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WormBase Tree Display for Gene: WBGene00006762

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Name Class

WBGene00006762SMapS_parentSequenceY37D8A
IdentityVersion1
NameCGC_nameunc-25Person_evidenceWBPerson261
Sequence_nameY37D8A.23
Molecular_nameY37D8A.23a
Y37D8A.23a.1
CE20226
Y37D8A.23b
CE31832
Y37D8A.23c
CE32012
Y37D8A.23b.1
Y37D8A.23c.1
Other_nameCELE_Y37D8A.23Accession_evidenceNDBBX284603
Public_nameunc-25
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:42WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00143000
AlleleWBVar00093096Inferred_automaticallyFrom strain object: VC1433
WBVar01473874
WBVar00143572
WBVar01473873
WBVar02147573
WBVar00251544
WBVar02036495
WBVar02036496
WBVar02036497
WBVar01492361
WBVar01498619
WBVar02146376
WBVar02146377
WBVar02132991
WBVar02132992
WBVar02146378
WBVar00601260
WBVar02146379
WBVar00251571
WBVar02146380
WBVar02146381
WBVar02146382
WBVar02146383
WBVar01793734
WBVar01793735
WBVar01793736
WBVar00242486
WBVar01793737
WBVar01793738
WBVar01793739
WBVar01793741
WBVar01793742
WBVar01793743
WBVar00412697
WBVar01793744
WBVar00412698
WBVar00412699
WBVar01793745
WBVar01793746
WBVar00412700
WBVar00412701
WBVar01793747
WBVar00412702
WBVar01793748
WBVar01793749
WBVar00412703
WBVar01793750
WBVar00412704
WBVar00412705
WBVar00412706
WBVar00412707
WBVar00412708
WBVar00412709
WBVar00412710
WBVar01832916
WBVar01832917
WBVar01832918
WBVar01398229
WBVar01499774
WBVar01964025
WBVar01568354
WBVar01964026
WBVar01964027
WBVar00567689
WBVar01964028
WBVar02041567
WBVar01498679
WBVar00143000
WBVar00090455
WBVar02051419
WBVar01953439
WBVar00143073
WBVar01579454
WBVar01579455
WBVar01579456
WBVar01579457
WBVar01579458
WBVar00872319
WBVar00872320
WBVar00872321
WBVar02078931
WBVar00872322
WBVar00872323
WBVar00872324
WBVar00872325
WBVar00872326
WBVar00872327
WBVar00872328
WBVar00872329
WBVar00872330
WBVar01449668
WBVar00872331
WBVar00182312
WBVar01449669
WBVar00872332
WBVar00182313
WBVar00872333
WBVar00182314
WBVar00182315
WBVar00872334
WBVar00182316
WBVar00872335
WBVar00872336
WBVar00182317
WBVar00090519
WBVar00182318
WBVar00872337
WBVar00872338
WBVar00182319
WBVar00872339
WBVar00182320
WBVar00182321
WBVar00872340
WBVar00182322
WBVar00872341
WBVar00182323
WBVar00872342
WBVar00182324
WBVar00872343
WBVar00872344
WBVar00872345
WBVar00872346
WBVar00872347
WBVar00872348
WBVar00872349
WBVar00872350
WBVar00872351
WBVar00872352
WBVar00872353
WBVar00872354
WBVar00872355
WBVar01499669
WBVar00872356
WBVar01499670
WBVar00872357
WBVar00872358
WBVar00872359
WBVar00872360
WBVar00872361
WBVar00872362
WBVar00872363
WBVar00872364
WBVar00872365
WBVar01820783
WBVar00872366
WBVar00872367
WBVar00872368
WBVar00872369
WBVar00872370
WBVar00143324
WBVar00872371
WBVar00872372
WBVar00872373
WBVar01771545
WBVar00872374
WBVar00872375
WBVar00872376
WBVar00872377
WBVar00872378
WBVar01338997
WBVar00872379
WBVar01338998
WBVar01339000
WBVar02108999
WBVar01474293
Legacy_informatione156 : shrinker contracts both dorsally and ventrally when prodded; slow; poor backing; slightly small; deficient in GABA. ES3 ME2. NA4 (e265 e591).
[C.elegansII] e156 : shrinker, contracts both dorsally and ventrally when prodded; slow; loopy Fab; poor backing; slightly small; Exp defect in defecation; deficient in GABA; some neuroanatomical defects (D motorneurons). ES3 ME2. OA>5: e265, e591, sa4, sa25 (similar). Cloned: encodes 416 aa GAD (glutamic aciddecarboxylase), 45% identity to human GAD65,67. unc-25:lacZ expressed in all GABAergic neurons. [Thomas 1990; McIntire et al. 1993; CZ; JT; MT]
Strain (51)
Component_of_genotypeWBGenotype00000128
WBGenotype00000129
WBGenotype00000130
RNASeq_FPKM (74)
GO_annotation (21)
Ortholog (44)
ParalogWBGene00000239Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001839Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00004981Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00006409Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00006418Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00006562Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00007593Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00015467Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00022427Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionunc-25 encodes the C. elegans ortholog of the GABA neurotransmitter biosynthetic enzyme, glutamic acid decarboxylase (GAD); unc-25 activity is required for GABA synthesis and thus for normal synaptic transmission and GABA-mediated behaviors; UNC-25 is expressed specifically in the 26 GABAergic neurons as soon as they are generated and localizes to cell bodies, axonal branches, and synaptic regions, including some localization to synaptic vesicles; in the 19 type D GABAergic neurons, unc-25 expression is positively regulated by the UNC-30 homeodomain transcription factor, which binds to the unc-25 promoter in a sequence-specific manner.Paper_evidenceWBPaper00001759
WBPaper00003350
WBPaper00003619
Curator_confirmedWBPerson1843
Date_last_updated03 Jul 2007 00:00:00
Automated_descriptionPredicted to enable glutamate decarboxylase activity and pyridoxal phosphate binding activity. Involved in GABAergic synaptic transmission. Located in axon; perikaryon; and synapse. Expressed in EF neuron and neurons. Used to study alcohol use disorder; epilepsy; and spastic cerebral palsy. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; developmental and epileptic encephalopathy 89; and diabetes mellitus (multiple). Is an ortholog of human GAD1 (glutamate decarboxylase 1) and GAD2 (glutamate decarboxylase 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1574Homo sapiensPaper_evidenceWBPaper00045914
Curator_confirmedWBPerson324
Date_last_updated06 Jun 2019 00:00:00
DOID:1826Homo sapiensPaper_evidenceWBPaper00035198
Curator_confirmedWBPerson38202
Date_last_updated04 Jun 2018 00:00:00
DOID:0050669Homo sapiensPaper_evidenceWBPaper00024523
Accession_evidenceOMIM603513
Curator_confirmedWBPerson324
Date_last_updated22 Apr 2013 00:00:00
Potential_model (12)
Disease_relevanceMutations in Glutamic acid decarboxylase (GAD1), the human ortholog of elegans unc-25, are associated with autosomal recessive spastic cerebral palsy, a movement disorder caused by abnormalities in the brain; studies in elegans show that unc-25 is required for gamma-amino-butyric acid (GABA) synthesis and GABA-mediated behavioral functions; various GABA mutants in elegans, like unc-25, the GABA vesicular transporters (unc-46 and unc-47), and the GABA-A receptor, unc-49, all present head-bobbing convulsions.Homo sapiensPaper_evidenceWBPaper00024523
WBPaper00042136
Accession_evidenceOMIM603513
605363
Curator_confirmedWBPerson324
Date_last_updated22 Apr 2013 00:00:00
Models_disease_in_annotationWBDOannot00000163
Models_disease_assertedWBDOannot00000549
WBDOannot00000702
WBDOannot00000703
Molecular_infoCorresponding_CDSY37D8A.23a
Y37D8A.23b
Y37D8A.23c
Corresponding_transcriptY37D8A.23a.1
Y37D8A.23b.1
Y37D8A.23c.1
Other_sequence (65)
Associated_featureWBsf645681
WBsf994764
WBsf994765
WBsf1016280
WBsf1016281
WBsf1016282
WBsf225951
WBsf225952
Experimental_infoRNAi_resultWBRNAi00090105Inferred_automaticallyRNAi_primary
WBRNAi00077589Inferred_automaticallyRNAi_primary
WBRNAi00077586Inferred_automaticallyRNAi_primary
WBRNAi00027872Inferred_automaticallyRNAi_primary
WBRNAi00089945Inferred_automaticallyRNAi_primary
WBRNAi00002293Inferred_automaticallyRNAi_primary
WBRNAi00055883Inferred_automaticallyRNAi_primary
WBRNAi00090263Inferred_automaticallyRNAi_primary
WBRNAi00089782Inferred_automaticallyRNAi_primary
Expr_pattern (15)
Drives_construct (136)
Construct_productWBCnstr00010179
WBCnstr00038179
WBCnstr00038181
Regulate_expr_clusterWBPaper00065734:unc-25(e156)_downregulated
WBPaper00065734:unc-25(e156)_upregulated
Microarray_results (30)
Expression_cluster (186)
InteractionWBInteraction000000832
WBInteraction000001428
WBInteraction000002346
WBInteraction000003251
WBInteraction000003480
WBInteraction000003861
WBInteraction000005840
WBInteraction000008963
WBInteraction000008967
WBInteraction000009233
WBInteraction000028229
WBInteraction000028428
WBInteraction000028732
WBInteraction000029412
WBInteraction000030260
WBInteraction000031893
WBInteraction000038627
WBInteraction000040584
WBInteraction000041787
WBInteraction000043163
WBInteraction000045936
WBInteraction000052836
WBInteraction000052969
WBInteraction000126297
WBInteraction000126460
WBInteraction000126485
WBInteraction000126592
WBInteraction000127178
WBInteraction000165628
WBInteraction000165897
WBInteraction000165899
WBInteraction000165934
WBInteraction000166446
WBInteraction000167433
WBInteraction000220766
WBInteraction000227275
WBInteraction000299279
WBInteraction000367361
WBInteraction000376125
WBInteraction000501209
WBInteraction000501210
WBInteraction000501211
WBInteraction000501212
WBInteraction000501950
WBInteraction000517365
WBInteraction000517573
WBInteraction000520025
WBInteraction000524336
WBInteraction000551748
WBInteraction000555296
WBInteraction000558065
WBInteraction000558066
WBInteraction000580479
WBInteraction000583691
WBInteraction000584070
WBProcessWBbiopr:00000010
Map_infoMapIIIPosition20.6616Error0.04207
Well_ordered
PositivePositive_cloneY37D8AInferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point57
68
78
6019
6109
7009
7010
Multi_point (42)
Pos_neg_data354
8378
8386
8389
8550
Reference (216)
MethodGene