WormBase Tree Display for Gene: WBGene00000231

WBGene00000231 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: D2045
  Identity: Version: 1
    Name: CGC_name: atx-2
      Sequence_name: D2045.1
      Molecular_name (12)
      Other_name: CELE_D2045.1 Accession_evidence: NDB BX284603
      Public_name: atx-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: atx
    Allele: WBVar02111582
      WBVar01500260
      WBVar01723525
      WBVar02147329
      WBVar01397273
      WBVar01397274
      WBVar00252871
      WBVar01499194
      WBVar01567371
      WBVar00856609
      WBVar00856610
      WBVar00856611
      WBVar00856612
      WBVar00856613
      WBVar00856614
      WBVar02132647
      WBVar00856615
      WBVar00856616
      WBVar00237128
      WBVar00856617
      WBVar00407376
      WBVar00407377
      WBVar00856618
      WBVar00407378
      WBVar00856619
      WBVar00856620
      WBVar00407379
      WBVar00407380
      WBVar00856621
      WBVar00407381
      WBVar00856622
      WBVar00856623
      WBVar00407382
      WBVar00407383
      WBVar00856624
      WBVar01542258
      WBVar00407384
      WBVar00856625
      WBVar00856626
      WBVar01542259
      WBVar00407385
      WBVar00856627
      WBVar00407386
      WBVar00407387
      WBVar00856628
      WBVar00856629
      WBVar00856630
      WBVar00856631
      WBVar01499774
      WBVar00856632
      WBVar00856633
      WBVar00856634
      WBVar00856635
      WBVar01499594
      WBVar00856636
      WBVar01499595
      WBVar00856637
      WBVar00856638
      WBVar00856639
      WBVar00856640
      WBVar00856641
      WBVar00856642
      WBVar00856643
      WBVar01267822
      WBVar01267826
      WBVar01267833
      WBVar01267834
      WBVar01401727
      WBVar01401729
      WBVar01995673
      WBVar00101260
      WBVar00101261
      WBVar02045689
      WBVar01793449
      WBVar00252219
      WBVar01409268
      WBVar01409269
      WBVar01332860
      WBVar01332863
      WBVar01332870
      WBVar01548857
      WBVar01416302
      WBVar02041424
      WBVar01448098
      WBVar01952617
      WBVar01939751
      WBVar00216478
      WBVar00216479
      WBVar00565096
      WBVar00216480
      WBVar00216481
      WBVar00216482
      WBVar00216483
      WBVar02144601
      WBVar00216484
      WBVar00216486
      WBVar00216487
      WBVar00178667
      WBVar00178670
      WBVar00216488
      WBVar00178671
      WBVar00178672
      WBVar00178673
      WBVar00252087
      WBVar00178674
      WBVar00178675
      WBVar00178676
      WBVar00178677
    Strain: WBStrain00007402
    RNASeq_FPKM (74)
    GO_annotation (78)
    Ortholog (35)
    Structured_description: Concise_description: atx-2 is required for early embryonic patterning; it encodes an ortholog of human ataxin-2. Paper_evidence: WBPaper00004103
            WBPaper00004612
            WBPaper00005068
            WBPaper00012788
            WBPaper00012830
            WBPaper00012882
            WBPaper00012897
            WBPaper00013003
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable mRNA binding activity. Involved in several processes, including gamete generation; positive regulation of reproductive process; and regulation of cell cycle. Located in cytoplasm. Expressed in body wall musculature; dorsal nerve cord; germ line; gonad; and ventral nerve cord. Used to study autosomal dominant cerebellar ataxia. Human ortholog(s) of this gene implicated in late onset Parkinson's disease and spinocerebellar ataxia type 2. Is an ortholog of human ATXN2 (ataxin 2) and ATXN2L (ataxin 2 like). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1441 Homo sapiens Paper_evidence: WBPaper00024364
          Curator_confirmed: WBPerson324
          Date_last_updated: 02 Aug 2013 00:00:00
    Potential_model: DOID:0050955 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10555)
      DOID:0060892 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10555)
    Disease_relevance: Human Ataxin2 (ATXN2) contains a polygutamine tract, long expansions of which cause spinocerebellar ataxia-2. Homo sapiens Paper_evidence: WBPaper00024364
          Accession_evidence: OMIM 183090
              601517
          Curator_confirmed: WBPerson324
          Date_last_updated: 02 Aug 2013 00:00:00
  Models_disease_in_annotation: WBDOannot00000221
  Molecular_info: Corresponding_CDS: D2045.1a
      D2045.1b
      D2045.1c
      D2045.1d
    Corresponding_CDS_history: D2045.1:wp132
      D2045.1:wp138
      D2045.1a:wp275
      D2045.1b:wp275
      D2045.1c:wp275
      D2045.1d:wp275
    Corresponding_transcript: D2045.1a.1
      D2045.1b.1
      D2045.1c.1
      D2045.1d.1
    Other_sequence (12)
    Associated_feature (16)
  Experimental_info: RNAi_result (46)
    Expr_pattern: Expr847
      Expr3070
      Expr4011
      Expr12343
      Expr13024
      Expr14426
      Expr14427
      Expr1016075
      Expr1030148
      Expr1147473
      Expr2009520
      Expr2027757
    Drives_construct: WBCnstr00000337
      WBCnstr00013308
      WBCnstr00037643
      WBCnstr00039983
    Construct_product: WBCnstr00037643
      WBCnstr00039241
      WBCnstr00039983
    Antibody: WBAntibody00000787
      WBAntibody00000788
    Microarray_results (29)
    Expression_cluster (120)
    Interaction (198)
  Map_info: Map: III Position: 2.51032 Error: 0.003566
    Positive: Positive_clone: D2045 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (44)
  Remark: Sequence connection from [Kiehl TR]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene