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WormBase Tree Display for Transgene: WBTransgene00015019

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Name Class

WBTransgene00015019Public_namewuEx187
Summary[Pftn-1::ftn-1::ftn-1 3'UTR; coel::GFP]
ConstructionConstructWBCnstr00014621
Coinjection_othercoel::GFP
Genetic_informationExtrachromosomal
PhenotypeWBPhenotype:0001236Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
RemarkThe presence of the wuEx187 [Pftn-1::ftn-1::ftn-1 3'UTR + coel::GFP] transgene resulted in increased expression of the Pftn-1::GFP transgene (data not shown)Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
Caused_by_geneWBGene00001500Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
Phenotype_assayGenotypePftn-1::GFPPaper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
WBPhenotype:0001663Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
RemarkAnimals overexpressing ftn-1 from the wuEx187 transgene [Pftn-1::ftn-1::ftn-1 3'UTR; coel::GFP] and exposed to 10 millimolar tert-butyl hydroperoxide (t-BOOH) exhibited increased life span compared to wild type worms also exposed to t-BOOH (Figure 2I, Table S7)Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
Caused_by_geneWBGene00001500Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00003239Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentAnimals were exposed to 10 millimolar tert-butyl hydroperoxide (t-BOOH) at room temperature and assayed for survivalPaper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
WBPhenotype:0002249Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
Remarkftn-1 overexpression from the wuEx187 transgene [Pftn-1::ftn-1::ftn-1 3'UTR; coel::GFP] reduced protein oxidation levels by 31% (p = 0.03) (Figures 2G, 2H).Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
Caused_by_geneWBGene00001500Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000039Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
Remarkftn-1 overexpression from the wuEx187 transgene [Pftn-1::ftn-1::ftn-1 3'UTR; coel::GFP] did not affect life span (Figure 2J).Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
Caused_by_geneWBGene00001500Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
Phenotype_assayTemperature20Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
WBPhenotype:0000673Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
RemarkOverexpression of ftn-1 from the wuEx187 [Pftn-1::ftn-1::ftn-1 3'UTR + coel::GFP] transgene did not significantly affect brood size (Figure 2F)Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
Caused_by_geneWBGene00001500Paper_evidenceWBPaper00040914
Curator_confirmedWBPerson2987
Used_forInteractorWBInteraction000517922
Associated_withStrainWBStrain00043104
ReferenceWBPaper00040914
SpeciesCaenorhabditis elegans