WormBase Tree Display for Gene: WBGene00006784
expand all nodes | collapse all nodes | view schema
WBGene00006784 | Evidence | CGC_data_submission | ||||
---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T21C12 | |||
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | unc | |||||
Reference_allele | WBVar00143164 | |||||
Allele (220) | ||||||
Legacy_information | e382 : shrinker contracts both dorsally and ventrally when prodded slow poor backing slightly small. ES3 ME2. NA6 (e407 e468). | |||||
See also e641, n1324 | ||||||
[C.elegansII] e382 : shrinker, contracts both dorsally and ventrally when prodded; slow; poor backing, slightly small. Probable defect in inhibitory GABA receptor function. ES3 ME2. OA>5: e407, e468, e929, n1324 etc. Cloned: encodes predicted GABA-A receptor. In probable operon with two other GABA receptor subunits. [Brenner 1974; McIntire et al. 1993; EG; MT] | ||||||
Strain (14) | ||||||
Component_of_genotype | WBGenotype00000119 | |||||
RNASeq_FPKM (74) | ||||||
GO_annotation (28) | ||||||
Ortholog (37) | ||||||
Paralog (100) | ||||||
Structured_description | Concise_description | unc-49 encodes multiple subunits of a heteromeric GABA receptor; unc-49 activity is required for postsynaptic GABA responsiveness and thus for normal regulation of locomotion; UNC-49::GFP reporter fusions for at least two isoforms are expressed in dorsal and ventral head and body wall muscles, with isoform-specific expression also seen in the sphincter muscle; UNC-49::GFP subcellular localization is most prominent at neuromuscular junctions; in Xenopus oocytes and mammalian tissue culture cells, two UNC-49 subunits, UNC-49B and UNC-49C, are able to form a functional heteromeric GABA receptor. | Paper_evidence | WBPaper00003576 | ||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 24 Aug 2007 00:00:00 | |||||
Automated_description | Predicted to enable transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to chloride channel activity. Involved in gamma-aminobutyric acid signaling pathway; locomotory behavior; and regulation of backward locomotion. Located in neuromuscular junction and postsynaptic membrane. Expressed in AVA; anal sphincter muscle; body wall musculature; and somatic nervous system. Used to study epilepsy. | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00060194 | |
Curator_confirmed | WBPerson324 | |||||
Date_last_updated | 18 May 2022 00:00:00 | |||||
Models_disease_asserted | WBDOannot00001202 | |||||
WBDOannot00001203 | ||||||
Molecular_info | Corresponding_CDS (13) | |||||
Corresponding_CDS_history | T21C12.1a:wp227 | |||||
T21C12.1a:wp239 | ||||||
T21C12.1g:wp275 | ||||||
Corresponding_transcript (14) | ||||||
Other_sequence (51) | ||||||
Associated_feature (25) | ||||||
Experimental_info | RNAi_result | WBRNAi00090257 | Inferred_automatically | RNAi_primary | ||
WBRNAi00053708 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00089728 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00066348 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00027895 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00000954 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00090099 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00018961 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00089939 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00006214 | Inferred_automatically | RNAi_primary | ||||
Expr_pattern | Expr1283 | |||||
Expr15907 | ||||||
Expr1027570 | ||||||
Expr1032855 | ||||||
Expr1157259 | ||||||
Expr1200291 | ||||||
Expr2017881 | ||||||
Expr2036017 | ||||||
Marker2 | ||||||
Marker19 | ||||||
Drives_construct | WBCnstr00001626 | |||||
WBCnstr00001627 | ||||||
WBCnstr00006881 | ||||||
WBCnstr00010191 | ||||||
WBCnstr00019381 | ||||||
WBCnstr00020581 | ||||||
WBCnstr00034153 | ||||||
WBCnstr00042588 | ||||||
Construct_product | WBCnstr00001627 | |||||
WBCnstr00006881 | ||||||
WBCnstr00016180 | ||||||
WBCnstr00019381 | ||||||
WBCnstr00020010 | ||||||
WBCnstr00020581 | ||||||
WBCnstr00021428 | ||||||
WBCnstr00034153 | ||||||
Antibody | WBAntibody00000613 | |||||
WBAntibody00001987 | ||||||
Microarray_results (88) | ||||||
Expression_cluster (187) | ||||||
Interaction (31) | ||||||
WBProcess | WBbiopr:00000010 | |||||
Map_info (4) | ||||||
Reference (138) | ||||||
Remark | Sequence connection from [Bamber BA] | |||||
Method | Gene |