| WBGene00001842 | SMap | S_parent | Sequence | ZK287 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | her-1 | Person_evidence | WBPerson261 |
| | | Sequence_name | ZK287.8 |
| | | Molecular_name | ZK287.8a |
| | | | ZK287.8a.1 |
| | | | CE06617 |
| | | | ZK287.8b |
| | | | CE46124 |
| | | | ZK287.8b.1 |
| | | Other_name | CELE_ZK287.8 | Accession_evidence | NDB | BX284605 |
| | | Public_name | her-1 |
| | DB_info | Database (10) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | her |
| | Reference_allele | WBVar00144068 |
| | | WBVar00089681 |
| | Allele (115) |
| | Legacy_information | Class 1 (loss-of-function) : e1518 : XX animals wildtype XO animals transformed into fertile hermaphrodites. ES3 (XO). Similar phenotype in e1518/Df. NA > 12 (e1520 e1561ts etc.). |
| | | Class 2 (gain-of-function) : n695sd ts : XO animals wildtype XX animals partly masculinized egglaying defective hermaphrodites; n695/+ XX animals slightly masculinized. ES2 (XX). NA1. Intragenic revertants have Class 1 phenotype. NA (ird) > 4. |
| | | See also e1518, e1519, e1520, e2296, n695, n826, n827, y8, y10, y14 |
| | | [C.elegansII] e1518 : XX animals WT, XO animals transformed into fertile hermaphrodites. ES3 (XO). Similar phenotype in e1518/Df. OA>20: e1520, e1561ts (XO fertile male 15C, fertile hermaphrodite25C), q428ts (very weak Her), etc. Also gain-of-function alleles: n695sd,ts(XO animals WT, XX animals partly masculinized Egl hermaphrodites; n695/+ XX animals slightly masculinized),y101 (stronger masculinization, still incomplete). Intragenic revertants are recessive Her-1 alleles:n695n826, y1hv101 (viable deletion), etc. ES2 (XX). NA1. Intragenic revertants have Class 1 phenotype. Cloned: 0.8 and 1.2 kb transcripts, XO specific;1.2 kb transcript necessary and sufficient, encodes175 aa predicted cysteine-rich novel protein with signal sequence. [Hodgkin 1980; Perry et al. 1993, 1994; NT; PA] |
| | Strain (11) |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00044186 |
| | | 00044187 |
| | | 00044188 |
| | | 00044189 |
| | | 00044190 |
| | | 00044191 |
| | Ortholog (26) |
| | Structured_description | Concise_description | her-1 generates two transcripts, the larger of which encodes a small,secreted, cysteine-rich protein (HER-1A) required for normal sexdetermination in wild-type XO male animals, while being dispensable forsex determination in XX hermaphrodites; transcription of her-1 in XXanimals is repressed by SDC-2; HER-1A protein has two all-helicaldomains, with fourteen conserved cysteine residues forming sevendisulfide bonds, at least eight of which residues are critical forfunction in vivo; HER-1A has no known homologs except in other nematodes(e.g., Brugia malayi), and does not structurally resemble otherwell-known secreted proteins; HER-1A inhibits the receptor TRA-2A invivo, and binds it in vitro; HER-1A functions nonautonomously andrequires a signal sequence for biological activity; the her-1(n695gf)mutation alters a site in the her-1 promoter bound by SDC-2, partiallytransforms XX animals into phenotypic males, and requires sup-26 andsup-27 to do so. | Paper_evidence | WBPaper00000498 |
| | | | | | WBPaper00001067 |
| | | | | | WBPaper00001416 |
| | | | | | WBPaper00001496 |
| | | | | | WBPaper00001692 |
| | | | | | WBPaper00002034 |
| | | | | | WBPaper00003644 |
| | | | | | WBPaper00005215 |
| | | | | | WBPaper00005578 |
| | | | | | WBPaper00024344 |
| | | | | Person_evidence | WBPerson479 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 13 Feb 2007 00:00:00 |
| | | Automated_description | Enables signaling receptor binding activity. Involved in male sex determination. Located in extracellular region. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | ZK287.8a |
| | | ZK287.8b |
| | Corresponding_CDS_history | ZK287.8b:wp227 |
| | Corresponding_transcript | ZK287.8a.1 |
| | | ZK287.8b.1 |
| | Other_sequence | FD515802.1 |
| | | CSC02098_1 |
| | Associated_feature | WBsf019092 |
| | | WBsf019093 |
| | | WBsf647101 |
| | | WBsf661583 |
| | | WBsf1000974 |
| | | WBsf1000975 |
| | | WBsf1000976 |
| | | WBsf1020212 |
| | | WBsf1020213 |
| Experimental_info | RNAi_result | WBRNAi00021950 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00059334 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00087454 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00030278 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1391 |
| | | Expr1019921 |
| | | Expr1162763 |
| | | Expr2012399 |
| | | Expr2030635 |
| | Drives_construct | WBCnstr00000369 |
| | | WBCnstr00000370 |
| | | WBCnstr00036652 |
| | Construct_product | WBCnstr00036652 |
| | | WBCnstr00040211 |
| | Microarray_results (27) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:BAG-neuron_embryo_enriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00038061:aldicarb_upregulated |
| | | WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray |
| | | WBPaper00044316:CH3HgCl_2.0uM_upregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00045050:csr-1(hypomorph)_upregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set1 |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set2 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049377:MWCNT_downregulated |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050163:let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053318:Aging_upregulated_mRNA_N2 |
| | | WBPaper00053888:drh-3(rrr2)_upregulated |
| | | WBPaper00054493:hpl-2(tm1489)_downregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_L1 |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_L2 |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_L3 |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:wdr-5(ok1417)_upregulated |
| | | WBPaper00059253:sucrose_stearic-acid_upregulated |
| | | WBPaper00059334:sacy-1(depletion)_regulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060526:plp-1(ok2155)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060764:swsn-1(os22ts)_downregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ABarpaaa_lineage |
| | | WBPaper00061340:ADL_parent |
| | | WBPaper00061340:AIN_parent |
| | | WBPaper00061340:Body_wall_muscle |
| | | WBPaper00061340:Ciliated_amphid_neuron |
| | | WBPaper00061340:Ciliated_non_amphid_neuron |
| | | WBPaper00061340:Neuroblast_ALA_RMED |
| | | WBPaper00061340:Neuroblast_ASE_ASJ_AUA |
| | | WBPaper00061340:Neuroblast_BAG_SMDVx |
| | | WBPaper00061340:OLL |
| | | WBPaper00061340:OLQ_parent |
| | | WBPaper00061340:Parents_of_PHsh_hyp8_hyp9 |
| | | WBPaper00061340:Parents_of_U_F_B_DVA |
| | | WBPaper00061340:Parents_of_Y_DA6_DA7_DA9 |
| | | WBPaper00061340:RIC |
| | | WBPaper00061340:RID_parent |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:sdz-10-fbxb-62 |
| | | WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated |
| | | WBPaper00061753:csr-1(tor159)_downregulated_20C |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_transcript |
| | | WBPaper00062456:doxycycline_downregulated_N2_transcript |
| | | WBPaper00062520:qui-1(db104)_downregulated |
| | | WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00065005:sams-3(RNAi)_downregulated |
| | | WBPaper00065005:sams-4(RNAi)_downregulated |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_20 |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00042274:tbx-2(bx59)_upregulated |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045673:colistin_downregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(101_min) |
| | | [cgc5767]:expression_class_E_pi(101_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SET |
| | | [cgc5767]:expression_class_SE_pi(101_min) |
| | | [cgc6390]:male_soma-enriched |
| | Interaction (125) |
| | WBProcess | WBbiopr:00000056 |
| Map_info | Map | V | Position | 2.07413 | Error | 0.004197 |
| | Well_ordered |
| | Positive | Inside_rearr | nDf31 |
| | | | ctDp11 |
| | | Positive_clone | CT#4 |
| | | | ZK287 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 633 |
| | | | 634 |
| | | Multi_point | 329 |
| | | | 544 |
| | | | 545 |
| | | | 546 |
| | | | 547 |
| | | | 739 |
| | | | 1786 |
| | | | 3892 |
| | | Pos_neg_data | 378 |
| | | | 1736 |
| | | | 1737 |
| Reference (253) |
| Picture | WBPicture0000013095 |
| Method | Gene |
