WormBase Tree Display for Gene: WBGene00004034
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| WBGene00004034 | SMap | S_parent | Sequence | F09E5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pkc-3 | Person_evidence | WBPerson1505 | |||||
| Sequence_name | F09E5.1 | ||||||||
| Molecular_name | F09E5.1 | ||||||||
| F09E5.1.1 | |||||||||
| CE02604 | |||||||||
| Other_name | CELE_F09E5.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | pkc-3 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pkc | ||||||||
| Allele (65) | |||||||||
| Possibly_affected_by | WBVar02152812 | ||||||||
| WBVar02152813 | |||||||||
| WBVar02152814 | |||||||||
| WBVar02152815 | |||||||||
| WBVar02157824 | |||||||||
| Strain | WBStrain00023583 | ||||||||
| WBStrain00035639 | |||||||||
| WBStrain00040444 | |||||||||
| WBStrain00024328 | |||||||||
| WBStrain00024217 | |||||||||
| WBStrain00054960 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (57) | |||||||||
| Contained_in_operon | CEOP2172 | ||||||||
| CEOP2745 | |||||||||
| Ortholog (45) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | pkc-3 encodes an atypical protein kinase that lacks a DAG binding domain; during early embryonic development, pkc-3 plays an essential role in establishing anterior-posterior polarity; PKC-3 localizes to the anterior periphery of the one-cell embryo in a manner dependent upon the PAR-3 PDZ domain-containing protein with which PKC-3 physically interacts; PKC-3 also localizes to the outer, apical surfaces of cells. | Paper_evidence | WBPaper00002989 | |||||
| WBPaper00003228 | |||||||||
| WBPaper00003233 | |||||||||
| WBPaper00006199 | |||||||||
| WBPaper00033094 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 07 Jun 2013 00:00:00 | ||||||||
| Automated_description | Enables protein domain specific binding activity and protein serine/threonine kinase activity. Involved in several processes, including antifungal innate immune response; gonad development; and response to wounding. Located in apical plasma membrane; cortical actin cytoskeleton; and cytosol. Expressed in several structures, including Psub4; enteric muscle; hypodermis; pharyngeal-intestinal valve; and vulva. Human ortholog(s) of this gene implicated in invasive ductal carcinoma and ovarian carcinoma. Is an ortholog of human PRKCI (protein kinase C iota) and PRKCZ (protein kinase C zeta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3008 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9404) | ||||
| DOID:4001 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9404) | ||||||
| Molecular_info | Corresponding_CDS | F09E5.1 | |||||||
| Corresponding_transcript | F09E5.1.1 | ||||||||
| Other_sequence (41) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (25) | ||||||||
| Expr_pattern | Expr1287 | ||||||||
| Expr1449 | |||||||||
| Expr14960 | |||||||||
| Expr14961 | |||||||||
| Expr1016101 | |||||||||
| Expr1031936 | |||||||||
| Expr1148086 | |||||||||
| Expr2014946 | |||||||||
| Expr2033181 | |||||||||
| Drives_construct | WBCnstr00035731 | ||||||||
| WBCnstr00041820 | |||||||||
| Construct_product | WBCnstr00020466 | ||||||||
| WBCnstr00035731 | |||||||||
| WBCnstr00041368 | |||||||||
| Antibody | WBAntibody00000160 | ||||||||
| WBAntibody00000194 | |||||||||
| WBAntibody00000450 | |||||||||
| WBAntibody00000902 | |||||||||
| WBAntibody00001140 | |||||||||
| WBAntibody00001421 | |||||||||
| WBAntibody00001422 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (113) | |||||||||
| Interaction (137) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | II | Position | -1.78543 | Error | 0.000235 | |||
| Positive | Positive_clone | F09E5 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4588 | |||||||
| Pseudo_map_position | |||||||||
| Reference (132) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
