WormBase Tree Display for Disease_model_annotation: WBDOannot00001290
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| WBDOannot00001290 | Disease_term | DOID:0050773 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Variation | WBVar00145572 | |
| Asserted_gene | WBGene00006433 | ||
| Association_type | is_implicated_in | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00060158 | ||
| Disease_model_description | The conserved B-subunit of succinate dehydrogenase (SDH) participates in the tricarboxylic acid cycle (TCA) cycle and mitochondrial electron transport; the Arg230His mutation in SDHB causes heritable pheochromocytoma/paraganglioma (PPGL). Null mutants of sdhb-1 in worms show arrested development and shortened lifespan. | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 21 Jul 2022 00:00:00 |
