WormBase Tree Display for Gene: WBGene00006810

WBGene00006810 SMap: S_parent: Sequence: C04F6
  Identity (6)
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143840
    Allele (45)
    Legacy_information: e1217 : slow abnormal body muscle birefringence abnormal muscle ultrastructure with large aggregates of thin filaments; suppressed to wildtype by sup-13. ES2 ME0. NA > 5 (e1221 st43 etc.).
      See also e1217, e1221
      [C.elegansII] e1217 : slow, abnormal body muscle birefringence, abnormal muscle ultrastructure with large aggregates of thin filaments; suppressed to wildtype by sup-13. ES2 ME0. OA>5: e1221, st43 etc. [Waterston et al. 1980]
      [S Ono] slow moving, actin filaments become aggregated in body wall muscle.
      [Ono S] unc-78 cloned, is C04F6.4 encoding homolog of actin-interacting protein 1, required for organized assembly of muscle actin filaments
    Strain: WBStrain00001852
      WBStrain00026896
      WBStrain00033511
      WBStrain00035493
      WBStrain00004274
      WBStrain00006316
    RNASeq_FPKM (74)
    GO_annotation (23)
    Ortholog (45)
    Paralog: WBGene00010685 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: unc-78 encodes a WD40 repeat-containing protein homologous to actin-interacting protein (AIP1) that regulates the ordered assembly of actin and cofilin in myofibrils; homozygous unc-78 mutant animals are viable but exhibit disorganization of actin filaments in the body wall muscle; unc-78 and aipl-1 have redundant and overlapping functions in organized assembly of actin filaments in embryonic muscle and that unc-78 and aipl-1 double mutant is embryonic lethal; both isoforms preferentially cooperate with UNC-60B, a muscle-specific ADF/cofilin for actin filament disassembly in embryonic muscle; UNC-78 is expressed in embryonic pharynx and body wall muscles; in adults it is expressed in spermatheca, the myoepithelial sheath, the uterus, adult vulva; UNC-78 isoform majorly functions in post-embryonic muscle most likely due to its expression in larval and adult muscles and that AIPL-1 can compensate for the function of UNC-78 in the body wall muscle. Paper_evidence: WBPaper00038403
          Curator_confirmed: WBPerson12884
            WBPerson567
          Date_last_updated: 12 May 2011 00:00:00
      Automated_description: Enables actin filament binding activity. Involved in several processes, including myofibril assembly; regulation of actin polymerization or depolymerization; and regulation of locomotion. Located in myofibril and sarcoplasm. Expressed in body wall musculature; pharynx; spermatheca; uterus; and vulva. Is an ortholog of human WDR1 (WD repeat domain 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C04F6.4a
    Corresponding_CDS_history: C04F6.4b:wp252
    Corresponding_transcript: C04F6.4b
      C04F6.4a.1
    Other_sequence: SRC00391_1
      OF00043
      JO467666.1
      PPC02445_1
      JI164870.1
      Oden_isotig07658
      EX551763.1
      JI481896.1
      Oden_isotig07657
      ES744585.1
      ACC15617_1
      FG977881.1
      Acan_isotig20067
      JI462554.1
      ZP00177
      SR03623
      EG025772.1
      NBC01296_1
      CJC06423_1
      ACC01506_1
      FC818890.1
      Hbac_isotig04330
      ZPC00107_1
      EX554810.1
      HBC28067_1
      Oden_isotig07656
      FK809842.1
      Oden_isotig07660
      FG353622.1
      Tcol_isotig02224
      Tcol_isotig02223
      Acan_isotig02209
      EX916160.1
      ES411502.1
      FC819313.1
      EL887611.1
      FC813158.1
      EX559491.1
      PP02109
      Tcol_isotig02221
      JI475183.1
      Oden_isotig07659
      FC814986.1
      FE913882.1
      ES411972.1
      EX911153.1
      ASC29590_1
      HBC05540_1
      Oden_isotig07654
      SR00329
      OFC01150_1
      Dviv_isotig27341
      ACC26463_1
      Tcol_isotig02222
      Oden_isotig07653
      FC814950.1
      SSC00646_1
      EY468780.1
      JI468309.1
      EG025773.1
      MIC01804_1
      FC539090.1
      CR04548
      SS02052
      Hbac_isotig01512
      Oden_isotig07655
      CR02080
      CJC01140_1
      NB10757
      HBC05572_1
      CRC02077_1
      CJC00179_1
      CR06711
      Oden_isotig07661
      PVC03428_1
    Associated_feature: WBsf653840
      WBsf653841
      WBsf1004608
      WBsf237177
      WBsf237178
  Experimental_info: RNAi_result (20)
    Expr_pattern (11)
    Drives_construct: WBCnstr00002644
      WBCnstr00011892
    Construct_product: WBCnstr00011504
      WBCnstr00011892
    Antibody: WBAntibody00000674
    Microarray_results (29)
    Expression_cluster (136)
    Interaction (63)
  Map_info: Map: X Position: -10.3431 Error: 0.00338
    Well_ordered
    Positive: Inside_rearr: yDp13
        yDp14
        yDp15
      Positive_clone: C04F6 Person_evidence: WBPerson463
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 161
      Multi_point (15)
      Pos_neg_data (18)
  Reference (43)
  Remark: Data extracted from Ono (2001)
  Method: Gene