WormBase Tree Display for Expr_pattern: Expr16429
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| Expr16429 | Expression_of | Gene | WBGene00002232 |
|---|---|---|---|
| Expression_data | GO_term | GO:0030425 | |
| GO:0030424 | |||
| GO:0016020 | |||
| Type | Reporter_gene | ||
| Pattern | We found that a functional KPC-1:: sfGFP reporter specifically expressed in PVD localized to higher-order dendritic branches of PVD neurons as well as to the PVD axonal compartment. We further found that the putative transmembrane domain of KPC-1 was necessary to direct PVD dendritic patterning because a construct lacking the predicted C-terminal transmembrane domain (S675 to S688) failed to rescue the kpc-1 mutant phenotype, whereas a construct containing a heterologous transmembrane domain of PAT-3/ β-integrin (PAT-3-TM) rescued the defects. We conclude that, in vivo, KPC-1 is localized to a membrane compartment in higher-order dendrite branches and is therefore potentially in proximity to both MNR-1 expressed by epidermal cells and the DMA-1 receptor in PVD. | ||
| Reference | WBPaper00066007 | ||
| Transgene | WBTransgene00033686 |
