WormBase Tree Display for Disease_model_annotation: WBDOannot00000764
expand all nodes | collapse all nodes | view schema
WBDOannot00000764 | Disease_term | DOID:680 | |
---|---|---|---|
Disease_of_species | Homo sapiens | ||
Modeled_by | Strain | WBStrain00047802 | |
Association_type | is_ameliorated_model_of | ||
Evidence_code | GO_code | IMP | |
ECO_term | ECO:0007013 | ||
Modifier_info | Modifier_variation | WBVar00275093 | |
Modifier_association_type | condition_ameliorated_by | ||
Genetic_sex | hermaphrodite | ||
Paper_evidence | WBPaper00041727 | ||
Disease_model_description | Transgenic expression of human Tau-337M (the 1N4R isoform of human tau with the 337M FTDP-17 mutation) in C. elegans results in movement defects, GABAergic neuronal degeneration and tau aggregation; in the strain CK1350, reduction of dopamine signaling through a mutation in one of the worm dopamine D2 receptor-like genes, dop-2(vs105) results in moderate protection against tau induced movement defects. | ||
Curator_confirmed | WBPerson324 | ||
Date_last_updated | 06 Jul 2020 00:00:00 |