WormBase Tree Display for Gene: WBGene00006752
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| WBGene00006752 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-13 | Person_evidence | WBPerson261 | |||||
| Sequence_name | ZK524.2 | ||||||||
| Molecular_name (33) | |||||||||
| Other_name | CELE_ZK524.2 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | unc-13 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00142935 | ||||||||
| Allele (364) | |||||||||
| Possibly_affected_by | WBVar00090573 | ||||||||
| Legacy_information | e51 : paralysed kinky small irregular pharyngeal pumping able to lay eggs. ES3 ME0. NA > 30 (e450amber e312amber (non-null) e309 (see sup- 6) etc.; all similar to e51 or slightly weaker). | ||||||||
| See also e51, e328, e450, e973, e985, e2208, e2274 | |||||||||
| [C.elegansII] e51 : paralysed, kinky, small, irregular pharyngeal pumping; able to lay eggs. Ric, high acetylcholine levels; variable neuroanatomical defects.ES3 ME0. OA>30: e450amb, e312amb (non-null),e309 (suppressed by sup-6), s69, s178 etc. All alleles similar to e51 or slightly weaker. Cloned: very large gene, encodes 1734 aa novel protein with contains phorbol ester (diacylglycerol) binding site. Antibodies detect 190 kD UNC-13. [Brenner 1974; Ahmed et al. 1992; Nguyen et al. 1995] | |||||||||
| Strain (312) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (39) | |||||||||
| Ortholog (53) | |||||||||
| Structured_description | Concise_description | unc-13 encodes at least five protein isoforms that regulate neurotransmitter release by altering the conformation of syntaxin; UNC-13 proteins are required for normal pharyngeal pumping and thrashing in liquid, normally short lifespan, normally large brood sizes, and full adult body sizes; UNC-13 proteins have orthologs in vertebrates and Drosophila; UNC-13 proteins are complex, with multiple C2, phorbol ester-binding, and DUF1041 domains; UNC-13 protein form is localized to most or all synapses; many of the unc-13 mutant alleles with viable phenotypes are transcript-specific, while homozygotes with an unc-13 null (deletion) allele die as paralyzed first-stage larvae. | Paper_evidence | WBPaper00004372 | |||||
| WBPaper00005528 | |||||||||
| WBPaper00005729 | |||||||||
| WBPaper00005799 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable calmodulin binding activity and syntaxin-1 binding activity. Involved in regulation of multicellular organismal process; spermatogenesis; and synaptic vesicle exocytosis. Located in presynaptic active zone. Expressed in head neurons; neurons; tail neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Is an ortholog of human UNC13C (unc-13 homolog C). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:332 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23150) | ||||
| Molecular_info | Corresponding_CDS (11) | ||||||||
| Corresponding_CDS_history | ZK524.2b:wp92 | ||||||||
| ZK524.2b:wp105 | |||||||||
| ZK524.2b:wp144 | |||||||||
| ZK524.2c:wp105 | |||||||||
| ZK524.2d:wp105 | |||||||||
| Corresponding_transcript (11) | |||||||||
| Other_sequence (79) | |||||||||
| Associated_feature (35) | |||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00000946 | ||||||||
| WBCnstr00000947 | |||||||||
| WBCnstr00001317 | |||||||||
| WBCnstr00001318 | |||||||||
| WBCnstr00001321 | |||||||||
| WBCnstr00001368 | |||||||||
| WBCnstr00001634 | |||||||||
| WBCnstr00003103 | |||||||||
| WBCnstr00006491 | |||||||||
| WBCnstr00017861 | |||||||||
| Construct_product (13) | |||||||||
| Antibody | WBAntibody00000321 | ||||||||
| WBAntibody00001084 | |||||||||
| WBAntibody00001499 | |||||||||
| Microarray_results (41) | |||||||||
| Expression_cluster (215) | |||||||||
| Interaction (134) | |||||||||
| Map_info | Map | I | Position | 2.07486 | Error | 0.004126 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | gaDp1 | |||||||
| nDf26 | |||||||||
| nDp4 | |||||||||
| sDf5 | |||||||||
| sDf6 | |||||||||
| Positive_clone | C44E1 | ||||||||
| ZK524 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Outside_rearr | qDf16 | |||||||
| nDp1 | |||||||||
| Mapping_data | 2_point (39) | ||||||||
| Multi_point (234) | |||||||||
| Pos_neg_data (72) | |||||||||
| Landmark_gene | |||||||||
| Reference (405) | |||||||||
| Remark | yk16b7.3 removed from sequence list. sdm 11/00 | ||||||||
| Method | Gene |
