WormBase Tree Display for Gene: WBGene00004921

WBGene00004921 SMap: S_parent: Sequence: F31E8
  Identity: Version: 1
    Name: CGC_name: snt-1 Person_evidence: WBPerson508
      Sequence_name: F31E8.2
      Molecular_name: F31E8.2a
        F31E8.2a.1
        CE02711
        F31E8.2b
        CE28229
        F31E8.2b.1
      Other_name: ric-2
        unc-121
        syt1 Accession_evidence: EMBL AJ303369
        syt-1
        CELE_F31E8.2 Accession_evidence: NDB BX284602
      Public_name: snt-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: snt
    Allele (91)
    Legacy_information: [Rand JB] uncoordinated, slight shrinker, small, slow-growing, resistant to cholinesterase inhibitors.
      [C.elegansII] md125 : (pka ric-2) uncoordinated, slight shrinker, small, slow-growing, resistant to cholinesterase inhibitors; some pumping and defecation defects. OA2: ad596 (pka unc-121, Unc, worse when starved; ME2), n2665. Cloned: encodes synaptotagmin (54% identity to mammalian synaptotagmin) [Nonet et al. 1993; Nguyen et al. 1995; NM; RM]
    Complementation_data: [Rand JB] complements unc-104(e1265), egl-27(n170), let-263(mn240)
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation (41)
    Ortholog (62)
    Paralog: WBGene00004922 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00004923 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00004924 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00011682 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00004926 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00004925 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004316 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006306 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020861 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: snt-1 encodes two proteins, SNT-1A and SNT-1B, orthologous to synaptotagmin; SNT-1 is required for synaptic vesicle exocytosis and neurotransmitter release as well as for synaptic vesicle recycling via clathrin-mediated endocytosis; accordingly, snt-1 activity is required for a variety of behaviors including pharyngeal pumping, locomotion, and defecation; SNT-1A and SNT-1B isoforms are expressed in neurons, with SNT-1A typically expressed at higher levels, and in a greater number of neurons, than SNT-1B; in addition, SNT-1B is exclusively expressed in the excretory duct cell and a group of tail neurons including DVB, a GABAergic neuron required for defecation. Paper_evidence: WBPaper00001709
            WBPaper00001750
            WBPaper00002316
            WBPaper00029143
          Curator_confirmed: WBPerson1843
          Date_last_updated: 16 Apr 2007 00:00:00
      Automated_description: Enables calcium ion sensor activity and calcium-dependent phospholipid binding activity. Involved in several processes, including defecation; regulation of pharyngeal pumping; and synaptic vesicle endocytosis. Located in synaptic vesicle. Expressed in several structures, including excretory gland cell; gonad; nervous system; pharyngeal gland cell; and rectal gland cell. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 7. Is an ortholog of human SYT1 (synaptotagmin 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110659 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11510)
      DOID:3635 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11510)
  Molecular_info: Corresponding_CDS: F31E8.2a
      F31E8.2b
    Corresponding_transcript: F31E8.2a.1
      F31E8.2b.1
    Other_sequence: MI03396
      AS10851
      HS00323
      AS10727
      AS12687
      AS10904
      ACC09619_1
      AS10812
      HSC00659_1
      Tcol_isotig13120
      EY473726.1
      HBC16849_1
      HBC14703_1
      Oden_isotig19453
      FC549136.1
      XIC01345_1
      Dviv_isotig23046
      NBC03575_1
      OCC00009_1
      Acan_isotig08667
      EH005357.1
      EY462925.1
      HS01419
      OOC03685_1
      AS02845
      TSC04915_1
      EX015035.1
      ASC11813_1
      AI363551.1
      Hbac_isotig06652
      JI238718.1
      TSC05527_1
      SS02869
      JI181478.1
      Tcir_isotig30994
      FC540460.1
      EX913638.1
      ACC15582_1
      MIC02923_1
      EY466243.1
      EY461416.1
      TS00057
      NB08898
      FC548347.1
      EY466761.1
      AIC00259_1
      EY462698.1
      FC543606.1
      MJC03079_1
      FE911314.1
      MPC00168_1
      FG351955.1
      AI132733.1
      MJ03960
      EX010091.1
      SSC02101_1
      OVC00383_1
      JI475285.1
      XI03656
      MP01029
      TSC05629_1
      BE239140.1
      TS00285
      HSC00336_1
    Associated_feature (15)
  Experimental_info: RNAi_result: WBRNAi00089992 Inferred_automatically: RNAi_primary
      WBRNAi00046026 Inferred_automatically: RNAi_primary
      WBRNAi00090310 Inferred_automatically: RNAi_primary
      WBRNAi00092941 Inferred_automatically: RNAi_primary
      WBRNAi00112395 Inferred_automatically: RNAi_primary
      WBRNAi00027612 Inferred_automatically: RNAi_primary
      WBRNAi00076365 Inferred_automatically: RNAi_primary
      WBRNAi00022346 Inferred_automatically: RNAi_primary
      WBRNAi00089812 Inferred_automatically: RNAi_primary
      WBRNAi00090151 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00003269
      WBCnstr00005350
      WBCnstr00005351
      WBCnstr00009600
      WBCnstr00009601
      WBCnstr00017690
      WBCnstr00035321
      WBCnstr00038765
      WBCnstr00038766
    Construct_product: WBCnstr00001653
      WBCnstr00005350
      WBCnstr00005351
      WBCnstr00017690
      WBCnstr00019062
      WBCnstr00021442
      WBCnstr00035321
      WBCnstr00038765
      WBCnstr00038766
    Antibody: WBAntibody00000070
      WBAntibody00000152
      WBAntibody00000347
      WBAntibody00000730
      WBAntibody00000906
      WBAntibody00001655
    Microarray_results (31)
    Expression_cluster (227)
    Interaction (77)
  Map_info: Map: II Position: 0.115793 Error: 0.000262
    Well_ordered
    Positive: Positive_clone: F31E8 Inferred_automatically: From sequence, transcript, pseudogene data
        F58D4
        K10B7
    Mapping_data: 2_point: 6025
        6167
      Multi_point: 2072
        2073
        2422
        2423
        2424
      Pos_neg_data (18)
  Reference: WBPaper00001709
    WBPaper00001750
    WBPaper00001920
    WBPaper00002195
    WBPaper00002297
    WBPaper00002316
    WBPaper00002341
    WBPaper00002371
    WBPaper00002487
    WBPaper00002590
    WBPaper00002641
    WBPaper00002832
    WBPaper00002918
    WBPaper00003038
    WBPaper00003641
    WBPaper00003678
    WBPaper00003738
    WBPaper00003760
    WBPaper00003764
    WBPaper00003937
    WBPaper00004146
    WBPaper00004361
    WBPaper00004523
    WBPaper00004594
    WBPaper00004883
    WBPaper00005423
    WBPaper00005528
    WBPaper00006103
    WBPaper00006124
    WBPaper00006469
    WBPaper00006494
    WBPaper00012436
    WBPaper00012745
    WBPaper00013484
    WBPaper00014664
    WBPaper00014864
    WBPaper00015075
    WBPaper00015388
    WBPaper00015440
    WBPaper00015500
    WBPaper00015503
    WBPaper00017183
    WBPaper00017184
    WBPaper00017237
    WBPaper00017270
    WBPaper00017299
    WBPaper00017350
    WBPaper00017464
    WBPaper00017850
    WBPaper00017981
    WBPaper00018011
    WBPaper00018262
    WBPaper00018463
    WBPaper00018638
    WBPaper00019060
    WBPaper00019253
    WBPaper00019258
    WBPaper00019387
    WBPaper00021718
    WBPaper00022149
    WBPaper00022217
    WBPaper00022232
    WBPaper00022312
    WBPaper00022334
    WBPaper00022648
    WBPaper00022744
    WBPaper00023336
    WBPaper00023416
    WBPaper00024994
    WBPaper00025210
    WBPaper00026101
    WBPaper00026711
    WBPaper00026785
    WBPaper00027146
    WBPaper00027304
    WBPaper00027671
    WBPaper00027711
    WBPaper00028211
    WBPaper00028886
    WBPaper00029012
    WBPaper00029017
    WBPaper00029143
    WBPaper00030940
    WBPaper00031000
    WBPaper00031088
    WBPaper00031343
    WBPaper00032190
    WBPaper00032252
    WBPaper00032392
    WBPaper00032736
    WBPaper00033045
    WBPaper00033734
    WBPaper00036309
    WBPaper00037165
    WBPaper00037319
    WBPaper00037731
    WBPaper00038491
    WBPaper00039266
    WBPaper00039282
    WBPaper00039301
    WBPaper00040525
    WBPaper00041308
    WBPaper00042250
    WBPaper00046486
    WBPaper00048041
    WBPaper00048427
    WBPaper00048489
    WBPaper00048505
    WBPaper00048926
    WBPaper00051717
    WBPaper00054503
    WBPaper00055090
    WBPaper00061027
    WBPaper00065295
    WBPaper00065712
  Remark: [Rand JB] structural gene for synaptotagmin (cosmid hybridization by Nonet M). Null alleles viable. 14 additional md alleles exist.
  Method: Gene