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WormBase Tree Display for Gene: WBGene00000226

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Name Class

WBGene00000226EvidenceCGC_data_submission
SMapS_parentSequenceT06E4
IdentityVersion1
NameCGC_nameatl-1Person_evidenceWBPerson1551
Sequence_nameT06E4.3
Molecular_nameT06E4.3a
T06E4.3a.1
CE25103
T06E4.3c
CE45629
T06E4.3a.2
T06E4.3c.1
Other_nameCe-atl1Accession_evidenceEMBLAB018598
CELE_T06E4.3Accession_evidenceNDBBX284605
Public_nameatl-1
DB_infoDatabase (15)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classatl
Allele (123)
StrainWBStrain00036017
WBStrain00006438
RNASeq_FPKM (74)
GO_annotation (25)
Contained_in_operonCEOP5585
Ortholog (43)
ParalogWBGene00004879Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000227Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002583Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00007028Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionThe atl-1 gene encodes a large, 2514-residue protein of the ATM family, homologous to human AT (OMIM:208900, mutated in ataxia telangiectasia); the C-terminal sequence of ATL-1 contains a PI-3 kinase-like domain; ATL-1 is required for survival through early embryogenesis and normal chromosomal segregation; atl-1 is expressed in both the mitotic and meiotic cells of adult gonads.Paper_evidenceWBPaper00004326
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable 1-phosphatidylinositol-3-kinase activity and protein serine/threonine kinase activity. Involved in DNA damage checkpoint signaling; embryo development; and meiotic chromosome segregation. Located in nucleus. Expressed in gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Seckel syndrome 1; gastrointestinal system cancer (multiple); and pancreatic cancer. Is an ortholog of human ATR (ATR serine/threonine kinase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:10652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:882)
DOID:9261Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:882)
DOID:0070007Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:882)
DOID:1324Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:882)
DOID:1793Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:882)
DOID:219Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:882)
DOID:0080202Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:882)
Molecular_infoCorresponding_CDS (2)
Corresponding_CDS_historyT06E4.3:wp52
T06E4.3b:wp270
Corresponding_transcriptT06E4.3a.1
T06E4.3a.2
T06E4.3c.1
Other_sequenceAB018598
SRC07073_1
FC813984.1
FG976670.1
Associated_featureWBsf652930
WBsf669247
WBsf234255
Experimental_infoRNAi_result (23)
Expr_patternExpr1119
Expr1120
Expr4273
Expr11800
Expr1019215
Expr1030143
Expr1156260
Expr2009505
Expr2027742
Drives_constructWBCnstr00037648
Construct_productWBCnstr00037648
AntibodyWBAntibody00001035
WBAntibody00001157
Microarray_results (29)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00033065:isp-1-1(qm150)_upregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_embryo_enriched
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:AVA-neuron_embryo_enriched
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:bodywall-muscle_larva_enriched
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00042477:prp-8(RNAi)_upregulated_RNAseq
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045417:128Q-huntingtin_upreglated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_downregulated
WBPaper00048988:neuron_expressed
WBPaper00049290:rsks-1(sv31)_upregulated
WBPaper00049626:UNC-75_target
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_downregulated_N2
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050522:mafr-1(tm6082)_downregulated
WBPaper00050743:elli-1(sam-3)_upregulated
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:body-muscle_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:germline_enriched
WBPaper00051265:F4_morc-1(tm6048)_upregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053289:DREAM-target
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055482:pmt-2(RNAi)_downregulated
WBPaper00055648:germline_expressed
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_downregulated_N2
WBPaper00056165:MINA-1_interacting_mRNA
WBPaper00057288:Cold_upregulated_transcript
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00058691:set-2(bn129)_downregulated
WBPaper00058725:sftb-1(cer6)_upregulated
WBPaper00058886:anp-1(ok608)_downregulated
WBPaper00059664:srbc-48(ac23)_downregulated
WBPaper00060084:cco-1(RNAi)_upregulated_N2
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060445:ikb-1(nr2027)_upregulated_L4
WBPaper00060445:nfki-1(cer1)_upregulated_L4
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060871:M.humicola-infection_48h_regulated
WBPaper00061274:hypergravity_10xg_upregulated
WBPaper00061340:CAN
WBPaper00061341:28C_24h_downregulated
WBPaper00061390:daf-22(ok693)_ascarosides_upregulated
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
WBPaper00061527:atl-1_322-emb-30_324
WBPaper00061753:csr-1(tor159)_downregulated_20C
WBPaper00062056:lin-15B(n744)_upregulated
WBPaper00062103:neuron_enriched
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064716:paraquat_upregulated
WBPaper00064939:vit-5(RNAi)_upregulated
WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065945:epidermis-rpoa-2(-)_upregulated_transcript
WBPaper00065945:global-rpoa-2(-)_upregulated_transcript
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:tetraploid_vs_diploid_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4489_group_9
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Enriched_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00030839:Embryo_A_Class
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00035905:FBF-1_Associated
WBPaper00040823:alg-1(gk214)_downregulated
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00041002:HF_3d_2.0mM_Down
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00047070:N2_UV_upregulated
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00053688:E.faecium_upregulated
[cgc5767]:cluster_46
[cgc5767]:expression_class_E
[cgc5767]:expression_class_ET
[cgc5767]:expression_class_ET_max(143_min)
[cgc5767]:expression_class_E_pi(66_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MDE
[cgc5767]:expression_class_MDET
[cgc5767]:expression_class_MD_pd(41_min)
[cgc5767]:expression_class_MD_pd(53_min)
[cgc5767]:expression_class_ME
[cgc5767]:expression_class_MET
[cgc6390]:intrinsic
Interaction (114)
Map_infoMapVPosition2.06022Error0.000681
PositivePositive_cloneT06E4Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (70)
RemarkSequence connection from [Boulton S, Vidal M]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene