/10um, while, in the aex-1(sa9) mutants, UNC-13::GFP density was significantly reduced and more diffusely distributed (0.5 puncta/10um). This phenotype was rescued by introduction of both aex-1 genomic and Pmyo-3AEX-1(+) (muscle-specific expression), but not by Paex-3::AEX-1(+) (neural and intestinal expression) (Figure 6E)... Neural EGL-30(R243Q gain-of-function) also suppressed the low density of UNC-13 accumulation in the aex-1(sa9) mutant (Figure 6E), confirming that egl-30 is epistatic to aex-1." | ||||
| Detection_method | Reporter_gene | [UNC-13::GFP] | |||
| Regulation_level | Post_translational | ||||
| Regulation_result | Positive_regulate | Anatomy_term | WBbt:0005735 | ||
| Subcellular_localization | puncta | ||||
| Paper | WBPaper00005092 | ||||
| Remark | Fig. 6 |
