WormBase Tree Display for Gene: WBGene00006809
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WBGene00006809 | SMap | S_parent | Sequence | C11D2 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | unc-77 | Person_evidence | WBPerson261 | |||
Sequence_name | C11D2.6 | ||||||
Molecular_name (48) | |||||||
Other_name | nca-1 | Paper_evidence | WBPaper00031592 | ||||
Person_evidence | WBPerson604 | ||||||
CELE_C11D2.6 | Accession_evidence | NDB | BX284604 | ||||
Public_name | unc-77 | ||||||
DB_info | Database | WormQTL | gene | WBGene00006809 | |||
WormFlux | gene | WBGene00006809 | |||||
NDB | locus_tag | CELE_C11D2.6 | |||||
Panther | gene | CAEEL|WormBase=WBGene00006809|UniProtKB=V6CKM5 | |||||
family | PTHR46141 | ||||||
NCBI | gene | 177379 | |||||
RefSeq | protein (16) | ||||||
TREEFAM | TREEFAM_ID | TF312843 | |||||
TrEMBL | UniProtAcc (16) | ||||||
UniProt_GCRP | UniProtAcc | V6CKM5 | |||||
OMIM | gene | 611549 | |||||
Species | Caenorhabditis elegans | ||||||
History (2) | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143348 | ||||||
Allele (298) | |||||||
Legacy_information | e625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1. | ||||||
[C.elegansII] e625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1. [Brenner 1974] | |||||||
Strain | WBStrain00035028 | ||||||
WBStrain00035029 | |||||||
WBStrain00035482 | |||||||
WBStrain00040855 | |||||||
WBStrain00040862 | |||||||
WBStrain00040863 | |||||||
WBStrain00040864 | |||||||
WBStrain00040865 | |||||||
WBStrain00006352 | |||||||
Component_of_genotype | WBGenotype00000089 | ||||||
WBGenotype00000090 | |||||||
WBGenotype00000091 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (18) | |||||||
Ortholog (51) | |||||||
Paralog | WBGene00003558 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | |||||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00000367 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00001187 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00006742 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00008911 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | unc-77 encodes, along with nca-2, one of two C. elegans alpha-1-like subunits of a voltage-insensitive cation leak channel related to Drosophila narrow abdomen and the vertebrate Vgcnl1/NALCN proteins; unc-77 functions redundantly with nca-2 to transmit depolarization signals from neuronal cell bodies to axons, thus regulating presynaptic activation; unc-77 and nca-2 are also required for normal locomotion and the response to specific volatile anesthetics; in regulating synaptic activity, unc-77 appears to function in the same pathway as unc-79 and unc-80, which encode novel conserved proteins that reciprocally regulate UNC-77 expression; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-77::gfp reporter fusion is expressed in many sensory and all motoneurons; in the dorsal and ventral nerve cords, UNC-77 localizes to specific axonal regions, but not to synapses. | Paper_evidence | WBPaper00030757 | |||
WBPaper00031000 | |||||||
WBPaper00031592 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 22 Jun 2010 00:00:00 | ||||||
Automated_description | Enables monoatomic cation channel activity. Involved in positive regulation of GABAergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and positive regulation of locomotion. Located in axon. Expressed in cholinergic neurons; nerve ring; pharyngeal neurons; and tail ganglion. Used to study congenital limbs-face contractures-hypotonia-developmental delay syndrome. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Is an ortholog of human NALCN (sodium leak channel, non-selective). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:0081048 | Homo sapiens | Paper_evidence | WBPaper00046648 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 09 Feb 2022 00:00:00 | ||||||
Potential_model | EFO:MONDO:0014176 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19082) | |||
DOID:0081048 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19082) | ||||
Models_disease_asserted | WBDOannot00001101 | ||||||
WBDOannot00001105 | |||||||
Molecular_info | Corresponding_CDS (16) | ||||||
Corresponding_CDS_history | C11D2.6a:wp239 | ||||||
C11D2.6b:wp239 | |||||||
C11D2.6c:wp239 | |||||||
Corresponding_transcript (16) | |||||||
Other_sequence (15) | |||||||
Associated_feature | WBsf651837 | ||||||
WBsf996705 | |||||||
WBsf996706 | |||||||
WBsf996707 | |||||||
WBsf996708 | |||||||
WBsf996709 | |||||||
WBsf1017492 | |||||||
WBsf1017493 | |||||||
WBsf230141 | |||||||
WBsf230142 | |||||||
Experimental_info | RNAi_result (15) | ||||||
Expr_pattern | Chronogram197 | ||||||
Expr4860 | |||||||
Expr5240 | |||||||
Expr8058 | |||||||
Expr8060 | |||||||
Expr8194 | |||||||
Expr8324 | |||||||
Expr1144413 | |||||||
Expr2017906 | |||||||
Expr2036042 | |||||||
Drives_construct (12) | |||||||
Construct_product (8) | |||||||
Antibody | WBAntibody00001260 | ||||||
WBAntibody00001384 | |||||||
Microarray_results (48) | |||||||
Expression_cluster (190) | |||||||
Interaction (21) | |||||||
Map_info | Map | IV | Position | 3.08555 | |||
Positive | Positive_clone | C11D2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | 2_point | 323 | |||||
Multi_point | 1422 | ||||||
4509 | |||||||
Reference (42) | |||||||
Method | Gene |