WormBase Tree Display for Gene: WBGene00003136
expand all nodes | collapse all nodes | view schema
| WBGene00003136 | SMap | S_parent | Sequence | C09H6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mau-2 | Person_evidence | WBPerson247 | |||||
| Sequence_name | C09H6.3 | ||||||||
| Molecular_name | C09H6.3 | ||||||||
| C09H6.3.1 | |||||||||
| CE15611 | |||||||||
| Other_name | CELE_C09H6.3 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | mau-2 | ||||||||
| DB_info | Database | AceView | gene | 1I705 | |||||
| WormQTL | gene | WBGene00003136 | |||||||
| WormFlux | gene | WBGene00003136 | |||||||
| NDB | locus_tag | CELE_C09H6.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003136|UniProtKB=O17581 | |||||||
| family | PTHR21394 | ||||||||
| NCBI | gene | 172598 | |||||||
| RefSeq | protein | NM_059827.7 | |||||||
| SwissProt | UniProtAcc | O17581 | |||||||
| TREEFAM | TREEFAM_ID | TF105981 | |||||||
| UniProt_GCRP | UniProtAcc | O17581 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 15 Feb 2005 15:39:39 | WBPerson2970 | Event | Acquires_merge | WBGene00007498 | ||||
| Acquires_merge | WBGene00007498 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mau | ||||||||
| Allele (96) | |||||||||
| Legacy_information | [Hekimi S] kinky Unc, Egl, neuroanatomical defects; short excretory canals; Egl; some lethality; full zygotic rescue, almost complete maternal rescue, no maternal rescue of Egl. OA2 (qm5, qm40). [MQ] | ||||||||
| [C.elegansII] qm4 : kinky Unc, Egl, neuroanatomical defects; short excretory canals; Egl; some lethality; full zygotic rescue, almost complete maternal rescue, no maternal rescue of Egl. OA2 (qm5, qm40). [MQ] | |||||||||
| Strain | WBStrain00026635 | ||||||||
| WBStrain00026668 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | mau-2 encodes an ortholog of budding yeast Scc4p, Drosophila CG4203, andhuman KIAA0892; MAU-2 is required (with PQN-85 and SCC-3) for normalmitotic chromosome segregation, and for cellular (e.g., neuronal) oraxonal migration; MAU-2 is required for migration both embryonically andpostembryonically, along both dorsoventral and longitudinal body axes;MAU-2 guides the axonal projection of AVM (and probably other neurons)by some cell-autonomous mechanism independent of SLT-1; MAU-2 is alsorequired for normal larval development, locomotion, excretory canals andosmoregulation, phasmid morphology, and egg-laying; the primarysequences of MAU-2 and its Scc4-like orthologs are composed oftetratricopeptide repeats, and are highly divergent between yeast andmetazoa; MAU-2 is expressed ubiquitously in embryos during lategastrulation, subsequently becoming restricted to neurons; mau-2transcripts are abundant in oocytes, and maternal transcripts alone cansupport normal MAU-2 protein synthesis through the L3 larval stage (butnot in L4 larvae or adults); MAU-2's N-terminal 371 residues of MAU-2are its most conserved domain, and are sufficient to transgenicallyrescue mau-2 mutants; despite its behavioral phenotype, MAU-2 is thoughtto act early in development, since the uncoordinated phenotype of mau-2mutants is maternal; while the uncoordinated phenotype of mau-2 mutantscan be rescued either maternally or zygotically, the egg-layingphenotype of mau-2 mutants is purely zygotic; partially penetrant mau-2dye-filling phenotypes occur on one side of the body, suggesting thatMAU-2 acts on a whole side of an embryo at a time; while mau-2(RNAi) hasno obvious early embryonic phenotype, joint mau-2/scc-3(RNAi) grosslyderanges chromosomal segregation in early embryos, and mau-2(RNAi)enhances the lagging of anaphase chromosomes induced by pqn-85(RNAi). | Paper_evidence | WBPaper00002340 | |||||
| WBPaper00002968 | |||||||||
| WBPaper00024594 | |||||||||
| WBPaper00027710 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 24 Apr 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable double-stranded DNA binding activity. Involved in anterior/posterior axon guidance; dorsal/ventral axon guidance; and egg-laying behavior. Located in axon and cytoplasm. Expressed in nervous system; oocyte; and vulval muscle. Is an ortholog of human MAU2 (MAU2 sister chromatid cohesion factor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C09H6.3 | |||||||
| Corresponding_transcript | C09H6.3.1 | ||||||||
| Other_sequence | CR00998 | ||||||||
| CJC10824_1 | |||||||||
| ES741290.1 | |||||||||
| CRC03374_1 | |||||||||
| HBC21988_1 | |||||||||
| CBC17050_1 | |||||||||
| Associated_feature | WBsf643511 | ||||||||
| WBsf656608 | |||||||||
| WBsf984349 | |||||||||
| WBsf984350 | |||||||||
| WBsf218122 | |||||||||
| WBsf218123 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00028762 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00040272 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065886 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065882 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065885 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061479 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00002926 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116844 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3158 | ||||||||
| Expr3159 | |||||||||
| Expr3160 | |||||||||
| Expr1015173 | |||||||||
| Expr1031480 | |||||||||
| Expr1144341 | |||||||||
| Expr2013425 | |||||||||
| Expr2031659 | |||||||||
| Drives_construct | WBCnstr00036220 | ||||||||
| Construct_product | WBCnstr00036220 | ||||||||
| Antibody | WBAntibody00000827 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (110) | |||||||||
| Interaction | WBInteraction000005105 | ||||||||
| WBInteraction000238851 | |||||||||
| WBInteraction000280639 | |||||||||
| WBInteraction000295169 | |||||||||
| WBInteraction000319522 | |||||||||
| WBInteraction000324440 | |||||||||
| WBInteraction000325103 | |||||||||
| WBInteraction000330055 | |||||||||
| WBInteraction000345545 | |||||||||
| WBInteraction000389578 | |||||||||
| WBInteraction000393532 | |||||||||
| WBInteraction000397944 | |||||||||
| WBInteraction000398862 | |||||||||
| WBInteraction000401350 | |||||||||
| WBInteraction000402937 | |||||||||
| WBInteraction000405297 | |||||||||
| WBInteraction000405377 | |||||||||
| WBInteraction000409524 | |||||||||
| WBInteraction000416391 | |||||||||
| WBInteraction000416740 | |||||||||
| WBInteraction000418154 | |||||||||
| WBInteraction000424008 | |||||||||
| WBInteraction000425350 | |||||||||
| WBInteraction000427516 | |||||||||
| WBInteraction000428411 | |||||||||
| WBInteraction000430421 | |||||||||
| WBInteraction000430979 | |||||||||
| WBInteraction000432749 | |||||||||
| WBInteraction000438652 | |||||||||
| WBInteraction000443004 | |||||||||
| WBInteraction000450348 | |||||||||
| WBInteraction000452903 | |||||||||
| WBInteraction000455617 | |||||||||
| WBInteraction000455633 | |||||||||
| WBInteraction000567227 | |||||||||
| WBInteraction000567817 | |||||||||
| WBInteraction000573470 | |||||||||
| Map_info | Map | I | Position | 2.56119 | Error | 0.005309 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf24 | |||||||
| Positive_clone | C09H6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | nDf23 | |||||||
| Mapping_data | Multi_point | 3610 | |||||||
| Pos_neg_data | 9306 | ||||||||
| 9307 | |||||||||
| Reference (18) | |||||||||
| Method | Gene |
