| WBGene00006745 | SMap | S_parent | Sequence | B0273 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-5 | Person_evidence | WBPerson261 |
| | | Sequence_name | B0273.4 |
| | | Molecular_name (19) |
| | | Other_name | CELE_B0273.4 | Accession_evidence | NDB | BX284604 |
| | | Public_name | unc-5 |
| | DB_info | Database | AceView | gene | 4G260 |
| | | | WormQTL | gene | WBGene00006745 |
| | | | WormFlux | gene | WBGene00006745 |
| | | | NDB | locus_tag | CELE_B0273.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006745|UniProtKB=Q26261 |
| | | | | family | PTHR12582 |
| | | | NCBI | gene | 177334 |
| | | | RefSeq | protein | NM_001392311.1 |
| | | | | | NM_068422.6 |
| | | | | | NM_001306822.3 |
| | | | | | NM_068421.6 |
| | | | | | NM_001306820.3 |
| | | | | | NM_001380233.1 |
| | | | SwissProt | UniProtAcc | Q26261 |
| | | | TREEFAM | TREEFAM_ID | TF316767 |
| | | | UniProt_GCRP | UniProtAcc | Q26261 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00142936 |
| | Allele (350) |
| | Legacy_information | e53 : severe coiler grows well; L1 also severe coiler; dorsal hypodermal cells abnormal dorsal nerve cord absent or almost absent cord commissures fail to reach targets muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; Egl-c. ES3 ME0. NA7 (e553 (resemble e53) e152 (weaker phenotype behaviorally and anatomically dorsal cord partially formed) etc.). |
| | | See also e2349, e2355, e2387 |
| | | [C.elegansII] e53 : severe coiler, grows well; L1 also severe coiler; dorsal hypodermal cells abnormal, dorsal nerve cord absent or almost absent, cord commissures fail to reach targets; muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; abnormal gonad arms;Egl-c. ES3 ME0. OA>10: e553 (resembles e53), e152 (weaker phenotype behaviorally and anatomically, dorsal cord partially formed), bx8, ev447,st1001tci, etc. See also unc-6, unc-40. Cloned: 3.0 and 3.1 kb transcripts (different 5') ,encode predicted 919 aa transmembrane protein,2 Ig domains and 2 TSP domains. Mosaic analysis indicates autonomous action in neurons, DTC; ectopic expression in touch cells can cause their dorsalward migration. [Hedgecock et al. 1990; Leung-Hagesteijn et al. 1992; Hamelin et al. 1993; NW] |
| | Strain (67) |
| | RNASeq_FPKM (74) |
| | GO_annotation (53) |
| | Ortholog (53) |
| | Structured_description | Concise_description | unc-5 encodes a netrin receptor; unc-5 activity is required cell autonomously for dorsalward cell and pioneer motor axon migrations along the body wall that are essential for normal locomotion and gonad development; unc-5 mRNAs are expressed throughout the entire life cycle, with increasing levels seen as animals progess to adulthood. | Paper_evidence | WBPaper00001619 |
| | | | | | WBPaper00005582 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 25 Jan 2006 00:00:00 |
| | | Automated_description | Enables netrin receptor activity and protein tyrosine kinase binding activity. Involved in several processes, including axon guidance; regulation of neuron projection development; and sex differentiation. Acts upstream of or within distal tip cell migration. Located in axonal growth cone. Expressed in several structures, including distal tip cell; excretory canal; head neurons; motor neurons; and somatic nervous system. Is an ortholog of human UNC5A (unc-5 netrin receptor A); UNC5B (unc-5 netrin receptor B); and UNC5C (unc-5 netrin receptor C). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | B0273.4a |
| | | B0273.4b |
| | | B0273.4c |
| | | B0273.4d |
| | | B0273.4e |
| | | B0273.4f |
| | Corresponding_CDS_history | B0273.4b:wp134 |
| | Corresponding_transcript | B0273.4a.1 |
| | | B0273.4b.1 |
| | | B0273.4c.1 |
| | | B0273.4d.1 |
| | | B0273.4d.2 |
| | | B0273.4e.1 |
| | | B0273.4f.1 |
| | Other_sequence | JI475712.1 |
| | | JI459463.1 |
| | | CR01727 |
| | | CRC00510_2 |
| | | CRC06468_1 |
| | | CR03346 |
| | | CJC11776_1 |
| | | JI165198.1 |
| | | Dviv_isotig23366 |
| | Associated_feature (24) |
| Experimental_info | RNAi_result (14) |
| | Expr_pattern (11) |
| | Drives_construct (17) |
| | Construct_product | WBCnstr00000353 |
| | | WBCnstr00000576 |
| | | WBCnstr00000577 |
| | | WBCnstr00005354 |
| | | WBCnstr00010750 |
| | | WBCnstr00017204 |
| | | WBCnstr00018455 |
| | | WBCnstr00019874 |
| | | WBCnstr00020677 |
| | | WBCnstr00020819 |
| | | WBCnstr00022893 |
| | | WBCnstr00034178 |
| | | WBCnstr00038762 |
| | Microarray_results (30) |
| | Expression_cluster | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1678 |
| | | WBPaper00030922:glycosylated_protein |
| | | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_embryo_enriched |
| | | WBPaper00037950:A-class-motor-neurons_embryo_SelectivelyEnriched |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_SelectivelyEnriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00048690:gonad-male-biased |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051404:alg-2(ok304)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056275:P.aeruginosa_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059754:C.neoformans_H99_upregulated |
| | | WBPaper00059754:E.faecalis_OG1RF_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AVH_parent |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:g1A_g1P |
| | | WBPaper00061340:hmc_and_homolog |
| | | WBPaper00061340:hmc_homolog |
| | | WBPaper00061340:hyp3 |
| | | WBPaper00061340:Neuroblast_I6_M5 |
| | | WBPaper00061340:SIA |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061405:S.aureus_downregulated_starvation |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061651:PDA_enriched |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065841:10_0 |
| | | WBPaper00065841:14_0 |
| | | WBPaper00065841:14_2 |
| | | WBPaper00065841:129_0 |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4386_cluster_6_3 |
| | | cgc4489_group_20 |
| | | cgc4489_male_enriched_neuronal_genes |
| | | WBPaper00005475:Aging-regulated |
| | | WBPaper00025032:cluster_12 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00035504:daf-2(e1370)_upregulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00036383:ash-2_Day8_regulated |
| | | WBPaper00038304:octr-1_regulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040963:Q50_down |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_5 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(83_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(83_min) |
| | Interaction (206) |
| | WBProcess | WBbiopr:00000025 |
| Map_info | Map | IV | Position | 1.78303 | Error | 0.002438 |
| | Well_ordered |
| | Positive | Positive_clone | B0273 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | C37G6 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | nDp5 |
| | Mapping_data | 2_point (21) |
| | | Multi_point | 95 |
| | | | 104 |
| | | | 105 |
| | | | 106 |
| | | | 117 |
| | | | 129 |
| | | | 371 |
| | | | 382 |
| | | | 768 |
| | | | 770 |
| | | | 772 |
| | | | 774 |
| | | | 776 |
| | | | 777 |
| | | | 778 |
| | | | 798 |
| | | | 799 |
| | | | 800 |
| | | | 802 |
| | | | 803 |
| | | | 804 |
| | | | 805 |
| | | | 806 |
| | | | 807 |
| | | | 808 |
| | | | 809 |
| | | | 897 |
| | | | 898 |
| | | | 905 |
| | | | 911 |
| | | | 915 |
| | | | 918 |
| | | | 919 |
| | | | 921 |
| | | | 922 |
| | | | 925 |
| | | | 927 |
| | | | 928 |
| | | | 929 |
| | | | 930 |
| | | | 931 |
| | | | 932 |
| | | | 933 |
| | | | 934 |
| | | | 935 |
| | | | 936 |
| | | | 937 |
| | | | 1114 |
| | | | 1120 |
| | | | 1122 |
| | | | 1258 |
| | | | 1259 |
| | | | 1260 |
| | | | 1267 |
| | | | 1270 |
| | | | 1287 |
| | | | 1365 |
| | | | 1511 |
| | | | 1512 |
| | | | 1522 |
| | | | 1569 |
| | | | 1709 |
| | | | 1792 |
| | | | 1793 |
| | | | 2003 |
| | | | 2006 |
| | | | 2020 |
| | | | 2023 |
| | | | 2024 |
| | | | 2237 |
| | | | 2238 |
| | | | 2827 |
| | | | 3018 |
| | | | 3019 |
| | | | 3060 |
| | | | 3061 |
| | | | 3062 |
| | | | 3135 |
| | | | 3251 |
| | | | 3576 |
| | | | 3707 |
| | | | 3716 |
| | | | 3737 |
| | | | 3781 |
| | | | 3802 |
| | | | 3809 |
| | | | 3827 |
| | | | 3828 |
| | | | 3829 |
| | | | 3943 |
| | | | 3373 |
| | | | 3372 |
| | | | 4038 |
| | | | 4614 |
| | | | 5460 |
| | | | 5708 |
| | | Pos_neg_data | 3700 |
| | | | 9031 |
| | | | 9036 |
| | | | 10892 |
| | Landmark_gene |
| Reference (341) |
| Remark | [Culotti J] The unc-5 expression pattern is now published in Su et al., Development 127,585-594 (2000) |
| Method | Gene |
