WormBase Tree Display for Gene: WBGene00001860
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| WBGene00001860 | Evidence | Paper_evidence | WBPaper00005919 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F28B3 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | him-1 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F28B3.7 | ||||||||
| Molecular_name | F28B3.7a | ||||||||
| F28B3.7a.1 | |||||||||
| CE42002 | |||||||||
| F28B3.7b | |||||||||
| CE39925 | |||||||||
| F28B3.7b.1 | |||||||||
| Other_name | smc-1 | Person_evidence | WBPerson421 | ||||||
| WBPerson1819 | |||||||||
| CELE_F28B3.7 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | him-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00001860 | |||||
| WormFlux | gene | WBGene00001860 | |||||||
| NDB | locus_tag | CELE_F28B3.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001860|UniProtKB=O01789 | |||||||
| family | PTHR18937 | ||||||||
| NCBI | gene | 172116 | |||||||
| RefSeq | protein | NM_001047193.6 | |||||||
| NM_001047194.3 | |||||||||
| SwissProt | UniProtAcc | O01789 | |||||||
| TREEFAM | TREEFAM_ID | TF101156 | |||||||
| UniProt_GCRP | UniProtAcc | O01789 | |||||||
| OMIM | gene | 300040 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | him | ||||||||
| Reference_allele | WBVar00143562 | ||||||||
| Allele (73) | |||||||||
| Legacy_information | e879sd : self-progeny 21% XO male; 8% ova are nullo-X as a result of reductional meiotic nondisjunction; X chromosome recombination specifically reduced 40%. e879/+ self-progeny 1% XO. ES3 (progeny). ME2. NA1. | ||||||||
| See also e879 | |||||||||
| [C.elegansII] e879sd : self-progeny 21% XO male, 5% 3X herm; 8% ova are nullo-X as a result of reductional meiotic nondisjunction; X chromosome recombination specifically reduced 40% or more, except at left end (recombination increased); Rad.e879/+ self-progeny 1% XO. ES3 (progeny). ME2. NA1. [Hodgkin et al. 1979; Broverman and Meneely 1994] | |||||||||
| Complementation_data | [Johnsen RC, Rose AM ] complements let-359(h94), let-364(h104), let-635(h688), let-638(h778), let-639(h779), let-640(h790) | ||||||||
| Strain (15) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Contained_in_operon | CEOP1208 | ||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00008085 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00001086 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00003367 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00004873 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00004874 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010306 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00012198 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016172 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019087 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00044079 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | him-1 encodes a homolog of the conserved eukaryotic protein, SMC1, a member of the SMC (structural maintenance of chromosomes) superfamily that is required for embryonic viability, germline mitosis, chromosome pairing, and the segregation of mitotic chromosomes; HIM-1 can interact with SMC-3 and is required for DPY-28 localization to meiotic chromosomes; associates with the chromatin of transition-zone nuclei. | Paper_evidence | WBPaper00005919 | |||||
| WBPaper00005937 | |||||||||
| WBPaper00018626 | |||||||||
| WBPaper00023328 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables DNA binding activity. Involved in chromosome segregation; embryo development; and response to radiation. Located in nucleus. Part of chromatin and cohesin complex. Expressed in linker cell. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2; congestive heart failure; and developmental and epileptic encephalopathy 85. Is an ortholog of human SMC1B (structural maintenance of chromosomes 1B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:6000 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11111) | ||||
| DOID:0070380 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11111) | ||||||
| DOID:0080506 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11111) | ||||||
| Molecular_info | Corresponding_CDS | F28B3.7a | |||||||
| F28B3.7b | |||||||||
| Corresponding_CDS_history | F28B3.7:wp155 | ||||||||
| F28B3.7a:wp186 | |||||||||
| Corresponding_transcript | F28B3.7a.1 | ||||||||
| F28B3.7b.1 | |||||||||
| Other_sequence (66) | |||||||||
| Associated_feature | WBsf663794 | ||||||||
| WBsf664180 | |||||||||
| WBsf664181 | |||||||||
| WBsf976678 | |||||||||
| WBsf976679 | |||||||||
| WBsf219342 | |||||||||
| Experimental_info | RNAi_result (26) | ||||||||
| Expr_pattern | Expr2599 | ||||||||
| Expr11146 | |||||||||
| Expr12737 | |||||||||
| Expr1011630 | |||||||||
| Expr1031094 | |||||||||
| Expr1149703 | |||||||||
| Expr2012427 | |||||||||
| Expr2030663 | |||||||||
| Drives_construct | WBCnstr00036643 | ||||||||
| Construct_product | WBCnstr00036643 | ||||||||
| Antibody | WBAntibody00000634 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (156) | |||||||||
| Interaction (228) | |||||||||
| WBProcess | WBbiopr:00000099 | ||||||||
| Map_info (4) | |||||||||
| Reference (51) | |||||||||
| Remark | let-526(h185) and let-127(h1880) are in the same strain (KR499) C01G8 rescues the early larval phenotype (let-526) unvailing the let-127's late larval phenotype. | ||||||||
| Method | Gene |
