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WormBase Tree Display for Gene: WBGene00006661

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Name Class

WBGene00006661EvidencePerson_evidenceWBPerson655
SMapS_parentSequenceF17C8
IdentityVersion1
NameCGC_nametwk-6Person_evidenceWBPerson655
Sequence_nameF17C8.5
Molecular_nameF17C8.5
F17C8.5.1
CE00959
Other_nametwk-5Person_evidenceWBPerson655
CELE_F17C8.5Accession_evidenceNDBBX284603
Public_nametwk-6
DB_infoDatabaseAceViewgene3F833
WormQTLgeneWBGene00006661
WormFluxgeneWBGene00006661
NDBlocus_tagCELE_F17C8.5
PanthergeneCAEEL|WormBase=WBGene00006661|UniProtKB=Q19525
familyPTHR11003
NCBIgene192070
RefSeqproteinNM_065572.2
TREEFAMTREEFAM_IDTF352531
TrEMBLUniProtAccQ19525
UniProt_GCRPUniProtAccQ19525
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classtwk
Allele (18)
Legacy_information[Thomas JH] twk for potassium channel family, type Twik (double P domain)
StrainWBStrain00002198
WBStrain00002544
RNASeq_FPKM (74)
GO_annotation (11)
Ortholog (34)
Paralog (48)
Structured_descriptionConcise_descriptiontwk-6 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; as loss of TWK-6 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of TWK-6 in C. elegans development and/or behavior is not yet known; TWK-6 may, however, function redundantly with other TWK channels; TWK-6 is expressed in the hypodermis.Paper_evidenceWBPaper00004403
WBPaper00004644
WBPaper00005654
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Expressed in hypodermis and tail. Is an ortholog of several human genes including KCNK2 (potassium two pore domain channel subfamily K member 2); KCNK4 (potassium two pore domain channel subfamily K member 4); and KCNK5 (potassium two pore domain channel subfamily K member 5).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSF17C8.5
Corresponding_transcriptF17C8.5.1
Experimental_infoRNAi_resultWBRNAi00041365Inferred_automaticallyRNAi_primary
WBRNAi00044886Inferred_automaticallyRNAi_primary
WBRNAi00031073Inferred_automaticallyRNAi_primary
WBRNAi00041364Inferred_automaticallyRNAi_primary
WBRNAi00005129Inferred_automaticallyRNAi_primary
WBRNAi00005809Inferred_automaticallyRNAi_primary
WBRNAi00013466Inferred_automaticallyRNAi_primary
WBRNAi00006783Inferred_automaticallyRNAi_primary
WBRNAi00011270Inferred_automaticallyRNAi_primary
Expr_patternChronogram1721
Expr1367
Expr5784
Expr5785
Expr1013050
Expr1148852
Expr2017678
Expr2035816
Drives_constructWBCnstr00002941
WBCnstr00004465
WBCnstr00010240
WBCnstr00034233
Construct_productWBCnstr00010240
WBCnstr00034233
Microarray_results (18)
Expression_clusterWBPaper00029359_1166
WBPaper00029359_1197
WBPaper00029359_1291
WBPaper00029359_1546
WBPaper00033070:Elbe_downregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00041071:spe-44_downregulated
WBPaper00042194:Tryptophan_downregulated
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00044316:CH3HgCl_7.5uM_upregulated
WBPaper00044736:rising_dev_expression
WBPaper00044760:germline_specific
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
WBPaper00045390:tunicamycin_upregulated
WBPaper00045390:ubc-9(RNAi)_upregulated
WBPaper00045521:Spermatogenic
WBPaper00045774:clk-1_upregulated
WBPaper00046805:csr-1(RNAi)_upregulated_Set1
WBPaper00048611:MnCl2_downregulated
WBPaper00049489:AMsh-glia_enriched
WBPaper00049498:npr-1(ur89)_regulated_1
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050231:male_enriched
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:hypodermis_enriched
WBPaper00050990:hypodermis_expressed
WBPaper00053318:Aging_downregulated_mRNA_N2
WBPaper00053599:female_vs_male_downregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055354:Allantoin_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Metformin_upregulated
WBPaper00055354:Psora_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Psora_downregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055386:eat-2(ad465)_upregulated
WBPaper00055648:sperm_expressed
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056161:male_enriched_siRNA
WBPaper00056169:rrf-3(pk1426)_upregulated_adult
WBPaper00056169:rrf-3(pk1426)_upregulated_L4
WBPaper00056284:ints-2(RNAi)_upregulated
WBPaper00056290:hsp-6(mg585)_downregulated
WBPaper00057068:numr-1(RNAi)_upregulated_Cadmium
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058955:heatshock_upregulated_CE
WBPaper00059117:B.subtilis_upregulated
WBPaper00059728:5ug_cholesterol_upregulated
WBPaper00059728:20ug_cholesterol_upregulated
WBPaper00059754:E.faecalis_OG1RF_upregulated
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061424:Diet_MYb120_upregulated
WBPaper00061424:Diet_MYb131_upregulated
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061527:C34B2.3_17388-T01C3.5
WBPaper00062156:jmjd-5(zr1234)_upregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062456:doxycycline_upregulated_CB4856_transcript
WBPaper00062456:doxycycline_upregulated_N2_transcript
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064716:paraquat_downregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C
WBPaper00065984:pals-17(syb3980)_upregulated
WBPaper00065995:M.humicola-extract_upregulated_N2
WBPaper00066038:mip-1(how5)_upregulated
WBPaper00066110:Cisplatin_upregulated_diploid
WBPaper00066110:Doxorubicin_upregulated_diploid
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066232:ash-2(RNAi)_downregulated_WT
cgc4489_group_16
cgc4489_male_enriched_neuronal_genes
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00030985:Erwinia_carotovora_downregulated
WBPaper00036123:Fluoranthene_regulated
WBPaper00036286:Pattern_E
WBPaper00038172:aak-2overexpression_up_regulated
WBPaper00040858:eQTL_regulated_old
WBPaper00045263:0.1mM-paraquat_downregulated
WBPaper00045263:isp-1(qm150)_downregulated
WBPaper00045263:nuo-6(qm200)_downregulated
WBPaper00045263:ProLongevity-mtROS_downregulated
WBPaper00045673:colistin_downregulated
WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
[cgc6390]:male_germline-enriched
InteractionWBInteraction000345318
WBInteraction000503139
Map_infoMapIIIPosition-2.61078Error0.003023
PositivePositive_cloneF17C8Person_evidenceWBPerson654
WBPerson655
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00026748
Remarktwk-6 was connected to F19D8.1Person_evidenceWBPerson655
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene