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WormBase Tree Display for Gene: WBGene00006742

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Name Class

WBGene00006742SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_nameunc-2Person_evidenceWBPerson261
Sequence_nameT02C5.5
Molecular_name (45)
Other_nameCELE_T02C5.5Accession_evidenceNDBBX284606
Public_nameunc-2
DB_infoDatabaseAceViewgeneXD330
WormQTLgeneWBGene00006742
WormFluxgeneWBGene00006742
OMIMdisease141500
gene601011
601013
NDBlocus_tagCELE_T02C5.5
PanthergeneCAEEL|WormBase=WBGene00006742|UniProtKB=A0A3B1E663
familyPTHR45628
NCBIgene180570
RefSeqprotein (15)
TrEMBLUniProtAccA0A1N7SYV7
A0A1N7SYU0
A0A1N7SYV5
A0A3B1E663
A0A1N7SYT1
G5EFB0
A0A3B1E695
A0A1N7SYT0
A0A1N7SYU6
A0A1N7SYU4
Q86G45
A0A1N7SYT8
A0A3B1DR32
A0A3B1E4Z9
Q8MPY5
UniProt_GCRPUniProtAccA0A3B1E663
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_info (11)
Disease_infoExperimental_modelDOID:6364Homo sapiensPaper_evidenceWBPaper00006272
Accession_evidenceOMIM141500
Curator_confirmedWBPerson324
Date_last_updated14 Apr 2014 00:00:00
Potential_modelDOID:10024Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1388)
DOID:0080454Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1388)
DOID:0050956Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1388)
DOID:0112205Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1392)
DOID:2377Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1389)
DOID:0111181Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1388)
DOID:0050214Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1389)
DOID:0050990Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1388)
DOID:4724Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1389)
DOID:6364Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1388)
Disease_relevanceMutations in the human calcium channel CACNA1A (Calcium channel, voltage-dependent, P/Q type, alpha-1A subunit) are associated with Episodic ataxia (type 2), which affects the nervous system, resulting in migraines, vision and speech defects, and muscle weakness; mutations in CACNA1A also cause Spinocerebellar ataxia (type 6), a progressive movement disorder; voltage dependent calcium channels mediate calcium entry into cells and are involved in several calcium dependent processes; genetic studies in elegans show that unc-2, the ortholog of CACNA1A, negatively modulates a transforming growth factor (TGF)-beta pathway to affect certain phenotypes like movement, and for the normal accumulation of serotonin levels; further, unc-2 dependent inhibition of the TGF-beta pathway regulates the transcriptional expression of trytophan hydroxylase (tph-1) in serotonergic neurons under stress conditions like starvation and raised temperature; a construct expressing human CACNA1A can substitute for unc-2 function in elegans.Homo sapiensPaper_evidenceWBPaper00006272
Accession_evidenceOMIM601011
Curator_confirmedWBPerson324
Date_last_updated14 Apr 2014 00:00:00
Models_disease_in_annotationWBDOannot00000025
Molecular_infoCorresponding_CDS (15)
Corresponding_CDS_historyT02C5.5b:wp102
T02C5.5d:wp271
T02C5.5e:wp272
Corresponding_transcript (15)
Other_sequence (50)
Associated_feature (42)
Experimental_infoRNAi_result (18)
Expr_pattern (13)
Drives_constructWBCnstr00003100
WBCnstr00003101
WBCnstr00004845
WBCnstr00004847
WBCnstr00038221
Construct_productWBCnstr00005852
WBCnstr00005853
WBCnstr00005854
WBCnstr00020432
WBCnstr00022471
WBCnstr00023025
WBCnstr00023027
Microarray_results (47)
Expression_clusterWBPaper00024970:GABAergic_neuron_specific
WBPaper00032976:dosage_compensated_genes
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037055:DAF-16_binding_DNA
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00040285:H2S_12hr_downregulated
WBPaper00040285:H2S_24hr_downregulated
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00045316:prg-1_upregulated_L2
WBPaper00045316:prg-1_upregulated_L4
WBPaper00045390:ubc-9(RNAi)_downregulated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Oogenic
WBPaper00046121:ecdoderm_unique
WBPaper00046161:Q40-aggregate-protein_Day7_Sarcosyl-insoluble
WBPaper00046509:htz-1(ok3099)_downregulated
WBPaper00046805:csr-1(RNAi)_downregulated_Set1
WBPaper00046805:csr-1(RNAi)_downregulated_Set2
WBPaper00048423:LP133_LF21_upregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049626:UNC-75_target
WBPaper00050344:AFD-neuron_enriched
WBPaper00050344:PLM-neuron_enriched
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051404:alg-1(gk214)_upregulated
WBPaper00051404:alg-2(ok304)_upregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053295:lin-22(ot267)_upregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055565:AVK_enriched
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056139:gut-microbiota_downregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
WBPaper00056275:P.aeruginosa_upregulated
WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
WBPaper00056284:ints-5(RNAi)_upregulated
WBPaper00056284:ints-11(RNAi)_downregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056619:CEPsh_enriched
WBPaper00056809:smn-1(ok355)_upregulated
WBPaper00056826:hmc_biased
WBPaper00057288:Cold_upregulated_transcript
WBPaper00057288:iff-1(RNAi)_upregulated_transcript
WBPaper00057347:nhr-14(tm1473)_downreglated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058725:sftb-1(cer39)_downregulated
WBPaper00058948:PA14_downregulated
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00058969:RIS_enriched
WBPaper00059027:neuron-synapses_depleted
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059763:neuron_expressed
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061007:HB101_upregulated
WBPaper00061081:E.faecalis_upregulated_N2
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:ADF_AWB
WBPaper00061340:ALM_PLM
WBPaper00061340:ASE_parent
WBPaper00061340:AVA
WBPaper00061340:DA_DB
WBPaper00061340:I5
WBPaper00061340:IL1_parent
WBPaper00061340:mu_int_mu_anal
WBPaper00061340:Neuroblast_ADE_ADA
WBPaper00061340:Neuroblast_ASJ_AUA
WBPaper00061340:OLL
WBPaper00061340:OLL_parent
WBPaper00061340:RIA
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061527:sol-1-jnk-1_18695
WBPaper00061527:sre-33-ZK1025.1_8337
WBPaper00061527:tub-2_4713-daf-2_5288
WBPaper00061651:DA9_enriched
WBPaper00061651:PVM_enriched
WBPaper00061651:RIA_enriched
WBPaper00061753:csr-1(tor159)_upregulated_25C
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062056:lin-15B(n744)_upregulated
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mes-4(bn73)_upregulated_EGCs
WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
WBPaper00064721:fasn-1(g14)_downregulated_starved
WBPaper00064735:mys-1(RNAi)_vs_N2_upregulated
WBPaper00064871:hypoxia_downregulated_F2
WBPaper00064939:vit-5(RNAi)_upregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065158:AFD_enriched
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065841:39_1
WBPaper00065841:66_0
WBPaper00065841:70_1
WBPaper00065841:83_0
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065995:M.humicola-extract_downregulated_old-1(ok1273)
cgc4386_cluster_6_5
cgc4489_group_20
WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Enriched_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00027111:rde-3(ne298)_upregulated
WBPaper00027111:rde-3(r459)_upregulated
WBPaper00029437:dcr-1_upregulated
WBPaper00030839:Embryo_A_Class
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00030839:Larval_A_Class
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00031832:slr-2_regulated
WBPaper00034661:AgNPs_downregulated
WBPaper00035227:heat_shock_regulated
WBPaper00035588:alg-1(-)_upregulated
WBPaper00036123:Atrazine_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00041906:I-3690_vs_OP50_10d
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-exposed_3h
WBPaper00041939:control_vs_UVC-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042548:miRISC_enriched
WBPaper00045673:colistin_upregulated
WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
WBPaper00047070:N2_starvation_upregulated
WBPaper00047070:xpa-1_UV_downregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc6390]:Cluster_A
InteractionWBInteraction000000410
WBInteraction000002254
WBInteraction000002255
WBInteraction000002258
WBInteraction000002260
WBInteraction000002261
WBInteraction000002262
WBInteraction000002263
WBInteraction000008869
WBInteraction000008870
WBInteraction000008871
WBInteraction000008872
WBInteraction000008904
WBInteraction000009060
WBInteraction000009061
WBInteraction000009494
WBInteraction000009928
WBInteraction000028632
WBInteraction000028727
WBInteraction000029224
WBInteraction000029330
WBInteraction000029651
WBInteraction000030267
WBInteraction000033455
WBInteraction000034453
WBInteraction000035594
WBInteraction000036200
WBInteraction000038740
WBInteraction000038741
WBInteraction000039739
WBInteraction000040058
WBInteraction000040156
WBInteraction000041919
WBInteraction000042508
WBInteraction000043987
WBInteraction000044198
WBInteraction000045155
WBInteraction000045217
WBInteraction000045899
WBInteraction000045936
WBInteraction000046901
WBInteraction000047252
WBInteraction000047883
WBInteraction000048022
WBInteraction000049336
WBInteraction000050013
WBInteraction000050014
WBInteraction000052099
WBInteraction000052101
WBInteraction000052793
WBInteraction000115442
WBInteraction000124620
WBInteraction000124967
WBInteraction000125937
WBInteraction000125938
WBInteraction000126011
WBInteraction000126296
WBInteraction000126297
WBInteraction000126298
WBInteraction000126330
WBInteraction000126463
WBInteraction000126596
WBInteraction000126802
WBInteraction000127094
WBInteraction000127126
WBInteraction000127275
WBInteraction000127276
WBInteraction000127411
WBInteraction000127521
WBInteraction000132991
WBInteraction000133350
WBInteraction000133351
WBInteraction000133364
WBInteraction000133690
WBInteraction000133844
WBInteraction000133845
WBInteraction000134943
WBInteraction000134944
WBInteraction000135319
WBInteraction000139427
WBInteraction000157026
WBInteraction000158621
WBInteraction000160349
WBInteraction000163174
WBInteraction000165606
WBInteraction000165626
WBInteraction000165633
WBInteraction000165653
WBInteraction000165660
WBInteraction000166372
WBInteraction000166396
WBInteraction000166940
WBInteraction000167157
WBInteraction000173896
WBInteraction000173991
WBInteraction000204106
WBInteraction000204107
WBInteraction000209621
WBInteraction000212022
WBInteraction000237300
WBInteraction000240467
WBInteraction000251953
WBInteraction000252758
WBInteraction000252759
WBInteraction000252760
WBInteraction000252761
WBInteraction000252762
WBInteraction000297575
WBInteraction000306605
WBInteraction000338456
WBInteraction000338457
WBInteraction000338458
WBInteraction000338459
WBInteraction000339724
WBInteraction000362003
WBInteraction000375769
WBInteraction000377216
WBInteraction000377726
WBInteraction000380286
WBInteraction000381013
WBInteraction000392443
WBInteraction000393515
WBInteraction000398581
WBInteraction000414111
WBInteraction000414112
WBInteraction000415230
WBInteraction000423514
WBInteraction000439794
WBInteraction000447618
WBInteraction000447619
WBInteraction000464729
WBInteraction000468635
WBInteraction000472748
WBInteraction000472749
WBInteraction000472750
WBInteraction000501477
WBInteraction000501479
WBInteraction000502185
WBInteraction000519343
Anatomy_functionWBbtf0544
WBbtf0547
WBbtf0550
Map_infoMapXPosition-13.7946Error0.063386
Well_ordered
PositivePositive_cloneT02C5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point145
153
154
155
156
157
3151
4456
4457
7099
Multi_point (28)
Pos_neg_data (23)
Landmark_gene
Reference (201)
MethodGene