WormBase Tree Display for Gene: WBGene00002299

WBGene00002299 SMap: S_parent: Sequence: ZK1067
  Identity (6)
  Gene_info: Biotype: SO:0001217
    Gene_class: let
    Reference_allele: WBVar00089003
    Allele (152)
    Possibly_affected_by: WBVar02157233
    Legacy_information: mn23 : early larval lethal. NA4 (mn215 mn224 (early larval lethal) n1045 (homozygous viable cold sensitive vulvaless phenotype)).
      See also n1045
      [C.elegansII] mn23 : early larval lethal. OA>15: sy15(rod-like early larval lethal, probable null), sy5 (similar tosy15, W1078op), mn224 (earlylarval lethal, non-null), n1045 (homozygousviable, Vul at 15C, weak Muv (hyperinduced) at25C; P12 transformed to P11 fate), sy1 (viable, Vul, Q1318och), sy97 (viable,Vul, ME0, abnormal spicules), sy10 (impenetrant larval lethal, survivors sterile, Emo, abnormal oocytes), etc.Alleles affect subset or all of 5 phenotypes (L1 viability, vulval induction, male spicules,oogenesis, P12). Also gf allele sa62sd (scrawny Muv, sa62/+ variable Muv, 5-50%) Cloned: 4.9 kb transcript, encodes 1323 aa EGF-receptor class tyrosine kinase (pka kin-7);let23:lacZ expressed in many but not all cells.Extensive molecular and developmental analysis.See also lfe, sli, etc. [Sigurdson et al. 1984; Aroian et al. 1990; Aroian and Sternberg 1991; Aroian et al. 1994; Koga and Ohshima 1995; FK; SP]
    Complementation_data: [Edgley ML] Fails to complement let-23(mn23)
    Strain (21)
    Component_of_genotype: WBGenotype00000109
      WBGenotype00000110
      WBGenotype00000111
      WBGenotype00000112
      WBGenotype00000113
      WBGenotype00000114
    RNASeq_FPKM (74)
    GO_annotation (51)
    Ortholog (57)
    Paralog (33)
    Structured_description: Concise_description: let-23 encodes an EGF-receptor-family transmembrane tyrosine kinase that affects viability, inductive signaling during development of the vulva, male spicule formation, posterior development of the epidermis, ovulation and stress induced sleep; let-23 is genetically upstream of the let-60/RAS pathway with respect to viability and vulval development, is upstream of phosopholipase C gamma with respect to fertility and sleep, and is expressed in vulval precursor cells and the ALA neuron. Paper_evidence: WBPaper00045813
          Person_evidence: WBPerson625
          Curator_confirmed: WBPerson324
            WBPerson567
          Date_last_updated: 28 May 2015 00:00:00
      Automated_description: Enables epidermal growth factor receptor activity. Involved in several processes, including determination of adult lifespan; positive regulation of vulval development; and reproductive structure development. Located in cell-cell junction and plasma membrane. Expressed in several structures, including apoptotic cell; egg-laying apparatus; excretory duct cell; head; and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Is an ortholog of human EGFR (epidermal growth factor receptor) and ERBB4 (erb-b2 receptor tyrosine kinase 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (48)
  Molecular_info: Corresponding_CDS: ZK1067.1a
      ZK1067.1b
      ZK1067.1c
      ZK1067.1d
    Corresponding_CDS_history: ZK1067.1:wp110
    Corresponding_transcript: ZK1067.1a.1
      ZK1067.1b.1
      ZK1067.1c.1
      ZK1067.1d.1
    Other_sequence: X57767
      CR07463
      JI229755.1
      JI164844.1
      MHC11568_1
      MH06032
      ACC08710_1
      EX550763.1
      CRC12189_1
    Associated_feature: WBsf644553
      WBsf717766
      WBsf988979
      WBsf988980
      WBsf988981
      WBsf988982
      WBsf1012824
      WBsf1012825
      WBsf221857
  Experimental_info: RNAi_result: WBRNAi00086137 Inferred_automatically: RNAi_primary
      WBRNAi00084770 Inferred_automatically: RNAi_primary
      WBRNAi00111705 Inferred_automatically: RNAi_primary
      WBRNAi00069418 Inferred_automatically: RNAi_primary
      WBRNAi00021795 Inferred_automatically: RNAi_primary
      WBRNAi00110660 Inferred_automatically: RNAi_primary
      WBRNAi00059089 Inferred_automatically: RNAi_primary
      WBRNAi00078911 Inferred_automatically: RNAi_primary
      WBRNAi00078912 Inferred_automatically: RNAi_primary
    Expr_pattern (18)
    Drives_construct (18)
    Construct_product (15)
    Antibody: WBAntibody00000229
      WBAntibody00000972
      WBAntibody00001216
    Microarray_results (23)
    Expression_cluster (140)
    Interaction (645)
    WBProcess: WBbiopr:00000020
      WBbiopr:00000044
      WBbiopr:00000067
      WBbiopr:00000070
      WBbiopr:00000071
  Map_info: Map: II Position: 1.09455 Error: 0.000258
    Well_ordered
    Positive: Inside_rearr: mnDf61
        mnDf62
        mnDf67
        mnDf69
      Positive_clone: T08E2
        ZK1067 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: mDf17
    Mapping_data: 2_point: 5725
      Multi_point: 828
        2070
        3120
        3220
        3221
        3222
        3347
        3533
        4007
      Pos_neg_data (22)
    Landmark_gene
  Reference (503)
  Method: Gene