| WBGene00001005 | SMap | S_parent | Sequence | T26A5 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | dlc-1 | Person_evidence | WBPerson75 |
| | | Sequence_name | T26A5.9 |
| | | Molecular_name | T26A5.9 |
| | | | T26A5.9.1 |
| | | | CE00788 |
| | | Other_name | CELE_T26A5.9 | Accession_evidence | NDB | BX284603 |
| | | Public_name | dlc-1 |
| | DB_info | Database | AceView | gene | 3H554 |
| | | | WormQTL | gene | WBGene00001005 |
| | | | WormFlux | gene | WBGene00001005 |
| | | | NDB | locus_tag | CELE_T26A5.9 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00001005|UniProtKB=Q22799 |
| | | | | family | PTHR11886 |
| | | | NCBI | gene | 175922 |
| | | | RefSeq | protein | NM_001392125.1 |
| | | | SwissProt | UniProtAcc | Q22799 |
| | | | TREEFAM | TREEFAM_ID | TF300264 |
| | | | UniProt_GCRP | UniProtAcc | Q22799 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | dlc |
| | Allele | WBVar01499890 |
| | | WBVar01499891 |
| | | WBVar01500260 |
| | | WBVar00251926 |
| | | WBVar00833776 |
| | | WBVar00833777 |
| | | WBVar00833778 |
| | | WBVar00833779 |
| | | WBVar00833780 |
| | | WBVar00399891 |
| | Strain | WBStrain00001410 |
| | | WBStrain00002397 |
| | RNASeq_FPKM (74) |
| | GO_annotation (25) |
| | Contained_in_operon | CEOP3840 |
| | Ortholog (37) |
| | Paralog | WBGene00010888 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00043067 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00012424 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00012425 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | dlc-1 encodes a dynein light chain 1, required for viability, that inhibits DHC-1 in vivo; DLC-1 is 92-95% identical to its orthologs human DYNLL1 (OMIM:601562) and DYNLL2 (OMIM:608942); DLC-1 is paralogous to DLC-2/-6; DLC-1 is expressed in adult body wall muscle, and in larval and adult pharynx, posterior intestine, and nervous system (e.g., ventral nerve cord, head neurons, and tail neurons); dlc-1 is probably transcriptionally activated by DAF-19; DLC-1 is required for normal embryonic and larval viability, embryonic pronuclear migration, growth speed, fertility, brood size, body shape, and cuticular integrity; anterograde movements of DLC-1 in neurons are regulated by PTL-1/Tau. | Paper_evidence | WBPaper00004403 |
| | | | | | WBPaper00005654 |
| | | | | | WBPaper00006525 |
| | | | | | WBPaper00025051 |
| | | | | | WBPaper00029395 |
| | | | | | WBPaper00030897 |
| | | | | | WBPaper00038442 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 09 Aug 2011 00:00:00 |
| | | Automated_description | Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in several processes, including apoptotic process; cell division; and meiotic cell cycle. Predicted to be located in cytoplasm; microtubule; and nuclear envelope. Predicted to be part of cytoplasmic dynein complex. Expressed in several structures, including germ cell; germ line; rectal valve cell; somatic cell; and ventral nerve cord. Is an ortholog of human DYNLL2 (dynein light chain LC8-type 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | T26A5.9 |
| | Corresponding_transcript | T26A5.9.1 |
| | Other_sequence | CRC04864_1 |
| | | EX550743.1 |
| | | ACC17829_1 |
| | | CR10632 |
| | Associated_feature (11) |
| Experimental_info | RNAi_result (62) |
| | Expr_pattern (17) |
| | Drives_construct | WBCnstr00002300 |
| | | WBCnstr00004298 |
| | | WBCnstr00018249 |
| | | WBCnstr00018250 |
| | | WBCnstr00019082 |
| | | WBCnstr00020991 |
| | | WBCnstr00037146 |
| | Construct_product | WBCnstr00009770 |
| | | WBCnstr00009776 |
| | | WBCnstr00018249 |
| | | WBCnstr00018250 |
| | | WBCnstr00020274 |
| | | WBCnstr00020991 |
| | | WBCnstr00037146 |
| | | WBCnstr00039348 |
| | Regulate_expr_cluster | WBPaper00055334:DLC-1_interacting |
| | Antibody | WBAntibody00001980 |
| | Microarray_results (25) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00033070:Elbe_upregulated |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037946:MAB-5_interacting |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:stress_upregulated_N2 |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00041072:UTX-1_interacting_protein |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044616:alg-3-4_upregulated_gene |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_upregulated_HeatShock |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050686:glp-1(e2141)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:body-wall-muscle_nucleus_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_nucleus_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053810:clk-1(qm30)_downregulated |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00053814:25C_downregulated_OP50 |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00055049:S.gordonii_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056275:P.aeruginosa_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00056900:PID-3_interacting |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_protein |
| | | WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061274:microgravity_upregulated |
| | | WBPaper00061340:BWM_anterior |
| | | WBPaper00061340:BWM_far_posterior |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:arf-1.2_3224-trap-2_2175 |
| | | WBPaper00061527:C28H8.4-ZK418.5_10918 |
| | | WBPaper00061651:Germline_enriched |
| | | WBPaper00061651:Rectal_gland_enriched |
| | | WBPaper00061651:Spermatheca_enriched |
| | | WBPaper00061902:CAMT-1_interacting |
| | | WBPaper00062056:lin-15B(n744)_downregulated |
| | | WBPaper00062143:PQN-59_interacting |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00063976:micu-1(bon20)_downregulated |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_4_5 |
| | | cgc4489_group_4 |
| | | WBPaper00025032:cluster_89 |
| | | WBPaper00025099:MA_specific |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00032948:FedUp |
| | | WBPaper00034739:TreatmentAffectedGenes |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042128:gei-8(ok1671)_downregulated |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00048624:hlh-25(ok1710)_upregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_22 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(23_min) |
| | | [cgc5767]:expression_class_SM |
| | | [cgc5767]:expression_class_SMD |
| | Interaction (296) |
| Map_info | Map | III | Position | -1.25437 | Error | 0.00201 |
| | Positive | Positive_clone | T26A5 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (43) |
| Remark | T25A5.9 is a misprint for T26A5.9. changing cosmid and sequence. [sdm 000921] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
