WormBase Tree Display for Gene: WBGene00000478

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WBGene00000478	SMap	S_parent	Sequence	F27E11
	Identity	Version	1
		Name	CGC_name	cfz-2	Person_evidence	WBPerson194
			Sequence_name	F27E11.3
			Molecular_name	F27E11.3
				F27E11.3.1
				CE39149
			Other_name	CELE_F27E11.3	Accession_evidence	NDB	BX284605
			Public_name	cfz-2
		DB_info	Database	AceView	gene	5D920
				WormQTL	gene	WBGene00000478
				SignaLink	protein	WBGene00000478
				WormFlux	gene	WBGene00000478
				NDB	locus_tag	CELE_F27E11.3
				Panther	gene	CAEEL\|EnsemblGenome=WBGene00000478\|UniProtKB=G5ECQ2
					family	PTHR11309
				NCBI	gene	178768
				RefSeq	protein	NM_071564.8
				SwissProt	UniProtAcc	G5ECQ2
				UniProt_GCRP	UniProtAcc	G5ECQ2
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:21	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	cfz
		Allele (196)
		Strain	WBStrain00031864
			WBStrain00008500
			WBStrain00008502
			WBStrain00008506
		RNASeq_FPKM (74)
		GO_annotation (29)
		Ortholog (61)
		Paralog	WBGene00003006	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
			WBGene00003238	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
			WBGene00003397	Caenorhabditis elegans	From_analysis	TreeFam
						WormBase-Compara
			WBGene00022242	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
		Structured_description	Concise_description	cfz-2 encodes one of four C. elegans Frizzled homologs, integral membrane proteins that contain an external cysteine-rich domain (CRD) and seven transmembrane domains and that function in a wide variety of species as receptors for Wnt glycoprotein signaling molecules; CFZ-2 activity is required for cell migration and for vulval development.	Paper_evidence	WBPaper00026706
						WBPaper00028436
						WBPaper00032017
						WBPaper00035405
						WBPaper00037046
					Curator_confirmed	WBPerson48
						WBPerson1843
					Date_last_updated	28 Oct 2010 00:00:00
			Automated_description	Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Involved in neuroblast migration; neuron migration; and positive regulation of motor neuron migration. Predicted to be located in plasma membrane. Expressed in intestine; nervous system; and pharynx. Is an ortholog of human FZD5 (frizzled class receptor 5).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	F27E11.3
		Corresponding_CDS_history	F27E11.3a:wp149
			F27E11.3a:wp246
			F27E11.3b:wp149
			F27E11.3b:wp246
		Corresponding_transcript	F27E11.3.1
		Other_sequence (12)
		Associated_feature (22)
	Experimental_info	RNAi_result	WBRNAi00061144	Inferred_automatically	RNAi_primary
			WBRNAi00045754	Inferred_automatically	RNAi_primary
			WBRNAi00091577	Inferred_automatically	RNAi_primary
			WBRNAi00045753	Inferred_automatically	RNAi_primary
			WBRNAi00028248	Inferred_automatically	RNAi_primary
			WBRNAi00014004	Inferred_automatically	RNAi_primary
			WBRNAi00101351	Inferred_automatically	RNAi_primary
			WBRNAi00098912	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr3645
			Expr4446
			Expr11482
			Expr13819
			Expr1026605
			Expr1030280
			Expr1149663
			Expr2009941
			Expr2028181
		Drives_construct	WBCnstr00011569
			WBCnstr00012010
			WBCnstr00040137
		Construct_product	WBCnstr00008352
			WBCnstr00019046
		Microarray_results (27)
		Expression_cluster	WBPaper00036375:enriched_in_PVD_OLL
			WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
			WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
			WBPaper00037950:all-neurons_L2-larva_expressed
			WBPaper00037950:BAG-neuron_blastula-embryo_expressed
			WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
			WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
			WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
			WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
			WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
			WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
			WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
			WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
			WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
			WBPaper00040209:B.thuringiensis_upregulated_MY15
			WBPaper00044260:1-methylnicotinamide_downregulated
			WBPaper00044260:nicotic-acid_downregulated
			WBPaper00044316:CH3HgCl_7.5uM_downregulated
			WBPaper00044426:rotenone_5day_downregulated
			WBPaper00044736:flat_dev_expression
			WBPaper00045390:ubc-9(RNAi)_downregulated
			WBPaper00045729:gld-2(RNAi)_downregulated
			WBPaper00045974:NSM_enriched_totalRNA_RNAseq
			WBPaper00045974:NSM_enriched_totalRNA_tiling
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
			WBPaper00048690:gonad-hermaphrodite-biased
			WBPaper00048923:Aging_regulated
			WBPaper00048988:neuron_enriched
			WBPaper00048988:neuron_expressed
			WBPaper00049098:heat-induced_hrde-1(tm1200)
			WBPaper00049498:npr-1(ur89)_regulated_4
			WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
			WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
			WBPaper00049954:BPS_upregulated
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050726:OsmoticStress_regulated_Food
			WBPaper00050726:OsmoticStress_regulated_NoFood
			WBPaper00050726:starvation_regulated_LowSalt
			WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
			WBPaper00050990:NMDA-neuron_enriched
			WBPaper00050990:NMDA-neuron_expressed
			WBPaper00051352:Long-Term-Association-Memory_upregulated
			WBPaper00051404:alg-1(gk214)_upregulated
			WBPaper00051558:aging_regulated
			WBPaper00053184:sma-2(rax5)_upregulated
			WBPaper00053184:sma-4(rax3)_upregulated
			WBPaper00053321:PGCs_depleted_NuGen
			WBPaper00053814:15C_downregulated_OP50
			WBPaper00054493:hpl-2(tm1489)_upregulated
			WBPaper00054758:alg-1(gk204)_upregulated
			WBPaper00055354:Allantoin_upregulated
			WBPaper00055354:eat-2(ad1116)_upregulated
			WBPaper00055354:Psora-Allantoin_upregulated
			WBPaper00055354:Rapamycin-Metformin_upregulated
			WBPaper00055354:Rifampicin-Allantoin_upregulated
			WBPaper00055354:Rifampicin_upregulated
			WBPaper00055386:daf-2(e1370)_downregulated
			WBPaper00055386:eat-2(ad465)_downregulated
			WBPaper00055482:Tunicamycin_upregulated
			WBPaper00055626:pry-1(mu38)_downregulated
			WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
			WBPaper00055971:nhl-2(ok818)_20C_upregulated
			WBPaper00055971:nhl-2(ok818)_25C_upregulated
			WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
			WBPaper00056161:hermaphrodite_enriched_siRNA
			WBPaper00056167:Cry5B_upregulated
			WBPaper00056284:ints-1(RNAi)_downregulated
			WBPaper00056443:sek-1(km4)_upregulated
			WBPaper00056446:hsb-1(cg116)_upregulated
			WBPaper00056471:S.aureus-4h_downregulated_N2
			WBPaper00056586:kri-1(ok1251);mpk-2(ok219)_downregulated
			WBPaper00056826:hmc_biased
			WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
			WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
			WBPaper00057288:iff-1(RNAi)_upregulated_transcript
			WBPaper00058598:sin-3(tm1276)_downregulated
			WBPaper00058711:paraquat_upregulated
			WBPaper00058711:wdr-5(ok1417)_upregulated
			WBPaper00058958:100mGy-irradiation-72h_upregulated
			WBPaper00058969:RIS_enriched
			WBPaper00059224:tph-1(mg280)_upregulated
			WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
			WBPaper00059440:LAG-1_interacting_germline
			WBPaper00059471:EGL-43_interacting
			WBPaper00059477:hlh-2(RNAi)_regulated
			WBPaper00059664:srbc-48(ac23)_upregulated
			WBPaper00060014:set-2(tm1630)_downregulated
			WBPaper00060661:sensory-neuron_enriched
			WBPaper00060811:L1_vs_adult_upregulated_neural
			WBPaper00061203:sin-3(tm1276)_upregulated
			WBPaper00061203:spr-1(ok2144)_upregulated
			WBPaper00061340:ABarpaaa_lineage
			WBPaper00061340:ADL_parent
			WBPaper00061340:AIM
			WBPaper00061340:AIN_parent
			WBPaper00061340:AVL
			WBPaper00061340:I1_parent
			WBPaper00061340:IL1
			WBPaper00061340:Neuroblast_AWC_SAAVx
			WBPaper00061340:Neuroblast_BAG_SMDVx
			WBPaper00061340:Parent_of_hyp3_ILsoDx
			WBPaper00061340:RIA
			WBPaper00061340:RIB
			WBPaper00061340:RMD
			WBPaper00061340:RME
			WBPaper00061340:RMED
			WBPaper00061340:RME_LR_parent
			WBPaper00061340:SIA
			WBPaper00061340:SIB
			WBPaper00061340:SMB
			WBPaper00061340:SMD
			WBPaper00061341:28C_24h_upregulated
			WBPaper00061341:28C_48h_upregulated
			WBPaper00061424:Diet_MYb120_downregulated
			WBPaper00061424:Diet_MYb131_upregulated
			WBPaper00061479:hda-1(ne4752)_upregulated
			WBPaper00061527:cfz-2_18944-cfz-2_2268
			WBPaper00061651:M3_enriched
			WBPaper00061995:mter-4(syb3662syb3403)_downregulated
			WBPaper00062103:neuron_enriched
			WBPaper00062184:PA14_downregulated
			WBPaper00062193:daf-16(RNAi)_downregulated
			WBPaper00062446:nhr-8(hd117)_upregulated
			WBPaper00062456:doxycycline_downregulated_CB4856_transcript
			WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
			WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
			WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
			WBPaper00064306:Agaro-oligosaccharides_upregulated
			WBPaper00064716:paraquat_upregulated
			WBPaper00064769:him-17(me24)_downregulated
			WBPaper00064871:hypoxia_downregulated_F3
			WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
			WBPaper00065096:Day10_vs_Day1_upregulated
			WBPaper00065096:npr-8(ok1439)_downregulated_Day1_25C
			WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
			WBPaper00065749:endu-2(tm4977)_upregulated
			WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
			WBPaper00065749:Heat-Shock_downregulated_N2
			WBPaper00065835:Day11_vs_Day1_upregulated
			WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day11
			WBPaper00065841:55_0
			WBPaper00065841:94_0
			WBPaper00065841:115_0
			WBPaper00065841:118_0
			WBPaper00065841:124_0
			WBPaper00065993:glp-1(e2141)_downregulated
			WBPaper00066005:RAGA-1_degradation_somatic_upregulated
			WBPaper00066093:E.coli-purE_downregulated
			WBPaper00066110:Cisplatin_downregulated_diploid
			WBPaper00066110:Doxorubicin_downregulated_diploid
			WBPaper00066232:ash-2(RNAi)_upregulated_WT
			WBPaper00066232:hsf-1(RNAi)_downregulated_ash-2
			cgc4386_cluster_6_2
			cgc4489_group_12
			WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00026929:Resveratrol_regulated_daf-16
			WBPaper00027111:rrf-2(ok210)_upregulated
			WBPaper00029437:dcr-1_upregulated
			WBPaper00030839:Larval_Pan_Neuronal
			WBPaper00031003:24hr_muscle_depleted
			WBPaper00031003:total_muscle_depleted
			WBPaper00031252:AIN-1_IP_enriched
			WBPaper00031252:AIN-2_IP_enriched
			WBPaper00031532:Larva_Pan_Neuronal_Enriched
			WBPaper00035084:embryo_enriched_AIN-2_IP
			WBPaper00035084:L2_enriched_AIN-2_IP
			WBPaper00035084:L3_enriched_AIN-2_IP
			WBPaper00035084:L4_enriched_AIN-2_IP
			WBPaper00035560:ahr-1_upregulated
			WBPaper00035588:alg-1(-)_upregulated
			WBPaper00036383:ash-2_Day8_regulated
			WBPaper00040858:eQTL_age_regulated_aging
			WBPaper00040858:eQTL_regulated_aging
			WBPaper00040858:eQTL_regulated_old
			WBPaper00040963:Q100_down
			WBPaper00040963:Q200_down
			WBPaper00040985:AIN-2_asynchronous_muscle
			WBPaper00041002:HQ_3d_0.2mM_Down
			WBPaper00041174:environmental
			WBPaper00041174:genotypic
			WBPaper00041174:genotypic_and_environmental
			WBPaper00041906:I-3690_vs_OP50_3d
			WBPaper00041906:I-4317_vs_OP50_10d
			WBPaper00041939:control_vs_EtBr-exposed_48h
			WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
			WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
			WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
			WBPaper00041960:N2_fasting_upregulated_anytime
			WBPaper00042548:miRISC_enriched
			WBPaper00046639:tyrosol_upregulated
			WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
			WBPaper00053236:Starvation_regulated_GR1307
			WBPaper00057098:SiO2-nanoparticles_upregulated
			[cgc5767]:cluster_26
			[cgc5767]:expression_class_E
			[cgc5767]:expression_class_E_pi(41_min)
			[cgc5767]:expression_class_E_pi(53_min)
			[cgc5767]:expression_class_SE
			[cgc5767]:expression_class_SE_pi(41_min)
			[cgc5767]:expression_class_SE_pi(53_min)
			[cgc6390]:mixed_oogenesis-somatic
		Interaction (46)
		Anatomy_function	WBbtf0068
			WBbtf0811
		WBProcess	WBbiopr:00000023
			WBbiopr:00000073
	Map_info	Map	V	Position	-11.6718	Error	0.034406
		Positive	Positive_clone	F27E11	Inferred_automatically	From CDS info
						From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	4881
				4924
		Pseudo_map_position
	Reference (38)
	Remark	Sequence connection from [Endres JB, Cordes S, Hawkins N, Garriga G], [020802 krb]
		Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene