| WBGene00012759 | SMap | S_parent | Sequence | Y41C4A |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | sup-1 | Paper_evidence | WBPaper00041593 |
| | | | | Person_evidence | WBPerson201 |
| | | Sequence_name | Y41C4A.13 |
| | | Molecular_name | Y41C4A.13 |
| | | | Y41C4A.13.1 |
| | | | CE20253 |
| | | Other_name | CELE_Y41C4A.13 | Accession_evidence | NDB | BX284603 |
| | | Public_name | sup-1 |
| | DB_info | Database | AceView | gene | 3M822 |
| | | | WormQTL | gene | WBGene00012759 |
| | | | WormFlux | gene | WBGene00012759 |
| | | | NDB | locus_tag | CELE_Y41C4A.13 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00012759|UniProtKB=Q9XWU2 |
| | | | | family | PTHR34149 |
| | | | NCBI | gene | 189815 |
| | | | RefSeq | protein | NM_067119.7 |
| | | | SwissProt | UniProtAcc | Q9XWU2 |
| | | | TREEFAM | TREEFAM_ID | TF319571 |
| | | | UniProt_GCRP | UniProtAcc | Q9XWU2 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 2 | 12 Oct 2012 15:09:29 | WBPerson2970 | Event | Acquires_merge | WBGene00006312 |
| | | | | | | Name_change | CGC_name | sup-1 |
| | | Acquires_merge | WBGene00006312 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | sup |
| | Reference_allele | WBVar00143668 |
| | Allele (115) |
| | Legacy_information | e995dm : dominant suppressor of unc-17(e245); does not suppress unc-17(e876); no phenotype alone. ES3 in presence of e245 ME3. NA > 5 (e995xri etc. : all resemble e995). |
| | | See also e995, e996, e1826, e1827, e1909, e1955 |
| | | [C.elegansII] e995dm : dominant allele-specific suppressor of unc-17(e245); does not suppress unc-17(e876); no phenotype alone. ES3 in presence of e245 ME3. OA>5: e996xri, e1827, e1955 etc. (all similar). [CB; RM] |
| | Strain | WBStrain00033410 |
| | | WBStrain00033411 |
| | | WBStrain00033415 |
| | | WBStrain00033416 |
| | | WBStrain00004371 |
| | | WBStrain00004632 |
| | | WBStrain00023506 |
| | | WBStrain00023498 |
| | RNASeq_FPKM (74) |
| | GO_annotation (15) |
| | Ortholog (25) |
| | Paralog | WBGene00007474 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00009915 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00010598 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00011220 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00044477 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | WBGene00194747 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00018348 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00194733 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00022698 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00044756 | Caenorhabditis elegans | From_analysis | Panther |
| | Structured_description | Concise_description | sup-1 encodes a novel, single-pass transmembrane protein; sup-1 was identified as an allele-specific dominant suppressor of unc-17(e245); unc-17 encodes a synaptic vesicle acetylcholine transporter and the e245 missense mutation results in substitution of arginine for glycine in the ninth transmembrane domain and reduced levels of UNC-17 protein; sup-1 is defined by several alleles that all behave similarly as dominant suppressors of unc-17(e245) and have no phenotype on their own; SUP-1 reporter fusion proteins are expressed in cholinergic neurons and body wall muscles, where they localize to the plasma membrane and are found in synaptic regions. | Paper_evidence | WBPaper00004985 |
| | | | | | WBPaper00002665 |
| | | | | | WBPaper00041593 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 04 Dec 2012 00:00:00 |
| | | Automated_description | Located in neuron projection; neuronal cell body membrane; and synapse. Expressed in body wall musculature; neurons; and ventral nerve cord. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | Y41C4A.13 |
| | Corresponding_transcript | Y41C4A.13.1 |
| | Other_sequence (27) |
| | Associated_feature | WBsf717994 |
| | | WBsf994480 |
| | | WBsf994481 |
| | | WBsf1016074 |
| | | WBsf1016075 |
| | | WBsf227597 |
| Experimental_info | RNAi_result | WBRNAi00020471 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00006756 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00036994 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00056355 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr10560 |
| | | Expr1028714 |
| | | Expr1035644 |
| | | Expr1159840 |
| | | Expr2017128 |
| | | Expr2035264 |
| | Drives_construct | WBCnstr00015438 |
| | | WBCnstr00015440 |
| | | WBCnstr00015444 |
| | | WBCnstr00015445 |
| | | WBCnstr00015446 |
| | | WBCnstr00015447 |
| | | WBCnstr00015759 |
| | Construct_product | WBCnstr00015438 |
| | | WBCnstr00015440 |
| | | WBCnstr00015441 |
| | | WBCnstr00015444 |
| | | WBCnstr00015445 |
| | | WBCnstr00015446 |
| | | WBCnstr00015447 |
| | | WBCnstr00015759 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00024970:GABAergic_neuron_specific |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00038061:aldicarb_downregulated |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040560:hpl-2_embryo_upregulated |
| | | WBPaper00044260:1-methylnicotinamide_upregulated |
| | | WBPaper00044260:nicotinc-acid_upregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045314:S.aureus-induced_hlh-30(tm1978) |
| | | WBPaper00045314:S.aureus-induced_N2 |
| | | WBPaper00045316:prg-1_upregulated_L3 |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046496:Rifampicin_upregulated |
| | | WBPaper00046497:B.thuringiensis_upregulated_protein |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set1 |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00047132:glp-1(ts)-25C_upregulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050903:mir-35-41(nDf50)_25C_upregulated |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_downregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053771:up_at_3h-NaCl |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056167:ifo-1(kc2)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057140:pptr-1(tm3103)_downregulated |
| | | WBPaper00057162:meg-3_meg-4_downregulated_sRNA |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:Anterior_arcade_cell |
| | | WBPaper00061340:ant_arc_V |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:hmc_and_homolog |
| | | WBPaper00061340:hyp1_hyp2 |
| | | WBPaper00061340:K_Kprime |
| | | WBPaper00061340:Parent_of_PVP_and_rect_V |
| | | WBPaper00061340:Posterior_arcade_cell |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:URX |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:snt-4_17845-T27C4.1 |
| | | WBPaper00061651:ALA_enriched |
| | | WBPaper00061651:AS_enriched |
| | | WBPaper00061651:AVA_enriched |
| | | WBPaper00061651:AVM_enriched |
| | | WBPaper00061651:DA9_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:FLP_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:PLM_enriched |
| | | WBPaper00061651:PLN_enriched |
| | | WBPaper00061651:PVC_enriched |
| | | WBPaper00061651:PVD_enriched |
| | | WBPaper00061651:PVM_enriched |
| | | WBPaper00061651:PVW_enriched |
| | | WBPaper00061651:RID_enriched |
| | | WBPaper00061651:SAA_enriched |
| | | WBPaper00061651:SAB_enriched |
| | | WBPaper00061651:SIA_enriched |
| | | WBPaper00061651:SIB_enriched |
| | | WBPaper00061651:SMB_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064130:Beta-Amyloid_upregulated_protein |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064505:tamoxifen_downregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065623:46 |
| | | WBPaper00065623:137 |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:28_0 |
| | | WBPaper00065841:29_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066110:Doxorubicin_upregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4386_cluster_3_6 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00036383:ash-2_Day8_regulated |
| | | WBPaper00038060:SUMO-1_downregulated |
| | | WBPaper00038427:lin-54_germline_changed |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00040210:Chlorpyrifos_24C_regulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5 |
| | | WBPaper00040963:TA300_up |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041002:HQ_3d_0.2mM_Up |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotype_environment_interaction |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00042258:DA1877_upregulated_GravidAdult |
| | | WBPaper00042274:tbx-2(bx59)_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | Interaction (16) |
| Map_info | Positive | Positive_clone | Y41C4A | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 77 |
| | | | 89 |
| | | Multi_point | 92 |
| | | | 1660 |
| | | | 2028 |
| | | | 2029 |
| | Interpolated_map_position | III | 12.044 |
| Reference | WBPaper00037329 |
| | WBPaper00039285 |
| | WBPaper00041593 |
| | WBPaper00043425 |
| | WBPaper00058518 |
| | WBPaper00061353 |
| Method | Gene |
