| WBGene00004879 | SMap | S_parent | Sequence | C48B6 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | smg-1 | Person_evidence | WBPerson261 |
| | | Sequence_name | C48B6.6 |
| | | Molecular_name | C48B6.6a |
| | | | C48B6.6a.1 |
| | | | CE30258 |
| | | | C48B6.6b |
| | | | CE53740 |
| | | | C48B6.6b.1 |
| | | Other_name | mab-1 |
| | | | CELE_C48B6.6 | Accession_evidence | NDB | BX284601 |
| | | Public_name | smg-1 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | smg |
| | Reference_allele | WBVar00143847 |
| | Allele (147) |
| | Legacy_information | e1228 : adult male has swollen bursa ES3 (adult male) ME1. Adult hermaphrodite has protruding vulva. ES2. NA4 (e1233 e2134spo : similar phenotype). |
| | | See also e1228, e1229, e1233, e2134, e2263, ma127, ma129, ma131 |
| | | [C.elegansII] e1228 : adult male has swollen bursa.ES3 (adult male) ME1. Adult hermaphrodite has protruding vulva. ES2. Recessive suppressor of unc-54(r293), tra-2(e1209), etc. unc-54 nonsense RNAs accumulate.OA>10: e1233, e2134spo (similar phenotypes), ma127, ma131, r861, r913spo, etc. Cloned: 7.8 kb transcript, encodes predicted protein with some kinase similarity in C-term. [Hodgkin et al. 1989; Pulak and Anderson 1993; TR] |
| | Complementation_data | [Pulak R] complements n2088 |
| | Strain (23) |
| | RNASeq_FPKM (74) |
| | GO_annotation (26) |
| | Ortholog (36) |
| | Paralog | WBGene00000226 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000227 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002583 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00007028 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | smg-1 encodes a phosphatidylinositol kinase-related protein kinase; SMG-1 functions as a key component of the nonsense-mediated mRNA decay (NMD) pathway that identifies and degrades mRNAs that contain premature stop codons; in addition, and partially in parallel to DAF-2-insulin signaling, SMG-1 regulates adult lifespan and the response to oxidative stress; in vitro, SMG-1 is capable of phosphorylating SMG-2/UPF1, an RNA helicase whose activity is also required for NMD and with which SMG-1 coimmunoprecipitates from crude extracts. | Paper_evidence | WBPaper00024418 |
| | | | | | WBPaper00032237 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 07 Oct 2008 00:00:00 |
| | | Automated_description | Predicted to enable protein serine/threonine kinase activity. Involved in male genitalia development; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and obsolete hermaphrodite genitalia development. Predicted to be located in nucleus. Predicted to be part of TORC1 complex and TORC2 complex. Is an ortholog of human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C48B6.6a |
| | | C48B6.6b |
| | Corresponding_CDS_history | C48B6.6:wp126 |
| | | C48B6.6b:wp273 |
| | Corresponding_transcript | C48B6.6a.1 |
| | | C48B6.6b.1 |
| | Other_sequence (18) |
| | Associated_feature | WBsf664370 |
| | | WBsf664371 |
| | | WBsf664372 |
| | | WBsf664373 |
| | | WBsf984028 |
| | | WBsf1010005 |
| | | WBsf219650 |
| | | WBsf219651 |
| Experimental_info | RNAi_result (20) |
| | Expr_pattern | Expr1024290 |
| | | Expr1032418 |
| | | Expr1146716 |
| | | Expr2015907 |
| | | Expr2034140 |
| | Construct_product | WBCnstr00007260 |
| | Regulate_expr_cluster | WBPaper00053308:NMD(-)_downregulated_SMD-2_non-binding_ClassIV |
| | | WBPaper00053308:NMD(-)_upregulated_SMD-2_non-binding_ClassIII |
| | Antibody | WBAntibody00000757 |
| | | WBAntibody00002206 |
| | Microarray_results (29) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:all-neurons_embryo_enriched |
| | | WBPaper00037950:AVA-neuron_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00040420:ALM_PLM_enriched |
| | | WBPaper00042561:smg-2(RNAi)_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(gk119)_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_upregulated_ClassI |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061527:gpb-1_3783-C48A7.2_22459 |
| | | WBPaper00061527:npp-8_4355-afd-1_4796 |
| | | WBPaper00061527:trcs-2_5724-R11A8.7_17645 |
| | | WBPaper00061753:csr-1(tor159)_downregulated_20C |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062056:lin-36(we31)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | cgc4489_group_2 |
| | | cgc4489_group_9 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_39 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00038231:Cry5B_1.5-fold_upregulated |
| | | WBPaper00040823:alg-1(gk214)_downregulated |
| | | WBPaper00041002:HF_3d_0.2mM_Down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00055435:AuNPs_downregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (70) |
| Map_info | Map | I | Position | 1.48161 | Error | 0.009583 |
| | Well_ordered |
| | Positive | Positive_clone | C48B6 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | F56F2 |
| | Mapping_data (2) |
| Reference (133) |
| Remark | [Pulak R] n2088 may be a deficiency, nDf48 |
| | Sequence connection from [O'Connor SL, Anderson RP] based on EMBL:AF149821 |
| Method | Gene |
