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WormBase Tree Display for Gene: WBGene00006787

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Name Class

WBGene00006787SMapS_parentSequenceCHROMOSOME_II
IdentityVersion2
NameCGC_nameunc-52Person_evidenceWBPerson261
Sequence_nameZC101.2
Molecular_name (49)
Other_nameCELE_ZC101.2Accession_evidenceNDBBX284602
Public_nameunc-52
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:42WBPerson1971EventImportedInitial conversion from geneace
203 Mar 2017 00:18:26WBPerson1983EventAcquires_mergeWBGene00013851
Acquires_mergeWBGene00013851
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00143214
Allele (702)
Possibly_affected_byWBVar02152950
WBVar02152951
WBVar02152902
WBVar02152903
Legacy_informatione444 : adults limp paralysed except for head region thin Egl; larvae move well; progressive dystrophy posterior muscles fail to accumulate myofilaments. ES3 (adult) ME0. NA > 10 (e669amber (well suppressed) e998 (stronger phenotype) r290 etc.).
See also e444, e669, e998, e1012, e1421
[C.elegansII] e444 : adults limp, paralysed except for head region; thin; Egl; larvae move well; progressive dystrophy, body muscles fail to accumulate myofilaments. Class 1 allele. ES3 (adult) ME0. OA>10 (class 1): e669amb (well suppressed), e998 (stronger phenotype), su200, r290 etc. Also class 2 mutations: st549 (lethal, severe Pat, no organized myofilament lattice; probable null), st546, st560 etc. (all similar to st549). Also class 3 mutation: ut111 (lethal, arrest at two-fold; not paralysed; complements class 1 alleles. See also sup-38, smu. Cloned: multiple transcripts (4.0, 6.5, 8.0 kb)g enerated by alternative RNA processing; encode proteins related to perlecan (matrix heparansulfate proteoglycan)[Rogalski et al. 1993, 1995; DM]
Strain (294)
RNASeq_FPKM (74)
GO_annotation (37)
OrthologWBGene00032251Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00145079Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00062211Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00136945Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00156793Caenorhabditis brenneriFrom_analysisTreeFam
Inparanoid_8
WBGene00097743Pristionchus pacificusFrom_analysisInparanoid_7
WBGene00099475Pristionchus pacificusFrom_analysisInparanoid_8
WormBase-Compara
WBGene00228755Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g12389Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP26.g4151Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g8092Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g20002Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g27330Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP31.g27331Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g4962Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP32.g4963Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP32.g4964Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g8473Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g20131Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g12078Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_19196.g26177Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-unc-52Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold630.g20229Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp11.Scaffold630.g20230Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp11.Scaffold630.g20231Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_03948.g31682Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_22569Caenorhabditis latensFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g12787Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g4559Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_20161610Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrII_pilon.g6587Caenorhabditis elegansFrom_analysisWormBase-Compara
chrII_pilon.g6588Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00246876Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00267333Strongyloides rattiFrom_analysisWormBase-Compara
FB:FBgn0284408Drosophila melanogasterFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-080807-4Danio rerioFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
SonicParanoid
HGNC:5273Homo sapiensFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
MGI:96257Mus musculusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
RGD:621770Rattus norvegicusFrom_analysisHieranoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ParalogWBGene00001328Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002247Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002248Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006432Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006746Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00018304Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00016913Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00020581Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionThe unc-52 gene encodes perlecan, a protein orthologous to human basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2; OMIM:142461, which when mutated leads to Schwartz-Jampel syndrome or dyssegmental dysplasia); UNC-52 plays essential roles in muscle structure development and regulation of growth factor-like signaling pathways; UNC-52 is synthesized by the hypodermis and localizes to the extracellular matrix between hypodermis and muscle.Paper_evidenceWBPaper00005261
WBPaper00005568
WBPaper00005809
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionAn extracellular matrix structural constituent. Involved in several processes, including hemidesmosome assembly; muscle cell cellular homeostasis; and muscle structure development. Located in basement membrane and striated muscle dense body. Expressed in alimentary muscle; body wall musculature; gonad; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and hyperglycemia. Is an ortholog of human HSPG2 (heparan sulfate proteoglycan 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0090032Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5273)
DOID:0090005Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5273)
DOID:4195Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5273)
DOID:3407Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5273)
DOID:2256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5273)
Molecular_infoCorresponding_CDS (16)
Corresponding_CDS_historyZC101.2d:wp274
Corresponding_transcript (17)
Other_sequence (130)
Associated_feature (48)
Experimental_infoRNAi_result (85)
Expr_pattern (12)
Drives_constructWBCnstr00002344
WBCnstr00004314
WBCnstr00034151
Construct_productWBCnstr00000996
WBCnstr00000997
WBCnstr00001000
WBCnstr00001001
WBCnstr00001002
WBCnstr00034151
AntibodyWBAntibody00000069
WBAntibody00000104
WBAntibody00000243
WBAntibody00002529
Microarray_results (76)
Expression_cluster (328)
Interaction (249)
WBProcessWBbiopr:00000006
Map_infoMapIIPosition23.3333Error0.020195
Well_ordered
PositiveInside_rearrjDf1
mnDp34
mnDp35
mnDp36
mT1
Positive_cloneRW#DM44
YK1120
ZC101Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point (19)
Multi_point (35)
Pos_neg_data (7)
Landmark_gene
Reference (256)
MethodGene