| WBGene00006768 | SMap | S_parent | Sequence | ZK637 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-32 | Person_evidence | WBPerson261 |
| | | Sequence_name | ZK637.8 |
| | | Molecular_name (18) |
| | | Other_name | CELE_ZK637.8 | Accession_evidence | NDB | BX284603 |
| | | Public_name | unc-32 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143023 |
| | Allele (71) |
| | Possibly_affected_by | WBVar02157789 |
| | | WBVar02157790 |
| | Legacy_information | e189 : severe coiler little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c. ES3 ME0 NA1 (rare mutation). |
| | | [Thierry-Mieg] |
| | | See also eIs16, f120, f121, f123 |
| | | [C.elegansII] e189 : severe coiler, little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c; Ric. ES3 ME0. OA>5: f123 (lethal, f123/e189 coiler),f121 (lethal, f121/e189 almost WT), ut61, ut111(embryonic lethals, irregular shape). Most alleles lethal. Cloned: probably encodes protein with homology to glutathione reductase (ZK637.10); downstream gene in operon. [Brenner 1974; Nguyen et al. 1995; FF; JC] |
| | Strain (305) |
| | RNASeq_FPKM (74) |
| | GO_annotation (28) |
| | Contained_in_operon | CEOP3556 |
| | Ortholog (59) |
| | Paralog | WBGene00043993 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes |
| | | WBGene00006916 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006915 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006914 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | unc-32 encodes, by alternative splicing, six isoforms of an ortholog of subunit a of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); UNC-32 is orthologous to human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutated in distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated in osteopetrosis); one UNC-32 isoform is essential for locomotion and normal synaptic vesicle morphology in motoneurons, is expressed solely in the nervous system, and is specifically mutated by unc-32(e189) or unc-32(f120); other UNC-32 isoforms are essential for embryonic and larval development; UNC-32 is expressed throughout the life cycle, strongly in the nervous system, but also in vulvae, spermathecal-uterine valves, intestine, and pharynx; UNC-32 is required for necrosis, since mutations of unc-32 suppress necrotic neurodegeneration and thapsigargin-induced cell death; in S. cerevisiae, different V0 a-subunits (Stv1p and Vph1p) direct the assembly of V-ATPases to different membranes and organelles, suggesting that the profusion of such subunits in C. elegans (co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have a similar function; alternative splicing of the unc-32 pre-mRNA is dependent on ASD-1 and FOX-1, and in neurons, is also dependent on UNC-75, which binds unc-32 intron 7a in vitro. | Paper_evidence | WBPaper00004601 |
| | | | | | WBPaper00004842 |
| | | | | | WBPaper00025183 |
| | | | | | WBPaper00028773 |
| | | | | | WBPaper00028774 |
| | | | | | WBPaper00028775 |
| | | | | | WBPaper00042088 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 26 Mar 2013 00:00:00 |
| | | Automated_description | Predicted to enable ATPase binding activity. Involved in several processes, including cholinergic synaptic transmission; defense response to Gram-positive bacterium; and positive regulation of neurotransmitter secretion. Part of vacuolar proton-transporting V-type ATPase complex. Expressed in several structures, including alimentary muscle; hermaphrodite gonad; neurons; somatic nervous system; and vulva. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and developmental and epileptic encephalopathy 104. Is an ortholog of human ATP6V0A1 (ATPase H+ transporting V0 subunit a1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0070390 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:865) |
| | | DOID:0110942 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11647) |
| | | DOID:14219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:866) |
| | | DOID:0112171 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18481) |
| | | EFO:MONDO:0015827 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:866) |
| | | DOID:0070134 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18481) |
| Molecular_info | Corresponding_CDS | ZK637.8a |
| | | ZK637.8b |
| | | ZK637.8c |
| | | ZK637.8d |
| | | ZK637.8e |
| | | ZK637.8f |
| | Corresponding_CDS_history | ZK637.8a:wp77 |
| | | ZK637.8b:wp77 |
| | Corresponding_transcript | ZK637.8a.1 |
| | | ZK637.8b.1 |
| | | ZK637.8c.1 |
| | | ZK637.8d.1 |
| | | ZK637.8e.1 |
| | | ZK637.8f.1 |
| | Other_sequence (98) |
| | Associated_feature (12) |
| Experimental_info | RNAi_result (28) |
| | Expr_pattern (9) |
| | Drives_construct | WBCnstr00000434 |
| | | WBCnstr00006396 |
| | | WBCnstr00010008 |
| | | WBCnstr00010009 |
| | | WBCnstr00010814 |
| | | WBCnstr00013318 |
| | | WBCnstr00017554 |
| | Construct_product | WBCnstr00000434 |
| | | WBCnstr00006396 |
| | | WBCnstr00014414 |
| | | WBCnstr00015831 |
| | | WBCnstr00017091 |
| | | WBCnstr00017553 |
| | | WBCnstr00041445 |
| | Microarray_results (39) |
| | Expression_cluster | WBPaper00005700:transmembrane_protein |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045303:ZK1236.1(tm4178)_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050468:hlh-30-dependent_Cry5B_regulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:cytoplasm_specific |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_specific |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055969:electromagnetic-field_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:pm8 |
| | | WBPaper00061527:tars-1-AFFX-r2-3026-5_at |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:PDE_enriched |
| | | WBPaper00061651:RME_DV_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VC_4_5_enriched |
| | | WBPaper00062056:lin-36(we31)_upregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064624:iHg-induced_aggregome |
| | | WBPaper00064735:bet-1(uth41)_vs_N2_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065623:128 |
| | | WBPaper00065841:118_0 |
| | | cgc4386_cluster_5_5 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_58 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5 |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00048563:L1_DD_enriched |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction (84) |
| Map_info | Map | III | Position | 0 |
| | Well_ordered |
| | Positive | Inside_rearr | mnDp37 |
| | | Positive_clone | A1D10 |
| | | | A1F1 |
| | | | T05B2 |
| | | | ZK637 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | tnDf2 |
| | Mapping_data | 2_point (34) |
| | | Multi_point (263) |
| | | Pos_neg_data | 806 |
| | | | 3726 |
| | | | 8637 |
| | | | 8642 |
| | | | 9451 |
| | Landmark_gene |
| Reference (150) |
| Method | Gene |
