WormBase Tree Display for Disease_model_annotation: WBDOannot00000766
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| WBDOannot00000766 | Disease_term | DOID:680 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Strain | WBStrain00047804 | |
| Association_type | is_ameliorated_model_of | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Modifier_info | Modifier_variation | WBVar00275094 | |
| WBVar00275093 | |||
| Modifier_association_type | condition_ameliorated_by | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00041727 | ||
| Disease_model_description | Transgenic expression of human Tau-337M (the 1N4R isoform of human tau with the 337M FTDP-17 mutation) in C. elegans results in movement defects, GABAergic neuronal degeneration and tau aggregation; in the strain CK1352, reduction of dopamine signaling through a mutation in both of the worm dopamine D2 receptor-like genes, dop-2(vs105) and dop-3(vs106) results in significant protection against tau induced movement defects and reduction in tau aggregation. | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 22 Jun 2020 00:00:00 |
