WormBase Tree Display for Gene: WBGene00010251
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| WBGene00010251 | SMap | S_parent | Sequence | F58E6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | sta-2 | Person_evidence | WBPerson168 | |||||
| Sequence_name | F58E6.1 | ||||||||
| Molecular_name | F58E6.1 | ||||||||
| F58E6.1.1 | |||||||||
| CE42515 | |||||||||
| Other_name | CELE_F58E6.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | sta-2 | ||||||||
| DB_info | Database | AceView | gene | 5K227 | |||||
| 5K225 | |||||||||
| WormQTL | gene | WBGene00010251 | |||||||
| WormFlux | gene | WBGene00010251 | |||||||
| NDB | locus_tag | CELE_F58E6.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00010251|UniProtKB=Q20977 | |||||||
| family | PTHR11801 | ||||||||
| NCBI | gene | 3565291 | |||||||
| RefSeq | protein | NM_001129491.3 | |||||||
| SwissProt | UniProtAcc | Q20977 | |||||||
| UniProt_GCRP | UniProtAcc | Q20977 | |||||||
| OMIM | gene | 102582 | |||||||
| 600555 | |||||||||
| 600558 | |||||||||
| 604260 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 27 Mar 2008 16:32:26 | WBPerson4025 | Event | Split_into | WBGene00077697 | ||||
| 3 | 26 Nov 2009 11:16:28 | WBPerson9133 | Name_change | CGC_name | sta-2 | ||||
| Split_into | WBGene00077696 | ||||||||
| WBGene00077697 | |||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sta | ||||||||
| Allele (32) | |||||||||
| Strain | WBStrain00032243 | ||||||||
| WBStrain00021985 | |||||||||
| WBStrain00021988 | |||||||||
| WBStrain00047518 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00069833 | ||||||||
| 00069834 | |||||||||
| 00069835 | |||||||||
| 00069836 | |||||||||
| 00069837 | |||||||||
| 00069838 | |||||||||
| 00069839 | |||||||||
| 00069840 | |||||||||
| 00069841 | |||||||||
| 00069842 | |||||||||
| 00069843 | |||||||||
| 00069844 | |||||||||
| 00069845 | |||||||||
| 00069846 | |||||||||
| 00069847 | |||||||||
| 00069848 | |||||||||
| 00069849 | |||||||||
| 00069850 | |||||||||
| 00069851 | |||||||||
| 00069852 | |||||||||
| 00069853 | |||||||||
| 00069854 | |||||||||
| 00069855 | |||||||||
| 00069856 | |||||||||
| 00117687 | |||||||||
| 00117688 | |||||||||
| 00117689 | |||||||||
| Ortholog (51) | |||||||||
| Paralog | WBGene00013111 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sta-2 encodes a member of the STAT family of transcription factors; STA-2 functions cell autonomously together with the SNF-12 sodium-dependent neurotransmitter symporter to regulate expression of antimicrobial peptides in the epidermis following fungal infection and physical wounding; STA-2 physically interacts with SNF-12; a sta-2 reporter gene is expressed in the epidermis throughout development and in the seam cells, intestine, phasmid socket cells, excretory duct cell, vulval cells and the dorsal rectal cells; STA-2 localizes to both the nucleus and the cytoplasm; in the epidermal cytoplasm, STA-2 colocalizes with SNF-12 in endocytic-like vesicles near the apical cell surface. | Paper_evidence | WBPaper00038424 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 12 May 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to fungus; positive regulation of antifungal peptide production; and response to wounding. Located in several cellular components, including apical part of cell; endocytic vesicle; and hemidesmosome. Part of hemidesmosome associated protein complex. Expressed in hypodermis; interfacial epithelial cell; intestine; and vulva. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of several human genes including STAT1 (signal transducer and activator of transcription 1); STAT3 (signal transducer and activator of transcription 3); and STAT4 (signal transducer and activator of transcription 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (70) | ||||||||
| Molecular_info | Corresponding_CDS | F58E6.1 | |||||||
| Corresponding_CDS_history | F58E6.1:wp20 | ||||||||
| F58E6.1a:wp189 | |||||||||
| F58E6.1b:wp189 | |||||||||
| Corresponding_transcript | F58E6.1.1 | ||||||||
| Other_sequence (45) | |||||||||
| Associated_feature | WBsf647106 | ||||||||
| WBsf647107 | |||||||||
| WBsf661585 | |||||||||
| WBsf661586 | |||||||||
| Transcription_factor | WBTranscriptionFactor000235 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00095190 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00095188 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001833 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00093457 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110863 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00093455 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00095189 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015982 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00049009 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115101 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9295 | ||||||||
| Expr9296 | |||||||||
| Expr1023653 | |||||||||
| Expr1034471 | |||||||||
| Expr1152745 | |||||||||
| Expr2016952 | |||||||||
| Expr2035100 | |||||||||
| Drives_construct | WBCnstr00008724 | ||||||||
| WBCnstr00008725 | |||||||||
| WBCnstr00008726 | |||||||||
| Construct_product | WBCnstr00008727 | ||||||||
| WBCnstr00008728 | |||||||||
| WBCnstr00008729 | |||||||||
| WBCnstr00008730 | |||||||||
| WBCnstr00013880 | |||||||||
| Antibody | WBAntibody00002618 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (154) | |||||||||
| Interaction (18) | |||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| Map_info | Map | V | Position | 2.14428 | Error | 0.003978 | |||
| Positive | Positive_clone | F58E6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
