WBGene00006801 | SMap | S_parent | Sequence | CHROMOSOME_V |
| Identity | Version | 2 |
| | Name | CGC_name | unc-68 | Person_evidence | WBPerson261 |
| | | Sequence_name | K11C4.5 |
| | | Molecular_name (48) |
| | | Other_name | ryr-1 |
| | | | kra-1 |
| | | | CELE_K11C4.5 | Accession_evidence | NDB | BX284605 |
| | | Public_name | unc-68 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 07 Nov 2007 17:12:59 | WBPerson2970 | Event | Acquires_merge | WBGene00021962 |
| | | Acquires_merge | WBGene00021962 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143286 |
| | Allele (351) |
| | Legacy_information | See also e2313 |
| | | [Kagawa H] pka ryr-1, for ryanodine receptor. 46 exons, encodes 5071 aa predicted protein. e540 (Unc-68) is intron 21 splice acceptor mutation, probable null. Weak allele kh30 (pka kra-1) exhibits ketamine-dependent convulsions followed by paralysis, mutation is S1444N change at putative PKC phosphorylation site. |
| | | [C.elegansII] e540 : weak kinker, slow, thin; slight shrinker; head region but not body resistant to 1 mM levamisole, ouabain. ES3. ME2. OA>15: x14, x24, e932, e2313,s92spo, r1162 (presumed null, deletes all TM domains) etc.(all resemble e540). Cloned: 30 kb gene, 43 exons, encodes 4902 aa ryanodine receptor (43% identity to mammalian cardiac RYR). [Brenner 1974; Lewis et al. 1980; HK; TR] |
| | | [C.elegansII] kh30 : semidominant convulsive behavior in 30mM ketamine or other NMDA antagonists; recessive cs Unc; variable motility; weakly resistant to cholinergic agonists, ouabain;normal muscle morphology. [HK] |
| | Complementation_data | [Kagawa H] fails to complement kh30 (pka kra-1) |
| | Strain (21) |
| | RNASeq_FPKM (74) |
| | GO_annotation (28) |
| | Ortholog (67) |
| | Paralog | WBGene00002173 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | unc-68 encodes a ryanodine receptor ortholog that is expressed in body-wall muscle cells and is required for normal body tension and locomotion; unc-68 mutants are flaccid, sluggish, and resistant to ryanodine, but have normal muscle ultrastructure; UNC-68 is dispensable for excitation-contraction coupling itself, but may amplify its calcium signals; the unc-68/kra-1(kh30) mutation is an S1444N substitution at a putative protein kinase C phosphorylation site; UNC-68 reduced unc-103(sy557)-induced spicule protraction by one half; unc-68 is orthologous to the human genes RYR1 (OMIM:180901, mutated in malignant hyperthermia and central core disease), RYR2 (OMIM:180902, mutated in stress-induced polymorphic ventricular tachycardia), and RYR3 (OMIM:180903). | Paper_evidence | WBPaper00002536 |
| | | | | | WBPaper00002749 |
| | | | | | WBPaper00005799 |
| | | | | | WBPaper00006125 |
| | | | | Curator_confirmed | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable calcium ion binding activity and ryanodine-sensitive calcium-release channel activity. Involved in locomotion; positive regulation of programmed cell death; and protein localization to organelle. Located in I band and sarcoplasmic reticulum. Expressed in body wall musculature; intestine; neurons; and non-striated muscle. Used to study congenital myopathy 1A and malignant hyperthermia. Human ortholog(s) of this gene implicated in several diseases, including catecholaminergic polymorphic ventricular tachycardia 1; intracranial vasospasm; and muscle tissue disease (multiple). Is an ortholog of human RYR1 (ryanodine receptor 1); RYR2 (ryanodine receptor 2); and RYR3 (ryanodine receptor 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:3529 | Homo sapiens | Paper_evidence | WBPaper00059411 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 08 Jun 2021 00:00:00 |
| | | DOID:8545 | Homo sapiens | Paper_evidence | WBPaper00059411 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 08 Jun 2021 00:00:00 |
| | Potential_model (12) |
| Modifies_disease | DOID:11723 |
| Modifies_disease_in_annotation | WBDOannot00000746 |
| Models_disease_asserted (14) |
| Molecular_info | Corresponding_CDS (16) |
| | Corresponding_CDS_history | K11C4.5:wp166 |
| | | K11C4.5:wp184 |
| | | K11C4.5a:wp261 |
| | | K11C4.5b:wp236 |
| | | K11C4.5b:wp261 |
| | | K11C4.5c:wp261 |
| | | K11C4.5d:wp261 |
| | Corresponding_transcript (16) |
| | Other_sequence (63) |
| | Associated_feature (24) |
| Experimental_info | RNAi_result (20) |
| | Expr_pattern (12) |
| | Drives_construct | WBCnstr00006689 |
| | | WBCnstr00010174 |
| | | WBCnstr00010354 |
| | | WBCnstr00010749 |
| | | WBCnstr00015983 |
| | | WBCnstr00015984 |
| | | WBCnstr00039937 |
| | | WBCnstr00039938 |
| | Construct_product | WBCnstr00000351 |
| | | WBCnstr00000352 |
| | | WBCnstr00006689 |
| | | WBCnstr00010354 |
| | | WBCnstr00010749 |
| | | WBCnstr00014791 |
| | | WBCnstr00016961 |
| | | WBCnstr00017064 |
| | Antibody (12) |
| | Microarray_results (34) |
| | Expression_cluster | WBPaper00005700:transmembrane_protein |
| | | WBPaper00031040:Cluster_1 |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00033065:isp-1-1(qm150)_upregulated |
| | | WBPaper00035269:cde-1_regulated |
| | | WBPaper00036291:ung-1_regulated |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044316:HgCl2_20uM_downregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045417:128Q-huntingtin_upreglated |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set2 |
| | | WBPaper00047132:glp-1(ts)-25C_upregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050182:lmn-1(L535P)_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:ash-2(RNAi)_regulated_intestine |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055969:electromagnetic-field_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056855:his-72(uge40)_downregulated |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057162:meg-3_meg-4_downregulated_sRNA |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00059895:wounding_downregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061210:huIs179_upregulated |
| | | WBPaper00061340:BWM_anterior |
| | | WBPaper00061340:BWM_far_posterior |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061527:172183_at-176110_at |
| | | WBPaper00061527:myo-3-Y71G12B.11_22540 |
| | | WBPaper00061527:tnt-4-myo-1_2160 |
| | | WBPaper00061651:BDU_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:I3_enriched |
| | | WBPaper00061651:LUA_enriched |
| | | WBPaper00061651:PVD_enriched |
| | | WBPaper00061651:PVR_enriched |
| | | WBPaper00061753:csr-1(tor159)_downregulated_20C |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062293:isp-1(qm150)_upregulated |
| | | WBPaper00062325:etr-1(lq61)_downregulated |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064080:miR-2_miRNA_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064728:cpl-1(W32AY35A)_upregulated |
| | | WBPaper00064735:bet-1B(OE)mys-1(RNAi)_vs_mys-1(RNAi)_downregulated |
| | | WBPaper00064735:mys-1(RNAi)_vs_N2_upregulated |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065623:97 |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:4_0 |
| | | WBPaper00065841:7_0 |
| | | WBPaper00065841:7_1 |
| | | WBPaper00065841:38_2 |
| | | WBPaper00065841:70_1 |
| | | WBPaper00065841:80_0 |
| | | WBPaper00065841:108_0 |
| | | WBPaper00065841:143_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4386_cluster_6_6 |
| | | cgc4489_group_14 |
| | | cgc4489_group_20 |
| | | cgc4489_male_enriched_neuronal_genes |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027111:rrf-2(ok210)_upregulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035560:ahr-1_upregulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00036375:depleted_in_PVD_OLL |
| | | WBPaper00037113:Diazinon_16C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5 |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040823:alg-1(gk214)_downregulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040963:TA200_down |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041002:HQ_3d_2.0mM_Down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00049311:AgNO3_regulated |
| | | WBPaper00049311:sAg-MNP_regulated |
| | | WBPaper00050650:mBmkTX_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_C |
| | Interaction (56) |
| Map_info | Map | V | Position | 0.477486 | Error | 0.002969 |
| | Well_ordered |
| | Positive | Inside_rearr | sDf20 |
| | | Positive_clone | K11C4 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | M04C11 |
| | Negative | Outside_rearr | nDf31 |
| | | Negative_clone | M04C11 |
| | Mapping_data (3) |
| | Landmark_gene |
| Reference (150) |
| Remark | results of mutation site, phenotype, rescue appear in J. Mol. Biol. 267, 849-864. 1997 Sakube, Y., Ando, H. & Kagawa H. |
| Method | Gene |