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WormBase Tree Display for Transgene: WBTransgene00007258

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Name Class

WBTransgene00007258Public_namecwEx333
Summary[pCAM-1, rol-6(d)]
Synonym[pCAM-1 line 2]
ConstructionConstructWBCnstr00007081
Genetic_informationExtrachromosomal
PhenotypeWBPhenotype:0000469Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Remark"Expression of wild-type CAM-1 or of any CAM-1 derivative that retained the CRD <cysteine-rich domain) caused QL descendants to reverse direction and migrate anteriorly, a phenotype not seen in cam-1 mutant animals (Fig. 4B, Table 1)... CAM-1 derivatives that lacked the CRD did not cause reversal of the direction of QL descendant migration. Therefore, it appears that overexpression of CRD causes QL descendants to reverse direction."Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Table 1Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
PenetranceIncomplete67Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Complete100Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Caused_by_geneWBGene00000289Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004993PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
WBbt:0004086PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
WBbt:0004056PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
WBbt:0004991PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
WBbt:0003832PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
WBbt:0004054PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Phenotype_assayTreatment"The percentage of QL cell descendants that were not located posterior to V4.p is presented. These represent QL descendants that have migrated anteriorly, rather than posteriorly. Because they occupy positions near each other, the data for SDQL and PVM were combined."Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
"Because they occupy positions near each other, the data for SDQR and AVM were combined and are presented in QR column. SDQR and AVM were scored as defective if their nuclei were posterior to the V2.a nucleus."Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
WBPhenotype:0000470Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Remark"Interestingly, all transgenes that encoded an intact CRD (cysteine-rich domain) (regardless of other portions that were deleted) caused a posterior shift in the average position of HSNs. Similar results were obtained when examining BDU migrations (Table 1). The posterior shift of HSN also occurred in wild-type animals bearing any of the transgenes that retained the CRD (Table 1)."Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
PenetranceIncomplete38Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Caused_by_geneWBGene00000289Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006830PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Phenotype_assayTreatment"Because HSN sometimes was misplaced anteriorly and other times was misplaced posteriorly, we present the data for both phenotypes. HSN was scored as misplaced anteriorly if its nucleus was anterior to the P5/6 nucleus and misplaced posteriorly if its nucleus was posterior to the V4 nucleus."Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000232Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
RemarkTable 1Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Caused_by_geneWBGene00000289Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006827PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Phenotype_assayTreatment"CAN was scored as defective if its nucleus was anterior to the V3 nucleus."Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
WBPhenotype:0000471Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
RemarkTable 1Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Caused_by_geneWBGene00000289Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005406PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Phenotype_assayTreatment"ALM was scored as defective if its nucleus was anterior to the V2 nucleus."Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
WBPhenotype:0000594Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
RemarkTable 1Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Caused_by_geneWBGene00000289Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006826PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Phenotype_assayTreatment"Because BDU sometimes was misplaced anteriorly and other times was misplaced posteriorly, we present the data for both phenotypes. BDU was scored as misplaced anteriorly if its nucleus was anterior to its normal position immediately anterior to V1 and misplaced posteriorly if its nucleus was posterior to the V1 nucleus."Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
ReferenceWBPaper00006269
SpeciesCaenorhabditis elegans