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WormBase Tree Display for Transgene: WBTransgene00027258

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Name Class

WBTransgene00027258Summary[Phsp::HBx; Psur-5::SUR-5::GFP]
ConstructionConstructWBCnstr00015548
CoinjectionWBCnstr00042119
Construction_summaryThe PhspHBx constructs (at 25 ng/μL each) were injected into animals with the appropriate genetic background, using Psur-5GFP (25 ng/μL) as a coinjection marker, which directs GFP expression in all somatic cells in most developmental stages (6).
Genetic_informationPhenotypeWBPhenotype:0000050Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Remark"To assess the activities of HBx inC. elegans, we induced global expression of HBx under the control of the C. elegans heat-shock promoters (PhspHBx). Expression of HBx in C. elegans had deleterious effects, leading to a high percentage of embryonic lethality (Fig. 1A and B)."Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
PenetranceHighPaper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Caused_by_otherhepatitis B virus protein HBxPaper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
WBPhenotype:0000183Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Remark"Approximately 97% of PhspHBx transgenic embryos did not hatch and were invariably deformed (Fig. 1A and B). Many contained large vacuoles that resembled necrotic cells (Fig. 1A, arrowheads) and raised discs characteristic of apoptotic cells (Fig. 1A, arrows)."Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Caused_by_otherhepatitis B virus protein HBxPaper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
WBPhenotype:0000351Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Remark"Approximately 97% of PhspHBx transgenic embryos did not hatch and were invariably deformed (Fig. 1A and B). Many contained large vacuoles that resembled necrotic cells (Fig. 1A, arrowheads) and raised discs characteristic of apoptotic cells (Fig. 1A, arrows)."Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
PenetranceHigh97%Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Caused_by_otherhepatitis B virus protein HBxPaper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
WBPhenotype:0001136Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Remark"Approximately 97% of PhspHBx transgenic embryos did not hatch and were invariably deformed (Fig. 1A and B). Many contained large vacuoles that resembled necrotic cells (Fig. 1A, arrowheads) and raised discs characteristic of apoptotic cells (Fig. 1A, arrows)."Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
PenetranceHigh97%Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Caused_by_otherhepatitis B virus protein HBxPaper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
WBPhenotype:0001395Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Remark"Approximately 97% of PhspHBx transgenic embryos did not hatch and were invariably deformed (Fig. 1A and B). Many contained large vacuoles that resembled necrotic cells (Fig. 1A, arrowheads) and raised discs characteristic of apoptotic cells (Fig. 1A, arrows)."Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Caused_by_otherhepatitis B virus protein HBxPaper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
WBPhenotype:0001397Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Remark"Approximately 97% of PhspHBx transgenic embryos did not hatch and were invariably deformed (Fig. 1A and B). Many contained large vacuoles that resembled necrotic cells (Fig. 1A, arrowheads) and raised discs characteristic of apoptotic cells (Fig. 1A, arrows)."Paper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
Caused_by_otherhepatitis B virus protein HBxPaper_evidenceWBPaper00041673
Curator_confirmedWBPerson2987
ReferenceWBPaper00041673
SpeciesCaenorhabditis elegans