| WBGene00004789 | SMap | S_parent | Sequence | W10G6 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | sgk-1 | Person_evidence | WBPerson50 |
| | | Sequence_name | W10G6.2 |
| | | Molecular_name | W10G6.2a |
| | | | W10G6.2a.1 |
| | | | CE39527 |
| | | | W10G6.2b |
| | | | CE39528 |
| | | | W10G6.2a.2 |
| | | | W10G6.2b.1 |
| | | Other_name | tag-74 | CGC_data_submission |
| | | | CELE_W10G6.2 | Accession_evidence | NDB | BX284606 |
| | | Public_name | sgk-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | sgk |
| | Allele (164) |
| | Strain | WBStrain00003895 |
| | | WBStrain00023654 |
| | | WBStrain00023656 |
| | | WBStrain00035695 |
| | | WBStrain00048359 |
| | RNASeq_FPKM (74) |
| | GO_annotation (39) |
| | Ortholog (43) |
| | Paralog (15) |
| | Structured_description | Concise_description | sgk-1 encodes a serine/threonine protein kinase that is orthologous to the mammalian serum- and glucocorticoid-inducible kinases (SGKs); in C. elegans, sgk-1 activity is required for normal egg laying, generation time, stress response, and adult life span; SGK-1 forms a complex with the AKT kinases with which it functions in parallel to mediate certain aspects of DAF-2/insulin-signaling; SGK-1 phosphorylates DAF-16 in vitro in a manner strictly dependent upon pdk-1 which encodes a 3-phosphoinositide-dependent kinase; an SGK-1::GFP fusion protein is expressed beginning in late embryonic stages and in larvae is seen in sensory and motor neurons as well as in the intestine; in neurons SGK-1::GFP localizes to the cytoplasm and the nucleus, while in the intestine SGK-1::GFP is found exclusively in the cytoplasm. | Paper_evidence | WBPaper00013413 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 12 Oct 2007 00:00:00 |
| | | Automated_description | Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in several processes, including mesendoderm development; positive regulation of vitellogenesis; and regulation of protein localization to basolateral plasma membrane. Located in cytoplasm and nucleus. Expressed in intestine; neurons; and tail neurons. Human ortholog(s) of this gene implicated in cystadenocarcinoma (multiple); granulosa cell tumor; and hypertension. Is an ortholog of human C8orf44-SGK3 (C8orf44-SGK3 readthrough); SGK2 (serum/glucocorticoid regulated kinase 2); and SGK3 (serum/glucocorticoid regulated kinase family member 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:3603 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10810) |
| | | DOID:2999 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10810) |
| | | DOID:3114 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10810) |
| | | DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10810) |
| Molecular_info | Corresponding_CDS | W10G6.2a |
| | | W10G6.2b |
| | Corresponding_CDS_history | W10G6.2:wp152 |
| | Corresponding_transcript | W10G6.2a.1 |
| | | W10G6.2a.2 |
| | | W10G6.2b.1 |
| | Other_sequence (65) |
| | Associated_feature | WBsf654686 |
| | | WBsf671425 |
| | | WBsf671426 |
| | | WBsf671427 |
| | | WBsf238384 |
| Experimental_info | RNAi_result (44) |
| | Expr_pattern | Expr2920 |
| | | Expr12360 |
| | | Expr13383 |
| | | Expr13384 |
| | | Expr1028504 |
| | | Expr1032376 |
| | | Expr1158648 |
| | | Expr2015802 |
| | | Expr2034035 |
| | Drives_construct | WBCnstr00000182 |
| | | WBCnstr00020685 |
| | | WBCnstr00022723 |
| | | WBCnstr00035387 |
| | | WBCnstr00039281 |
| | | WBCnstr00039282 |
| | Construct_product | WBCnstr00000182 |
| | | WBCnstr00017996 |
| | | WBCnstr00020685 |
| | | WBCnstr00035387 |
| | Antibody | WBAntibody00001662 |
| | Microarray_results (23) |
| | Expression_cluster | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:intestine_CoreEnriched |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00037950:intestine_embryo_SelectivelyEnriched |
| | | WBPaper00037950:intestine_larva_enriched |
| | | WBPaper00037950:intestine_larva_SelectivelyEnriched |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045314:S.aureus-induced_N2 |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045861:set-2(ok952)_upregulated |
| | | WBPaper00046121:endoderm_unique |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046499:AMPK_regulated |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048971:daf-16(mgDf50)_upregulated_L1 |
| | | WBPaper00049334:CE_intestine_enriched |
| | | WBPaper00049368:daf-2(e1370)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050080:rbr-2(tm3141)_upregulated |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051265:F4_hrde-1(tm1200)_downregulated |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056284:ints-9(RNAi)_downregulated |
| | | WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060084:cco-1(RNAi)_downregulated_lin-40(yth27) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_mRNA |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_protein |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Intestine |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:F54D5.3_7003-F54D5.3_7004 |
| | | WBPaper00061530:nhr-49(e2144)_upregulated |
| | | WBPaper00061651:PVC_enriched |
| | | WBPaper00062056:lin-36(we31)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064735:bet-1B(OE)_vs_N2_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:3_4 |
| | | WBPaper00065841:30_0 |
| | | WBPaper00065841:30_3 |
| | | WBPaper00065841:73_0 |
| | | WBPaper00065945:global-rpoa-2(-)_downregulated_transcript |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00024393:strongly_regulated_dauer_genes |
| | | WBPaper00025032:cluster_174 |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_4 |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035479:daf-16(RNAi)_upregulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00040184:hcf-1down_sir-2.1down_daf-2down |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00045263:ProLongevity-mtROS_downregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(143_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(143_min) |
| | | [cgc6390]:Cluster_B |
| | Interaction (216) |
| | WBProcess | WBbiopr:00000001 |
| | | WBbiopr:00000039 |
| | | WBbiopr:00000074 |
| Map_info | Map | X | Position | 23.6985 | Error | 0.006601 |
| | Positive | Positive_clone | W10G6 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4658 |
| | Pseudo_map_position |
| Reference (96) |
| Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
