WormBase Tree Display for Gene: WBGene00000424
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| WBGene00000424 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C09G12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ced-10 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C09G12.8 | ||||||||
| Molecular_name | C09G12.8a | ||||||||
| C09G12.8a.1 | |||||||||
| CE16832 | |||||||||
| C09G12.8B | |||||||||
| CE16833 | |||||||||
| C09G12.8b.1 | |||||||||
| Other_name | rac1 | Accession_evidence | EMBL | L03711 | |||||
| L04287 | |||||||||
| X68492 | |||||||||
| CErac1 | Paper_evidence | WBPaper00001744 | |||||||
| WBPaper00002544 | |||||||||
| C09G12.8B | Paper_evidence | WBPaper00004196 | |||||||
| CELE_C09G12.8 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | ced-10 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ced | ||||||||
| Allele (65) | |||||||||
| Legacy_information | [C.elegansII] n1993 : dying cells arrest at highly refractile stage; killer cells fail to engulf target cells; engulfment group B (ced-2,5,10 : suppressvulvaless phenotype of lin-24, lin-33);extensive maternal rescue; no gross phenotype.[Ellis et al. 1991; MT] | ||||||||
| [C.elegansII] n1993 : dying cells arrest at highly refractile stage; killer cells fail to engulf target cells; engulfment group B (ced-2,5,10 : suppress vulvaless phenotype of lin-24, lin-33);extensive maternal rescue; no gross phenotype. [Ellis et al. 1991; MT] | |||||||||
| [C.elegansII] NMK. 1.7 and 0.9 kb transcripts, encode 191 aa predicted protein with 82% identity to human rac1 (ras superfamily). [Chen et al. 1993a] | |||||||||
| Strain (17) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (93) | |||||||||
| Contained_in_operon | CEOP4088 | ||||||||
| Ortholog (45) | |||||||||
| Paralog | WBGene00000390 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00004287 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00022177 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00003239 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004357 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00009059 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00012532 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019544 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ced-10 encodes a GTPase orthologous to human RAC1 (OMIM:602048) that is required for phagocytosis during programmed cell death and for migration of the distal tip cells of the somatic gonad; CED-10 functions in the engulfing cell during apoptosis, and is activated by a complex of CED-2(CrkII) and CED-5(DOCK180) to promote formation of the polarized cell extensions associated with cell corpse engulfment. | Paper_evidence | WBPaper00003948 | |||||
| WBPaper00005200 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables GTP binding activity and GTPase activity. Involved in several processes, including axon development; establishment or maintenance of cell polarity; and regulation of cellular component organization. Located in cytoplasmic side of plasma membrane; cytoplasmic vesicle; and neuronal cell body. Expressed in several structures, including CAN; GABAergic neurons; distal tip cell; intestine; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 48; combined immunodeficiency (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human RAC1 (Rac family small GTPase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 | ||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 04 Jun 2018 00:00:00 | ||||||||
| Potential_model (18) | |||||||||
| Models_disease_asserted | WBDOannot00000558 | ||||||||
| Molecular_info | Corresponding_CDS | C09G12.8a | |||||||
| C09G12.8b | |||||||||
| Corresponding_transcript | C09G12.8a.1 | ||||||||
| C09G12.8b.1 | |||||||||
| Other_sequence (50) | |||||||||
| Associated_feature | WBsf667836 | ||||||||
| WBsf995978 | |||||||||
| WBsf995979 | |||||||||
| WBsf1017083 | |||||||||
| WBsf229890 | |||||||||
| WBsf229891 | |||||||||
| WBsf229892 | |||||||||
| WBsf229893 | |||||||||
| Experimental_info | RNAi_result (46) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct (8) | |||||||||
| Construct_product (21) | |||||||||
| Antibody | WBAntibody00000120 | ||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (88) | |||||||||
| Interaction (420) | |||||||||
| Anatomy_function | WBbtf0222 | ||||||||
| WBProcess | WBbiopr:00000013 | ||||||||
| WBbiopr:00000014 | |||||||||
| WBbiopr:00000015 | |||||||||
| WBbiopr:00000023 | |||||||||
| WBbiopr:00000107 | |||||||||
| WBbiopr:00000111 | |||||||||
| Map_info | Map | IV | Position | -3.32061 | Error | 0.028381 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C09G12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 1743 | |||||||
| 1744 | |||||||||
| 1746 | |||||||||
| Reference (316) | |||||||||
| Remark | Sequence connection from [Reddien PW, Horvitz HR] | ||||||||
| old_name rac-1 becomes new_name ced-10 from [Reddien PW, Horvitz HR]. | |||||||||
| Method | Gene |
