WormBase Tree Display for Gene: WBGene00004746

WBGene00004746 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: sdc-2 Person_evidence: WBPerson421
      Sequence_name: C35C5.1
      Molecular_name: C35C5.1
        C35C5.1.1
        CE18542
      Other_name: CELE_C35C5.1 Accession_evidence: NDB BX284606
      Public_name: sdc-2
    DB_info: Database: AceView gene XM151
        WormQTL gene WBGene00004746
        WormFlux gene WBGene00004746
        NDB locus_tag CELE_C35C5.1
        Panther gene CAEEL|WormBase=WBGene00004746|UniProtKB=G5EBL3
          family PTHR13270
        NCBI gene 181341
        RefSeq protein NM_077523.7
        SwissProt UniProtAcc G5EBL3
        TREEFAM TREEFAM_ID TF350609
        UniProt_GCRP UniProtAcc G5EBL3
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sdc
    Allele (134)
    Legacy_information: See also y15
      [C.elegansII] y15 : XX animals inviable and masculinized, XO animals WT. No maternal rescue. ES3 (XX); ME3.OA>20: y46, y74, y55 (weaker, Egl or Tra phenotypes). ???Cloned: 9.2 kb transcript, encodes predicted 2962 protein (344 kD), highly charged. [Nusbaum and Meyer 1989; TY]
    Strain: WBStrain00035098
      WBStrain00035100
      WBStrain00035166
      WBStrain00035105
    RNASeq_FPKM (74)
    GO_annotation: 00009802
      00009803
      00009804
      00009805
      00009806
      00009807
      00009808
    Ortholog (33)
    Paralog: WBGene00018316 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: The sdc-2 gene encodes a protein that represses transcription of X chromosomes to achieve dosage compensation, and that also represses the male sex-determination gene her-1 to elicit hermaphrodite differentiation. Paper_evidence: WBPaper00005215
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Involved in dosage compensation by hypoactivation of X chromosome and negative regulation of transcription by RNA polymerase II. Located in nuclear chromosome. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C35C5.1
    Corresponding_transcript: C35C5.1.1
    Other_sequence: AF111934
    Associated_feature (9)
    Gene_product_binds: WBsf019092
      WBsf019093
    Transcription_factor: WBTranscriptionFactor000093
      WBTranscriptionFactor000689
  Experimental_info: RNAi_result (35)
    Expr_pattern: Expr10429
      Expr11875
      Expr1028636
      Expr1032344
      Expr1145975
      Expr2015659
      Expr2033892
    Drives_construct: WBCnstr00006791
      WBCnstr00015322
      WBCnstr00035415
    Construct_product: WBCnstr00005103
      WBCnstr00005104
      WBCnstr00006790
      WBCnstr00006791
      WBCnstr00035415
    Antibody: WBAntibody00000228
      WBAntibody00000496
      WBAntibody00000497
      WBAntibody00001184
      WBAntibody00002039
      WBAntibody00002042
      WBAntibody00002043
    Microarray_results (21)
    Expression_cluster: WBPaper00028867:PAL-1_induced_TF
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:all-neurons_embryo_enriched
      WBPaper00037950:AVA-neuron_embryo_enriched
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_embryo_enriched
      WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044736:flat_dev_expression
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045521:Oogenic
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00046805:csr-1(RNAi)_downregulated_Set2
      WBPaper00048690:male-Z1-Z4_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_enriched
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051305:vit-2(ac3)_upregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:mes-4(RNAi)_downregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055386:daf-2(e1370)_downregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched
      WBPaper00056139:gut-microbiota_downregulated
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056855:his-72(uge40)_downregulated
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058711:paraquat_upregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061527:pek-1_22220-pek-1_33
      WBPaper00061527:utx-1_2886-swan-1_2192
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064107:lin-52(3A)_vs_lin-52(WT)_upregulated
      WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065158:AFD_enriched
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Cisplatin_downregulated_diploid
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025032:cluster_9
      WBPaper00025032:cluster_17
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00032062:age_regulated_genes
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00036286:Pattern_D
      WBPaper00040823:alg-1(gk214)_downregulated
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040876:mir-35_upregulated
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_4
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(122_min)
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SET
      [cgc5767]:expression_class_SE_pi(53_min)
      [cgc6390]:mixed_oogenesis-somatic
    Interaction: WBInteraction000000038
      WBInteraction000000039
      WBInteraction000000040
      WBInteraction000000085
      WBInteraction000000086
      WBInteraction000000144
      WBInteraction000000145
      WBInteraction000000258
      WBInteraction000000459
      WBInteraction000000495
      WBInteraction000000895
      WBInteraction000001656
      WBInteraction000001657
      WBInteraction000001663
      WBInteraction000002892
      WBInteraction000003074
      WBInteraction000003110
      WBInteraction000003235
      WBInteraction000003237
      WBInteraction000003243
      WBInteraction000003418
      WBInteraction000003622
      WBInteraction000005253
      WBInteraction000005254
      WBInteraction000005256
      WBInteraction000006088
      WBInteraction000006157
      WBInteraction000006173
      WBInteraction000006257
      WBInteraction000006276
      WBInteraction000006333
      WBInteraction000006374
      WBInteraction000007795
      WBInteraction000009666
      WBInteraction000009779
      WBInteraction000030361
      WBInteraction000030844
      WBInteraction000031689
      WBInteraction000031692
      WBInteraction000052061
      WBInteraction000052062
      WBInteraction000052070
      WBInteraction000052072
      WBInteraction000052073
      WBInteraction000052075
      WBInteraction000052078
      WBInteraction000052459
      WBInteraction000052916
      WBInteraction000126263
      WBInteraction000127073
      WBInteraction000133743
      WBInteraction000166211
      WBInteraction000166212
      WBInteraction000166466
      WBInteraction000172102
      WBInteraction000179640
      WBInteraction000185230
      WBInteraction000191525
      WBInteraction000311373
      WBInteraction000313077
      WBInteraction000333765
      WBInteraction000345919
      WBInteraction000417210
      WBInteraction000501494
      WBInteraction000504064
      WBInteraction000519974
      WBInteraction000519984
      WBInteraction000519988
      WBInteraction000540686
      WBInteraction000540707
      WBInteraction000541629
      WBInteraction000542611
      WBInteraction000542642
      WBInteraction000550411
      WBInteraction000550412
      WBInteraction000554822
      WBInteraction000554823
    WBProcess: WBbiopr:00000056
  Map_info: Map: X Position: 4.34757 Error: 0.06798
    Well_ordered
    Positive: Inside_rearr: yDp7
      Positive_clone: C03B2
        C35C5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 1438
        1439
        1440
        1774
        2062
        2293
        3319
        3642
        3643
        3687
      Pos_neg_data (11)
    Landmark_gene
  Reference (135)
  Method: Gene