WormBase Tree Display for Gene: WBGene00000064
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WBGene00000064 | SMap | S_parent | Sequence | T04C12 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | act-2 | Person_evidence | WBPerson259 | |||||
Sequence_name | T04C12.5 | ||||||||
Molecular_name | T04C12.5 | ||||||||
T04C12.5.1 | |||||||||
CE13150 | |||||||||
Other_name | act2 | Accession_evidence | EMBL | X16797 | |||||
CELE_T04C12.5 | Accession_evidence | NDB | BX284605 | ||||||
Public_name | act-2 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | act | ||||||||
Allele (25) | |||||||||
Strain | WBStrain00031881 | ||||||||
WBStrain00005465 | |||||||||
WBStrain00007342 | |||||||||
WBStrain00007350 | |||||||||
WBStrain00007351 | |||||||||
WBStrain00007357 | |||||||||
WBStrain00007359 | |||||||||
In_cluster | act-123 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation | 00039098 | ||||||||
00039099 | |||||||||
00039100 | |||||||||
00039101 | |||||||||
00039102 | |||||||||
00039103 | |||||||||
00039104 | |||||||||
00039105 | |||||||||
00039106 | |||||||||
00039107 | |||||||||
00039108 | |||||||||
00039109 | |||||||||
00039110 | |||||||||
00039111 | |||||||||
00039112 | |||||||||
00039113 | |||||||||
00039114 | |||||||||
00039115 | |||||||||
00039116 | |||||||||
00039117 | |||||||||
00039118 | |||||||||
Ortholog (57) | |||||||||
Paralog (11) | |||||||||
Structured_description | Concise_description | act-2 encodes one of five C. elegans actins; act-2 functions redundantly in early embryonic cortical microfilaments with act-1 and act-3, and dominant mutations in act-2 result in uncoordinated locomotion; an ACT-2::GFP reporter fusion is expressed in the cytoplasm of embryonic cells and is also found in contractile filaments in adult muscle cells. | Paper_evidence | WBPaper00001178 | |||||
WBPaper00001709 | |||||||||
WBPaper00027028 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 29 May 2013 00:00:00 | ||||||||
Automated_description | Predicted to enable ATP binding activity. Involved in several processes, including cortical actin cytoskeleton organization; cytoskeleton-dependent cytokinesis; and embryo development. Located in actin filament and cell cortex. Expressed in body wall musculature; gonad; hypodermis; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; and autosomal dominant nonsyndromic deafness 20. Is an ortholog of human ACTB (actin beta). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:1588 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:132) | ||||
DOID:0081113 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:144) | ||||||
DOID:10881 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:132) | ||||||
DOID:0081112 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:132) | ||||||
DOID:0110550 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:144) | ||||||
Molecular_info | Corresponding_CDS | T04C12.5 | |||||||
Corresponding_transcript | T04C12.5.1 | ||||||||
Other_sequence (476) | |||||||||
Associated_feature (16) | |||||||||
Experimental_info | RNAi_result (49) | ||||||||
Expr_pattern | Expr3813 | ||||||||
Expr4555 | |||||||||
Expr1030025 | |||||||||
Expr1155999 | |||||||||
Expr2009222 | |||||||||
Expr2027459 | |||||||||
Drives_construct | WBCnstr00011672 | ||||||||
WBCnstr00016094 | |||||||||
WBCnstr00037759 | |||||||||
Construct_product | WBCnstr00011672 | ||||||||
WBCnstr00016094 | |||||||||
WBCnstr00037759 | |||||||||
Antibody | WBAntibody00001783 | ||||||||
Microarray_results (23) | |||||||||
Expression_cluster (206) | |||||||||
Interaction (415) | |||||||||
WBProcess | WBbiopr:00000096 | ||||||||
Map_info (3) | |||||||||
Reference (62) | |||||||||
Remark | M03F4.2 connection removed since latter is on another chromosome. [sdm 0107] | ||||||||
Sequences T04C12.4 & T04C12.6 removed. email from JAH 0109 | |||||||||
Method | Gene |