WormBase Tree Display for Variation: WBVar00275093

WBVar00275093 Name: Public_name: vs105
    Other_name (12)
    HGVSg: CHROMOSOME_V:g.9609233_9609313del
  Sequence_details: SMap: S_parent: Sequence: K09G1
    Flanking_sequences: taataaaaaagtatattttcttttcaggta gtggccatcatagttatgccatacgcggtt
    Mapping_target: K09G1
    Type_of_mutation: Deletion
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain (12)
    Laboratory: LX
      CF
      IV
    Status: Live
  Affects: Gene: WBGene00001053
    Transcript: K09G1.4e.1 VEP_consequence: inframe_deletion
        VEP_impact: MODERATE
        HGVSc: K09G1.4e.1:c.175_255del
        HGVSp: CE53007:p.Ile59_Leu85del
        cDNA_position: 175-255
        CDS_position: 175-255
        Protein_position: 59-85
        Exon_number: 2/16
        Codon_change: ATAATATCAGTACTCCGGTACCGAGCACTGCAATCAGCCATCAATTTCCTTATCCTAGGCCTGGCTGTGGCGGATCTTTTG/-
        Amino_acid_change: IISVLRYRALQSAINFLILGLAVADLL/-
      K09G1.4f.1 VEP_consequence: inframe_deletion
        VEP_impact: MODERATE
        HGVSc: K09G1.4f.1:c.175_255del
        HGVSp: CE53034:p.Ile59_Leu85del
        cDNA_position: 175-255
        CDS_position: 175-255
        Protein_position: 59-85
        Exon_number: 2/15
        Codon_change: ATAATATCAGTACTCCGGTACCGAGCACTGCAATCAGCCATCAATTTCCTTATCCTAGGCCTGGCTGTGGCGGATCTTTTG/-
        Amino_acid_change: IISVLRYRALQSAINFLILGLAVADLL/-
      K09G1.4a.1 VEP_consequence: inframe_deletion
        VEP_impact: MODERATE
        HGVSc: K09G1.4a.1:c.175_255del
        HGVSp: CE35993:p.Ile59_Leu85del
        cDNA_position: 193-273
        CDS_position: 175-255
        Protein_position: 59-85
        Exon_number: 3/16
        Codon_change: ATAATATCAGTACTCCGGTACCGAGCACTGCAATCAGCCATCAATTTCCTTATCCTAGGCCTGGCTGTGGCGGATCTTTTG/-
        Amino_acid_change: IISVLRYRALQSAINFLILGLAVADLL/-
      K09G1.4g.1 VEP_consequence: inframe_deletion
        VEP_impact: MODERATE
        HGVSc: K09G1.4g.1:c.175_255del
        HGVSp: CE52992:p.Ile59_Leu85del
        cDNA_position: 191-271
        CDS_position: 175-255
        Protein_position: 59-85
        Exon_number: 3/16
        Codon_change: ATAATATCAGTACTCCGGTACCGAGCACTGCAATCAGCCATCAATTTCCTTATCCTAGGCCTGGCTGTGGCGGATCTTTTG/-
        Amino_acid_change: IISVLRYRALQSAINFLILGLAVADLL/-
      K09G1.4d.1 VEP_consequence: inframe_deletion
        VEP_impact: MODERATE
        HGVSc: K09G1.4d.1:c.175_255del
        HGVSp: CE46806:p.Ile59_Leu85del
        cDNA_position: 194-274
        CDS_position: 175-255
        Protein_position: 59-85
        Exon_number: 3/17
        Codon_change: ATAATATCAGTACTCCGGTACCGAGCACTGCAATCAGCCATCAATTTCCTTATCCTAGGCCTGGCTGTGGCGGATCTTTTG/-
        Amino_acid_change: IISVLRYRALQSAINFLILGLAVADLL/-
      K09G1.4c.1 VEP_consequence: inframe_deletion
        VEP_impact: MODERATE
        HGVSc: K09G1.4c.1:c.175_255del
        HGVSp: CE45633:p.Ile59_Leu85del
        cDNA_position: 199-279
        CDS_position: 175-255
        Protein_position: 59-85
        Exon_number: 3/17
        Codon_change: ATAATATCAGTACTCCGGTACCGAGCACTGCAATCAGCCATCAATTTCCTTATCCTAGGCCTGGCTGTGGCGGATCTTTTG/-
        Amino_acid_change: IISVLRYRALQSAINFLILGLAVADLL/-
    Interactor: WBInteraction000518035
  Genetics: Interpolated_map_position: V 2.05496
  Description: Phenotype (16)
    Phenotype_not_observed: WBPhenotype:0001006 Paper_evidence: WBPaper00044757
        Curator_confirmed: WBPerson2987
        Remark: Figure S2C Paper_evidence: WBPaper00044757
            Curator_confirmed: WBPerson2987
      WBPhenotype:0001012 Paper_evidence: WBPaper00032196
        Curator_confirmed: WBPerson712
        Remark: Animals were as susceptible to infection by P. aeruginosa as N2 animals. Paper_evidence: WBPaper00032196
            Curator_confirmed: WBPerson712
        Phenotype_assay: Strain: WBStrain00026373 Paper_evidence: WBPaper00032196
              Curator_confirmed: WBPerson712
      WBPhenotype:0001101 Paper_evidence: WBPaper00038382
        Curator_confirmed: WBPerson712
        Remark: No effects on clozapine-induced egg laying were observed. Paper_evidence: WBPaper00038382
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003634 Paper_evidence: WBPaper00038382
              Curator_confirmed: WBPerson712
      WBPhenotype:0001182 Paper_evidence: WBPaper00044757
        Curator_confirmed: WBPerson2987
        Remark: Figure 2A Paper_evidence: WBPaper00044757
            Curator_confirmed: WBPerson2987
      WBPhenotype:0001817 Paper_evidence: WBPaper00032335
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited enhanced-gustatory plasticity, i.e. strong avoidance to NaCl after starvation, similar to that observed for wild type. Paper_evidence: WBPaper00032335
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003571 Paper_evidence: WBPaper00032335
              Curator_confirmed: WBPerson712
  Disease_info: Models_disease: DOID:0050742
    Modifies_disease: DOID:680
    Models_disease_in_annotation: WBDOannot00000688
    Modifies_disease_in_annotation: WBDOannot00000764
      WBDOannot00000766
      WBDOannot00000767
  Reference: WBPaper00038382
    WBPaper00041959
    WBPaper00043908
    WBPaper00032196
    WBPaper00032335
    WBPaper00044757
    WBPaper00065340
    WBPaper00065715
  Remark: This deletion removes most of the first and second transmembrane domain and the splice acceptor for exon 2. Paper_evidence: WBPaper00024390
  Method: Deletion_allele