WBGene00006809 | SMap | S_parent | Sequence | C11D2 |
| Identity | Version | 2 |
| | Name | CGC_name | unc-77 | Person_evidence | WBPerson261 |
| | | Sequence_name | C11D2.6 |
| | | Molecular_name (48) |
| | | Other_name | nca-1 | Paper_evidence | WBPaper00031592 |
| | | | | Person_evidence | WBPerson604 |
| | | | CELE_C11D2.6 | Accession_evidence | NDB | BX284604 |
| | | Public_name | unc-77 |
| | DB_info | Database | WormQTL | gene | WBGene00006809 |
| | | | WormFlux | gene | WBGene00006809 |
| | | | NDB | locus_tag | CELE_C11D2.6 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006809|UniProtKB=V6CKM5 |
| | | | | family | PTHR46141 |
| | | | NCBI | gene | 177379 |
| | | | RefSeq | protein (16) |
| | | | TREEFAM | TREEFAM_ID | TF312843 |
| | | | TrEMBL | UniProtAcc | V6CKL6 |
| | | | | | V6CLY7 |
| | | | | | V6CLZ1 |
| | | | | | V6CLY1 |
| | | | | | V6CJF9 |
| | | | | | V6CLT6 |
| | | | | | U4PMX5 |
| | | | | | Q8MXH5 |
| | | | | | V6CKM5 |
| | | | | | U4PCH9 |
| | | | | | V6CLU1 |
| | | | | | V6CLY6 |
| | | | | | Q688B2 |
| | | | | | Q688B3 |
| | | | | | Q688B4 |
| | | | | | V6CJF5 |
| | | | UniProt_GCRP | UniProtAcc | V6CKM5 |
| | | | OMIM | gene | 611549 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 03 Dec 2009 11:55:50 | WBPerson2970 | Event | Acquires_merge | WBGene00003557 |
| | | Acquires_merge | WBGene00003557 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143348 |
| | Allele (298) |
| | Legacy_information | e625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1. |
| | | [C.elegansII] e625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1. [Brenner 1974] |
| | Strain | WBStrain00035028 |
| | | WBStrain00035029 |
| | | WBStrain00035482 |
| | | WBStrain00040855 |
| | | WBStrain00040862 |
| | | WBStrain00040863 |
| | | WBStrain00040864 |
| | | WBStrain00040865 |
| | | WBStrain00006352 |
| | Component_of_genotype | WBGenotype00000089 |
| | | WBGenotype00000090 |
| | | WBGenotype00000091 |
| | RNASeq_FPKM (74) |
| | GO_annotation (18) |
| | Ortholog (51) |
| | Paralog | WBGene00003558 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000367 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00001187 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00006742 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00008911 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | unc-77 encodes, along with nca-2, one of two C. elegans alpha-1-like subunits of a voltage-insensitive cation leak channel related to Drosophila narrow abdomen and the vertebrate Vgcnl1/NALCN proteins; unc-77 functions redundantly with nca-2 to transmit depolarization signals from neuronal cell bodies to axons, thus regulating presynaptic activation; unc-77 and nca-2 are also required for normal locomotion and the response to specific volatile anesthetics; in regulating synaptic activity, unc-77 appears to function in the same pathway as unc-79 and unc-80, which encode novel conserved proteins that reciprocally regulate UNC-77 expression; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-77::gfp reporter fusion is expressed in many sensory and all motoneurons; in the dorsal and ventral nerve cords, UNC-77 localizes to specific axonal regions, but not to synapses. | Paper_evidence | WBPaper00030757 |
| | | | | | WBPaper00031000 |
| | | | | | WBPaper00031592 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 22 Jun 2010 00:00:00 |
| | | Automated_description | Enables monoatomic cation channel activity. Involved in positive regulation of GABAergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and positive regulation of locomotion. Located in axon. Expressed in cholinergic neurons; nerve ring; pharyngeal neurons; and tail ganglion. Used to study congenital limbs-face contractures-hypotonia-developmental delay syndrome. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Is an ortholog of human NALCN (sodium leak channel, non-selective). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:0081048 | Homo sapiens | Paper_evidence | WBPaper00046648 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 09 Feb 2022 00:00:00 |
| | Potential_model | EFO:MONDO:0014176 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19082) |
| | | DOID:0081048 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19082) |
| Models_disease_asserted | WBDOannot00001101 |
| | WBDOannot00001105 |
| Molecular_info | Corresponding_CDS (16) |
| | Corresponding_CDS_history | C11D2.6a:wp239 |
| | | C11D2.6b:wp239 |
| | | C11D2.6c:wp239 |
| | Corresponding_transcript (16) |
| | Other_sequence (15) |
| | Associated_feature | WBsf651837 |
| | | WBsf996705 |
| | | WBsf996706 |
| | | WBsf996707 |
| | | WBsf996708 |
| | | WBsf996709 |
| | | WBsf1017492 |
| | | WBsf1017493 |
| | | WBsf230141 |
| | | WBsf230142 |
| Experimental_info | RNAi_result (15) |
| | Expr_pattern | Chronogram197 |
| | | Expr4860 |
| | | Expr5240 |
| | | Expr8058 |
| | | Expr8060 |
| | | Expr8194 |
| | | Expr8324 |
| | | Expr1144413 |
| | | Expr2017906 |
| | | Expr2036042 |
| | Drives_construct (12) |
| | Construct_product | WBCnstr00017151 |
| | | WBCnstr00021676 |
| | | WBCnstr00021677 |
| | | WBCnstr00021678 |
| | | WBCnstr00021679 |
| | | WBCnstr00021680 |
| | | WBCnstr00021681 |
| | | WBCnstr00037886 |
| | Antibody | WBAntibody00001260 |
| | | WBAntibody00001384 |
| | Microarray_results (48) |
| | Expression_cluster | WBPaper00032425:down_in_zfp-1 |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_embryo_enriched |
| | | WBPaper00037950:AVE-neuron_embryo_enriched |
| | | WBPaper00037950:AVE-neuron_embryo_SelectivelyEnriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042194:nhr-114(RNAi)_downregulated |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:tunicamycin_downregulated |
| | | WBPaper00045809:rsd-2(yp10)_downregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set1 |
| | | WBPaper00048690:gonad-male-biased |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00051265:F4_hrde-1(tm1200)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_downregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055137:S.maltophilia_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00055827:daf-2(e1370)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:gut-microbiota_downregulated |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_upregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059754:P.aeruginosa_PA14_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061274:hypergravity_15xg_downregulated |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVG |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RID |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RIS |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:C25E10.11-F35H12.1 |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061527:xbx-3-DH11.5_20397 |
| | | WBPaper00061651:AS_enriched |
| | | WBPaper00061651:AVG_enriched |
| | | WBPaper00061651:DA9_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065841:6_0 |
| | | WBPaper00065841:6_1 |
| | | WBPaper00065841:6_2 |
| | | WBPaper00065841:6_3 |
| | | WBPaper00065841:14_0 |
| | | WBPaper00065841:14_1 |
| | | WBPaper00065841:14_2 |
| | | WBPaper00065841:28_0 |
| | | WBPaper00065841:29_0 |
| | | WBPaper00065841:46_0 |
| | | WBPaper00065841:51_0 |
| | | WBPaper00065841:51_1 |
| | | WBPaper00065841:60_0 |
| | | WBPaper00065841:61_0 |
| | | WBPaper00065841:68_1 |
| | | WBPaper00065841:91_0 |
| | | WBPaper00065841:94_0 |
| | | WBPaper00065841:98_0 |
| | | WBPaper00065841:103_0 |
| | | WBPaper00065841:111_0 |
| | | WBPaper00065841:115_0 |
| | | WBPaper00065841:120_0 |
| | | WBPaper00065841:122_0 |
| | | WBPaper00065841:129_0 |
| | | WBPaper00065841:131_0 |
| | | WBPaper00065841:136_0 |
| | | WBPaper00065841:138_0 |
| | | WBPaper00065841:139_0 |
| | | WBPaper00065841:144_0 |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | cgc4489_group_5 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042067:Cu2+_upregulated_kgb-1_top66 |
| | | WBPaper00042067:Cu2+_upregulated_WT |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00045960:L1-L4-lethargus_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (21) |
| Map_info | Map | IV | Position | 3.08555 |
| | Positive | Positive_clone | C11D2 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 323 |
| | | Multi_point | 1422 |
| | | | 4509 |
| Reference (42) |
| Method | Gene |