WormBase Tree Display for Gene: WBGene00002299
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WBGene00002299 | SMap | S_parent | Sequence | ZK1067 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | let-23 | Person_evidence | WBPerson533 | |||||
Sequence_name | ZK1067.1 | ||||||||
Molecular_name | ZK1067.1a | ||||||||
ZK1067.1a.1 | |||||||||
CE03840 | |||||||||
ZK1067.1b | |||||||||
CE42891 | |||||||||
ZK1067.1c | |||||||||
CE42910 | |||||||||
ZK1067.1d | |||||||||
CE50411 | |||||||||
ZK1067.1b.1 | |||||||||
ZK1067.1c.1 | |||||||||
ZK1067.1d.1 | |||||||||
Other_name | kin-7 | ||||||||
CELE_ZK1067.1 | Accession_evidence | NDB | BX284602 | ||||||
Public_name | let-23 | ||||||||
DB_info | Database (15) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | let | ||||||||
Reference_allele | WBVar00089003 | ||||||||
Allele (152) | |||||||||
Possibly_affected_by | WBVar02157233 | ||||||||
Legacy_information | mn23 : early larval lethal. NA4 (mn215 mn224 (early larval lethal) n1045 (homozygous viable cold sensitive vulvaless phenotype)). | ||||||||
See also n1045 | |||||||||
[C.elegansII] mn23 : early larval lethal. OA>15: sy15(rod-like early larval lethal, probable null), sy5 (similar tosy15, W1078op), mn224 (earlylarval lethal, non-null), n1045 (homozygousviable, Vul at 15C, weak Muv (hyperinduced) at25C; P12 transformed to P11 fate), sy1 (viable, Vul, Q1318och), sy97 (viable,Vul, ME0, abnormal spicules), sy10 (impenetrant larval lethal, survivors sterile, Emo, abnormal oocytes), etc.Alleles affect subset or all of 5 phenotypes (L1 viability, vulval induction, male spicules,oogenesis, P12). Also gf allele sa62sd (scrawny Muv, sa62/+ variable Muv, 5-50%) Cloned: 4.9 kb transcript, encodes 1323 aa EGF-receptor class tyrosine kinase (pka kin-7);let23:lacZ expressed in many but not all cells.Extensive molecular and developmental analysis.See also lfe, sli, etc. [Sigurdson et al. 1984; Aroian et al. 1990; Aroian and Sternberg 1991; Aroian et al. 1994; Koga and Ohshima 1995; FK; SP] | |||||||||
Complementation_data | [Edgley ML] Fails to complement let-23(mn23) | ||||||||
Strain (21) | |||||||||
Component_of_genotype | WBGenotype00000109 | ||||||||
WBGenotype00000110 | |||||||||
WBGenotype00000111 | |||||||||
WBGenotype00000112 | |||||||||
WBGenotype00000113 | |||||||||
WBGenotype00000114 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (51) | |||||||||
Ortholog (57) | |||||||||
Paralog (33) | |||||||||
Structured_description | Concise_description | let-23 encodes an EGF-receptor-family transmembrane tyrosine kinase that affects viability, inductive signaling during development of the vulva, male spicule formation, posterior development of the epidermis, ovulation and stress induced sleep; let-23 is genetically upstream of the let-60/RAS pathway with respect to viability and vulval development, is upstream of phosopholipase C gamma with respect to fertility and sleep, and is expressed in vulval precursor cells and the ALA neuron. | Paper_evidence | WBPaper00045813 | |||||
Person_evidence | WBPerson625 | ||||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 28 May 2015 00:00:00 | ||||||||
Automated_description | Enables epidermal growth factor receptor activity. Involved in several processes, including determination of adult lifespan; positive regulation of vulval development; and reproductive structure development. Located in cell-cell junction and plasma membrane. Expressed in several structures, including apoptotic cell; egg-laying apparatus; excretory duct cell; head; and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Is an ortholog of human EGFR (epidermal growth factor receptor) and ERBB4 (erb-b2 receptor tyrosine kinase 4). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (48) | ||||||||
Molecular_info | Corresponding_CDS | ZK1067.1a | |||||||
ZK1067.1b | |||||||||
ZK1067.1c | |||||||||
ZK1067.1d | |||||||||
Corresponding_CDS_history | ZK1067.1:wp110 | ||||||||
Corresponding_transcript | ZK1067.1a.1 | ||||||||
ZK1067.1b.1 | |||||||||
ZK1067.1c.1 | |||||||||
ZK1067.1d.1 | |||||||||
Other_sequence | X57767 | ||||||||
CR07463 | |||||||||
JI229755.1 | |||||||||
JI164844.1 | |||||||||
MHC11568_1 | |||||||||
MH06032 | |||||||||
ACC08710_1 | |||||||||
EX550763.1 | |||||||||
CRC12189_1 | |||||||||
Associated_feature | WBsf644553 | ||||||||
WBsf717766 | |||||||||
WBsf988979 | |||||||||
WBsf988980 | |||||||||
WBsf988981 | |||||||||
WBsf988982 | |||||||||
WBsf1012824 | |||||||||
WBsf1012825 | |||||||||
WBsf221857 | |||||||||
Experimental_info | RNAi_result | WBRNAi00086137 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00084770 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00111705 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069418 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00021795 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00110660 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00059089 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00078911 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00078912 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (18) | |||||||||
Drives_construct (18) | |||||||||
Construct_product (15) | |||||||||
Antibody | WBAntibody00000229 | ||||||||
WBAntibody00000972 | |||||||||
WBAntibody00001216 | |||||||||
Microarray_results (23) | |||||||||
Expression_cluster (140) | |||||||||
Interaction (645) | |||||||||
WBProcess | WBbiopr:00000020 | ||||||||
WBbiopr:00000044 | |||||||||
WBbiopr:00000067 | |||||||||
WBbiopr:00000070 | |||||||||
WBbiopr:00000071 | |||||||||
Map_info | Map | II | Position | 1.09455 | Error | 0.000258 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | mnDf61 | |||||||
mnDf62 | |||||||||
mnDf67 | |||||||||
mnDf69 | |||||||||
Positive_clone | T08E2 | ||||||||
ZK1067 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Negative | Outside_rearr | mDf17 | |||||||
Mapping_data | 2_point | 5725 | |||||||
Multi_point | 828 | ||||||||
2070 | |||||||||
3120 | |||||||||
3220 | |||||||||
3221 | |||||||||
3222 | |||||||||
3347 | |||||||||
3533 | |||||||||
4007 | |||||||||
Pos_neg_data (22) | |||||||||
Landmark_gene | |||||||||
Reference (503) | |||||||||
Method | Gene |