| WBGene00008419 | SMap | S_parent | Sequence | D2030 |
|---|
| Identity | Version | 3 |
| | Name | CGC_name | wdr-23 | Person_evidence | WBPerson590 |
| | | Sequence_name | D2030.9 |
| | | Molecular_name (16) |
| | | Other_name | xrep-1 | Paper_evidence | WBPaper00036411 |
| | | | | Person_evidence | WBPerson1284 |
| | | | CELE_D2030.9 | Accession_evidence | NDB | BX284601 |
| | | Public_name | wdr-23 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:49 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 2 | 26 Mar 2007 13:57:19 | WBPerson2970 | Name_change | CGC_name | wdr-23 |
| | | | 3 | 01 Oct 2010 14:04:48 | WBPerson2970 | Name_change | Other_name | xrep-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | wdr |
| | Allele (92) |
| | Strain | WBStrain00001583 |
| | | WBStrain00001735 |
| | | WBStrain00005859 |
| | | WBStrain00005861 |
| | | WBStrain00055405 |
| | RNASeq_FPKM (74) |
| | GO_annotation (26) |
| | Contained_in_operon | CEOP1408 |
| | Ortholog (33) |
| | Structured_description | Concise_description | wdr-23 encodes a WD40 repeat-containing protein; WDR-23 functions as part of a CUL-4/DDB-1 ubiquitin ligase complex that negatively regulates accumulation and hence, transcriptional activation activity of the SKN-1 transcription factor in intestinal nuclei; wdr-23 activity is thus required for regulation of stress resistance, longevity, and normal growth and development; WDR-23 physically interacts with DDB-1 and SKN-1, thus likely serving as a bridge between the ubiquitin ligase complex and its SKN-1 substrate; in regulating skn-1 function, wdr-23 appears to act downstream of the p38 MAPK pathway and together with gsk-3 and the daf-2-mediated insulin signaling pathway; WDR-23 is expressed in the intestine, hypodermis, and neurons, where it localizes to nuclei. | Paper_evidence | WBPaper00032980 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 06 Apr 2010 00:00:00 |
| | | Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of cellular response to manganese ion; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in several cellular components, including intracellular membrane-bounded organelle; neuronal cell body; and striated muscle dense body. Expressed in ASIL; ASIR; head; muscle cell; and tail. Is an ortholog of human DCAF11 (DDB1 and CUL4 associated factor 11). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | D2030.9a |
| | | D2030.9b |
| | | D2030.9c |
| | | D2030.9d |
| | | D2030.9e |
| | Corresponding_transcript | D2030.9a.1 |
| | | D2030.9a.2 |
| | | D2030.9b.1 |
| | | D2030.9c.1 |
| | | D2030.9d.1 |
| | | D2030.9e.1 |
| | Other_sequence (26) |
| | Associated_feature (17) |
| Experimental_info | RNAi_result (54) |
| | Expr_pattern (17) |
| | Drives_construct (12) |
| | Construct_product (14) |
| | Regulate_expr_cluster | WBPaper00042215:wdr-23(tm1817)_downregulated |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044743:wdr-23_neuron_upregulated |
| | | WBPaper00059566:wdr-23(mac32)_downregulated |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | Microarray_results (40) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045257:bar-1(ga80)_upregulated |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050468:hlh-30-dependent_Cry5B_regulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053810:clk-1(qm30)_upregulated |
| | | WBPaper00053810:isp-1(qm150)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056275:P.aeruginosa_upregulated |
| | | WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00057254:MWCNT_downregulated_mRNA |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058711:skn-1(lax188)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059604:fluvastatin_downregulated_N2 |
| | | WBPaper00059754:E.faecalis_OG1RF_upregulated |
| | | WBPaper00059754:P.aeruginosa_PA14_upregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061390:daf-22(ok693)_ascarosides_upregulated |
| | | WBPaper00061527:cdc-42_17192-rab-5_18073 |
| | | WBPaper00061651:ASK_enriched |
| | | WBPaper00061651:BDU_enriched |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064505:tamoxifen_upregulated |
| | | WBPaper00064532:pals-25(icb98)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00005124:testosterone_10-9M_regulated |
| | | WBPaper00006465:II_ethanol_late_induction |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_4 |
| | | WBPaper00025099:MA_specific |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031184:acrylamide_upregulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00032948:StarveUp2 |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00037113:Diazinon_16C_regulated |
| | | WBPaper00037611:GLD-2-associated |
| | | WBPaper00037611:RNP-8-associated |
| | | WBPaper00038231:Cry5B_1.5-fold_upregulated |
| | | WBPaper00039866:ClassComp_daf-19_downregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040963:TA100_down |
| | | WBPaper00040963:TA200_down |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041906:I-4317_vs_OP50_10d |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045263:ProLongevity-mtROS_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo |
| | | WBPaper00055899:nitrotriazolone_regulated |
| | | [cgc5767]:cluster_3 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(53_min) |
| | | [cgc5767]:expression_class_SM |
| | | [cgc5767]:expression_class_SMD |
| | | [cgc6390]:Cluster_E |
| | Interaction (42) |
| Map_info | Map | I | Position | 2.19591 | Error | 0.005029 |
| | Positive | Positive_clone | D2030 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (48) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
