WormBase Tree Display for Gene: WBGene00004732

WBGene00004732 SMap: S_parent: Sequence: C18F3
  Identity: Version: 1
    Name: CGC_name: sax-7 Person_evidence: WBPerson42
      Sequence_name: C18F3.2
      Molecular_name (18)
      Other_name: lad-1 CGC_data_submission
        CELE_C18F3.2 Accession_evidence: NDB BX284604
      Public_name: sax-7
    DB_info: Database: WormQTL gene WBGene00004732
        WormFlux gene WBGene00004732
        NDB locus_tag CELE_C18F3.2
        NCBI gene 177602
        RefSeq protein NM_001038308.4
            NM_001038306.6
            NM_001307233.3
            NM_001038307.5
            NM_001038305.3
            NM_001307232.3
        TrEMBL UniProtAcc W6RRX6
            Q4PIU9
            W6RTH3
            Q53U86
            Q53U87
            Q18100
        UniProt_GCRP UniProtAcc Q53U87
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sax
    Allele (270)
    Strain (17)
    RNASeq_FPKM (74)
    GO_annotation (41)
    Ortholog (40)
    Paralog (24)
    Structured_description: Concise_description: sax-7 encodes an ortholog of human L1CAM, and a paralog of lad-2; L1CAM is a member of the group of highly conserved transmembrane cell adhesion receptor molecules which belong to the immunuglobulin superfamily; SAX-7 is required for axon guidance, neurite outgrowth and maintenance of neuronal positioning through homophilic and heterophilic interactions; sax-7 also affects germline development, embryonic morphogenesis, gonadal morphogenesis and tissue attachment; SAX-7 function is regulated by its physical interaction with the ankyrin UNC-44, and the gamma-syntrophin STN-2; nonphosphorylated SAX-7 is ubiquitously expressed at sites of cell-cell contact and colocalizes with UNC-44. Paper_evidence: WBPaper00004127
            WBPaper00004840
            WBPaper00026686
            WBPaper00032183
            WBPaper00025149
          Curator_confirmed: WBPerson324
            WBPerson567
          Date_last_updated: 03 Jun 2007 00:00:00
      Automated_description: Enables ankyrin binding activity. Involved in several processes, including cell development; establishment of mitotic spindle orientation; and regulation of cell morphogenesis. Located in several cellular components, including axolemma; lateral plasma membrane; and somatodendritic compartment. Expressed in several structures, including gonad; neurons; pharynx; somatic nervous system; and vulval cell. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human NFASC (neurofascin) and NRCAM (neuronal cell adhesion molecule). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:0060246
    Potential_model: DOID:5419 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1939)
  Models_disease_asserted: WBDOannot00000053
  Molecular_info: Corresponding_CDS: C18F3.2a
      C18F3.2b
      C18F3.2c
      C18F3.2d
      C18F3.2e
      C18F3.2f
    Corresponding_CDS_history: C18F3.2:wp129
      C18F3.2:wp145
    Corresponding_transcript: C18F3.2a.1
      C18F3.2b.1
      C18F3.2c.1
      C18F3.2d.1
      C18F3.2e.1
      C18F3.2f.1
    Other_sequence (58)
    Associated_feature (50)
  Experimental_info: RNAi_result: WBRNAi00101409 Inferred_automatically: RNAi_primary
      WBRNAi00040967 Inferred_automatically: RNAi_primary
      WBRNAi00110314 Inferred_automatically: RNAi_primary
      WBRNAi00011018 Inferred_automatically: RNAi_primary
      WBRNAi00001509 Inferred_automatically: RNAi_primary
    Expr_pattern (20)
    Drives_construct: WBCnstr00001457
      WBCnstr00001458
      WBCnstr00001459
      WBCnstr00001460
      WBCnstr00017300
      WBCnstr00018436
      WBCnstr00040218
      WBCnstr00041183
      WBCnstr00042159
    Construct_product: WBCnstr00011235
      WBCnstr00016127
      WBCnstr00016128
      WBCnstr00016129
      WBCnstr00016130
      WBCnstr00016131
      WBCnstr00016132
      WBCnstr00017300
      WBCnstr00018398
      WBCnstr00018434
      WBCnstr00018435
      WBCnstr00018436
      WBCnstr00020554
      WBCnstr00041185
      WBCnstr00042159
    Antibody: WBAntibody00000401
      WBAntibody00000402
      WBAntibody00000403
      WBAntibody00002176
    Microarray_results (39)
    Expression_cluster (184)
    Interaction: WBInteraction000052881
      WBInteraction000052882
      WBInteraction000135598
      WBInteraction000144317
      WBInteraction000146278
      WBInteraction000148607
      WBInteraction000153252
      WBInteraction000196385
      WBInteraction000201576
      WBInteraction000207920
      WBInteraction000211649
      WBInteraction000214673
      WBInteraction000215239
      WBInteraction000221098
      WBInteraction000236491
      WBInteraction000242647
      WBInteraction000256011
      WBInteraction000264389
      WBInteraction000264709
      WBInteraction000267443
      WBInteraction000270939
      WBInteraction000276077
      WBInteraction000283189
      WBInteraction000285735
      WBInteraction000301958
      WBInteraction000303167
      WBInteraction000309066
      WBInteraction000317394
      WBInteraction000324465
      WBInteraction000335803
      WBInteraction000339916
      WBInteraction000342136
      WBInteraction000346463
      WBInteraction000349311
      WBInteraction000350969
      WBInteraction000356031
      WBInteraction000363522
      WBInteraction000365362
      WBInteraction000366021
      WBInteraction000372655
      WBInteraction000372934
      WBInteraction000375276
      WBInteraction000380846
      WBInteraction000395604
      WBInteraction000402201
      WBInteraction000416229
      WBInteraction000416869
      WBInteraction000422036
      WBInteraction000423789
      WBInteraction000434156
      WBInteraction000437836
      WBInteraction000448347
      WBInteraction000518965
      WBInteraction000522413
      WBInteraction000524604
      WBInteraction000524605
      WBInteraction000524606
      WBInteraction000540821
      WBInteraction000540837
      WBInteraction000541909
      WBInteraction000542793
      WBInteraction000542998
      WBInteraction000543027
      WBInteraction000543028
      WBInteraction000544010
      WBInteraction000544011
      WBInteraction000544012
      WBInteraction000544013
      WBInteraction000544014
      WBInteraction000544015
      WBInteraction000544016
      WBInteraction000544017
      WBInteraction000546912
      WBInteraction000549512
      WBInteraction000552913
      WBInteraction000554722
      WBInteraction000554724
      WBInteraction000555491
      WBInteraction000556215
      WBInteraction000556216
      WBInteraction000556217
      WBInteraction000556218
      WBInteraction000556219
      WBInteraction000556629
      WBInteraction000556630
      WBInteraction000557068
      WBInteraction000557069
      WBInteraction000559972
      WBInteraction000559982
      WBInteraction000559983
      WBInteraction000559984
      WBInteraction000560778
      WBInteraction000569220
      WBInteraction000574206
      WBInteraction000579125
      WBInteraction000579127
      WBInteraction000579128
      WBInteraction000583783
      WBInteraction000584172
    WBProcess: WBbiopr:00000073
  Map_info: Map: IV Position: 3.5916 Error: 0.001877
    Positive: Positive_clone: C18F3 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4049
        4986
        4999
        5613
  Reference (102)
  Remark: Description and Allele (ky146) data extracted from Zallen JA, Kirch SA, Bargmann CI [ck1 020828]
    Sequence connection from [Chen L, Bennett V]
    lad-1 was merged into this gene following advice from the CGC [030902 krb]
  Method: Gene