WBGene00006749 | SMap | S_parent | Sequence | CHROMOSOME_X |
| Identity | Version | 1 |
| | Name | CGC_name | unc-9 | Person_evidence | WBPerson261 |
| | | Sequence_name | R12H7.1 |
| | | Molecular_name | R12H7.1a |
| | | | R12H7.1a.1 |
| | | | CE28246 |
| | | | R12H7.1b |
| | | | CE51729 |
| | | | R12H7.1a.2 |
| | | | R12H7.1b.1 |
| | | Other_name | CELE_R12H7.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | unc-9 |
| | DB_info | Database | AceView | gene | XN833 |
| | | | WormQTL | gene | WBGene00006749 |
| | | | WormFlux | gene | WBGene00006749 |
| | | | NDB | locus_tag | CELE_R12H7.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006749|UniProtKB=O01393 |
| | | | | family | PTHR11893 |
| | | | NCBI | gene | 181443 |
| | | | RefSeq | protein | NM_001330917.4 |
| | | | | | NM_171790.8 |
| | | | SwissProt | UniProtAcc | O01393 |
| | | | TrEMBL | UniProtAcc | A0A1C3NSM1 |
| | | | UniProt_GCRP | UniProtAcc | O01393 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00142960 |
| | Allele (304) |
| | Legacy_information | e101 : moves backward better than forward slight kinker in forward movement active healthy; larvae more severely uncoordinated; male fan slightly reduced spicules tend to protrude. ES2 ME0. NA2 (e111). |
| | | [C.elegansII] e101 : moves backward better than forward slight kinker in forward movement active healthy; larvae more severely uncoordinated; suppresses anaesthetic hypersensitivity of unc-79 and unc-80; male fan slightly reduced, spicules tend to protrude. ES2 ME0. OA3: e101, ec27, bx5, e111. Cloned: cosmid rescue (R12H7). [Brenner 1974; Morgan and Sedensky 1994; CW; MQ] |
| | Strain (29) |
| | RNASeq_FPKM (74) |
| | GO_annotation (27) |
| | Ortholog (35) |
| | Paralog (24) |
| | Structured_description | Concise_description | unc-9 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; UNC-9 is required for normal forward locomotion and egg-laying and also plays a role in the response to antihelminthics and volatile anesthetics; UNC-9 may form a functional pair with UNC-7, another C. elegans innexin, as mutations in unc-7 result in defects nearly identical to those in unc-9 mutant animals. | Paper_evidence | WBPaper00002950 |
| | | | | | WBPaper00004670 |
| | | | | | WBPaper00005286 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables actin filament binding activity and gap junction channel activity. Involved in monoatomic ion transmembrane transport and positive regulation of locomotion. Located in gap junction. Expressed in several structures, including anchor cell; muscle cell; neurons; phasmid sheath cell; and somatic nervous system. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | R12H7.1a |
| | | R12H7.1b |
| | Corresponding_CDS_history | R12H7.1:wp52 |
| | Corresponding_transcript | R12H7.1a.1 |
| | | R12H7.1a.2 |
| | | R12H7.1b.1 |
| | Other_sequence (38) |
| | Associated_feature (22) |
| Experimental_info | RNAi_result | WBRNAi00089959 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027706 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00101970 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090119 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00101969 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00101971 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00051863 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090277 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089762 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00005223 |
| | | WBCnstr00011756 |
| | | WBCnstr00012540 |
| | | WBCnstr00013463 |
| | | WBCnstr00016962 |
| | | WBCnstr00018785 |
| | | WBCnstr00019879 |
| | | WBCnstr00034174 |
| | | WBCnstr00042717 |
| | Construct_product | WBCnstr00004912 |
| | | WBCnstr00007077 |
| | | WBCnstr00014822 |
| | | WBCnstr00017891 |
| | | WBCnstr00018129 |
| | | WBCnstr00019880 |
| | | WBCnstr00021094 |
| | | WBCnstr00022772 |
| | | WBCnstr00022774 |
| | | WBCnstr00034174 |
| | Antibody | WBAntibody00001277 |
| | | WBAntibody00001907 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00005700:transmembrane_protein |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_CoreEnriched |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040420:FLP_enriched |
| | | WBPaper00040560:hpl-2_embryo_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_tiling |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050163:let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050163:let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:hmc |
| | | WBPaper00061340:hmc_homolog |
| | | WBPaper00061340:mu_int_mu_anal |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SMD |
| | | WBPaper00061405:S.aureus_downregulated_starvation |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:kin-29_2839-unc-9_3883 |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061651:DA9_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:MC_enriched |
| | | WBPaper00061651:URB_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VC_4_5_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065841:108_0 |
| | | WBPaper00065841:118_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00066110:Cisplatin_upregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_15 |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Serratia_marcesens_downregulated |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00038304:octr-1_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00042274:tbx-2(bx59)_upregulated |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (65) |
| Map_info | Map | X | Position | 10.2432 | Error | 0.033106 |
| | Well_ordered |
| | Positive | Inside_rearr | yDp4 |
| | | | yDp5 |
| | | | yDp6 |
| | | | yDp7 |
| | | | yDp8 |
| | | | yDp9 |
| | | | yDp10 |
| | | | yDp11 |
| | | | yDp12 |
| | | Positive_clone | R12H7 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point (15) |
| | | Multi_point (65) |
| | | Pos_neg_data (29) |
| | Landmark_gene |
| Reference (101) |
| Method | Gene |