WormBase Tree Display for Gene: WBGene00004078

WBGene00004078 SMap: S_parent: Sequence: F52E1
  Identity: Version: 1
    Name: CGC_name: pos-1 Person_evidence: WBPerson419
      Sequence_name: F52E1.1
      Molecular_name: F52E1.1
        F52E1.1.1
        CE04629
      Other_name: CELE_F52E1.1 Accession_evidence: NDB BX284605
      Public_name: pos-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pos
    Allele (25)
    Legacy_information: [Tabara H] Terminal stage pos-1 mutant embryos lack germ cell progenitors and intestine. ABp also produces pharynx. Maternal mRNA of pos-1 localizes into P-lineage.
    Strain: WBStrain00022471
      WBStrain00005744
      WBStrain00030276
      WBStrain00022478
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (47)
    Paralog (20)
    Structured_description: Concise_description: pos-1 encodes a CCCH-type zinc-finger protein; during embryogenesis, maternally provided POS-1 is essential for proper fate specification of germ cells, intestine, pharynx, and hypodermis; POS-1's role in cell fate specification is likely as a translational regulator, as POS-1 is required, in posterior blastomeres, for positive regulation of apx-1 mRNA translation and negative regulation of glp-1 mRNA translation via direct binding to the spatial control region (SCR) in the glp-1 mRNA 3' UTR; in regulating mRNA translation, POS-1 interacts with SPN-4, an RNP-type RNA binding protein, that may function to negatively regulate POS-1 activity; POS-1 can also bind the mex-6 3'-UTR in vitro, although expression of a MEX-6 reporter fusion protein does not appear to be affected in pos-1 mutant animals; pos-1 mRNA is first detected in the gonads of L4 and adult animals, and is present uniformly in oocytes and newly fertilized embryos; during early embryonic divisions, pos-1 mRNA is present at higher levels in germline blastomeres until it disappears following the division of P4; POS-1 protein is first apparent at low levels in 1-cell embryos, with subsequent expression mirroring that of pos-1 mRNA: high levels in germline blastomeres until its disappearance after the P4 division; in the germline blastomeres P1, P2, P3, and P4, POS-1 colocalizes with cytoplasmic and perinuclear P granules. Paper_evidence: WBPaper00003382
            WBPaper00005822
            WBPaper00028569
          Curator_confirmed: WBPerson1843
          Date_last_updated: 09 Feb 2012 00:00:00
      Automated_description: Enables mRNA 3'-UTR binding activity; poly(U) RNA binding activity; and transcription corepressor activity. Involved in several processes, including cell fate specification; embryonic pattern specification; and negative regulation of transcription by RNA polymerase II. Located in P granule. Expressed in several structures, including Psub4; germ line; neurons; oocyte; and rectal gland cell. Human ortholog(s) of this gene implicated in breast cancer. Is an ortholog of human ZFP36 (ZFP36 ring finger protein); ZFP36L1 (ZFP36 ring finger protein like 1); and ZFP36L2 (ZFP36 ring finger protein like 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12862)
      EFO:MONDO:0014769 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1108)
  Molecular_info: Corresponding_CDS: F52E1.1
    Corresponding_transcript: F52E1.1.1
    Other_sequence (43)
    Associated_feature: WBsf977478
      WBsf977479
      WBsf977480
      WBsf978729
      WBsf232104
      WBsf232105
    Gene_product_binds: WBsf028078
      WBsf034245
    Transcription_factor: WBTranscriptionFactor000111
  Experimental_info: RNAi_result (46)
    Expr_pattern (14)
    Drives_construct: WBCnstr00012723
      WBCnstr00017949
      WBCnstr00040853
      WBCnstr00042916
    Construct_product: WBCnstr00000085
      WBCnstr00005587
      WBCnstr00016851
      WBCnstr00017949
      WBCnstr00021253
      WBCnstr00022630
    Antibody (7)
    Microarray_results (22)
    Expression_cluster (255)
    Interaction: WBInteraction000002071
      WBInteraction000002138
      WBInteraction000003210
      WBInteraction000003700
      WBInteraction000003701
      WBInteraction000003746
      WBInteraction000003747
      WBInteraction000006492
      WBInteraction000006551
      WBInteraction000006595
      WBInteraction000006605
      WBInteraction000006996
      WBInteraction000009721
      WBInteraction000009725
      WBInteraction000009730
      WBInteraction000028253
      WBInteraction000050866
      WBInteraction000050867
      WBInteraction000050868
      WBInteraction000050885
      WBInteraction000050886
      WBInteraction000050887
      WBInteraction000050888
      WBInteraction000050889
      WBInteraction000050890
      WBInteraction000050891
      WBInteraction000052661
      WBInteraction000052662
      WBInteraction000102570
      WBInteraction000104238
      WBInteraction000104516
      WBInteraction000104699
      WBInteraction000105223
      WBInteraction000106375
      WBInteraction000109605
      WBInteraction000112618
      WBInteraction000112902
      WBInteraction000114350
      WBInteraction000115035
      WBInteraction000115496
      WBInteraction000115632
      WBInteraction000115731
      WBInteraction000115801
      WBInteraction000118167
      WBInteraction000120461
      WBInteraction000122383
      WBInteraction000125905
      WBInteraction000126845
      WBInteraction000126984
      WBInteraction000133318
      WBInteraction000136085
      WBInteraction000139348
      WBInteraction000140142
      WBInteraction000141588
      WBInteraction000144037
      WBInteraction000146761
      WBInteraction000147268
      WBInteraction000147971
      WBInteraction000148258
      WBInteraction000148281
      WBInteraction000151096
      WBInteraction000160090
      WBInteraction000160368
      WBInteraction000161943
      WBInteraction000165212
      WBInteraction000165829
      WBInteraction000166184
      WBInteraction000166185
      WBInteraction000167985
      WBInteraction000168324
      WBInteraction000168711
      WBInteraction000170377
      WBInteraction000170627
      WBInteraction000170765
      WBInteraction000171624
      WBInteraction000172086
      WBInteraction000174703
      WBInteraction000174763
      WBInteraction000177318
      WBInteraction000177343
      WBInteraction000177499
      WBInteraction000178478
      WBInteraction000178573
      WBInteraction000178821
      WBInteraction000179298
      WBInteraction000179903
      WBInteraction000180046
      WBInteraction000180221
      WBInteraction000188711
      WBInteraction000190699
      WBInteraction000191639
      WBInteraction000193957
      WBInteraction000194937
      WBInteraction000195299
      WBInteraction000196156
      WBInteraction000198140
      WBInteraction000199412
      WBInteraction000201081
      WBInteraction000202686
      WBInteraction000208306
      WBInteraction000208313
      WBInteraction000213998
      WBInteraction000214283
      WBInteraction000214993
      WBInteraction000217860
      WBInteraction000219302
      WBInteraction000219686
      WBInteraction000220457
      WBInteraction000221909
      WBInteraction000223106
      WBInteraction000224814
      WBInteraction000225699
      WBInteraction000227313
      WBInteraction000227513
      WBInteraction000228385
      WBInteraction000229224
      WBInteraction000230009
      WBInteraction000232439
      WBInteraction000232817
      WBInteraction000234589
      WBInteraction000234940
      WBInteraction000234943
      WBInteraction000236010
      WBInteraction000236654
      WBInteraction000237232
      WBInteraction000237653
      WBInteraction000240087
      WBInteraction000244180
      WBInteraction000245105
      WBInteraction000245490
      WBInteraction000249335
      WBInteraction000249483
      WBInteraction000250986
      WBInteraction000255104
      WBInteraction000255319
      WBInteraction000255943
      WBInteraction000258150
      WBInteraction000258200
      WBInteraction000258884
      WBInteraction000263204
      WBInteraction000266247
      WBInteraction000266349
      WBInteraction000267707
      WBInteraction000268053
      WBInteraction000268251
      WBInteraction000269948
      WBInteraction000270213
      WBInteraction000272063
      WBInteraction000274766
      WBInteraction000275630
      WBInteraction000276062
      WBInteraction000276229
      WBInteraction000277892
      WBInteraction000279646
      WBInteraction000280041
      WBInteraction000280865
      WBInteraction000281235
      WBInteraction000283606
      WBInteraction000283640
      WBInteraction000284129
      WBInteraction000286281
      WBInteraction000288001
      WBInteraction000289422
      WBInteraction000289449
      WBInteraction000290072
      WBInteraction000291038
      WBInteraction000291338
      WBInteraction000291588
      WBInteraction000296633
      WBInteraction000297628
      WBInteraction000298901
      WBInteraction000308539
      WBInteraction000308601
      WBInteraction000313752
      WBInteraction000316014
      WBInteraction000316788
      WBInteraction000317443
      WBInteraction000318318
      WBInteraction000320807
      WBInteraction000322281
      WBInteraction000322673
      WBInteraction000322704
      WBInteraction000323438
      WBInteraction000324732
      WBInteraction000329855
      WBInteraction000330903
      WBInteraction000332964
      WBInteraction000333473
      WBInteraction000340176
      WBInteraction000340878
      WBInteraction000341267
      WBInteraction000341391
      WBInteraction000341448
      WBInteraction000342489
      WBInteraction000344090
      WBInteraction000347480
      WBInteraction000348976
      WBInteraction000355339
      WBInteraction000359073
      WBInteraction000359238
      WBInteraction000360806
      WBInteraction000367142
      WBInteraction000367924
      WBInteraction000369339
      WBInteraction000370905
      WBInteraction000370936
      WBInteraction000371759
      WBInteraction000372286
      WBInteraction000372519
      WBInteraction000373011
      WBInteraction000373767
      WBInteraction000373846
      WBInteraction000377975
      WBInteraction000378766
      WBInteraction000378894
      WBInteraction000380113
      WBInteraction000380795
      WBInteraction000380917
      WBInteraction000382257
      WBInteraction000392842
      WBInteraction000393037
      WBInteraction000394451
      WBInteraction000395172
      WBInteraction000397405
      WBInteraction000398341
      WBInteraction000399539
      WBInteraction000399825
      WBInteraction000401354
      WBInteraction000412432
      WBInteraction000414428
      WBInteraction000416719
      WBInteraction000417140
      WBInteraction000418780
      WBInteraction000420040
      WBInteraction000420338
      WBInteraction000420466
      WBInteraction000420956
      WBInteraction000421722
      WBInteraction000423969
      WBInteraction000427749
      WBInteraction000427832
      WBInteraction000428594
      WBInteraction000429462
      WBInteraction000431163
      WBInteraction000431967
      WBInteraction000433979
      WBInteraction000438679
      WBInteraction000438916
      WBInteraction000439801
      WBInteraction000440651
      WBInteraction000442595
      WBInteraction000443825
      WBInteraction000445480
      WBInteraction000445677
      WBInteraction000451214
      WBInteraction000451745
      WBInteraction000458010
      WBInteraction000459996
      WBInteraction000469720
      WBInteraction000501862
      WBInteraction000501909
      WBInteraction000502660
      WBInteraction000502661
      WBInteraction000503747
      WBInteraction000505043
      WBInteraction000505411
      WBInteraction000505412
      WBInteraction000505413
      WBInteraction000505414
      WBInteraction000505415
      WBInteraction000505416
      WBInteraction000517470
      WBInteraction000518572
      WBInteraction000518575
      WBInteraction000520746
      WBInteraction000532881
      WBInteraction000532882
      WBInteraction000532883
      WBInteraction000534570
      WBInteraction000534641
      WBInteraction000534769
      WBInteraction000534770
      WBInteraction000534771
      WBInteraction000534772
      WBInteraction000534773
      WBInteraction000534774
      WBInteraction000534775
      WBInteraction000534776
      WBInteraction000534887
      WBInteraction000535319
      WBInteraction000538893
      WBInteraction000540568
      WBInteraction000541039
      WBInteraction000541080
      WBInteraction000541081
      WBInteraction000541082
      WBInteraction000542815
      WBInteraction000550332
      WBInteraction000550435
      WBInteraction000550451
      WBInteraction000550457
      WBInteraction000550482
      WBInteraction000550487
      WBInteraction000550492
      WBInteraction000550496
      WBInteraction000550499
      WBInteraction000550501
      WBInteraction000550503
      WBInteraction000550508
      WBInteraction000550578
      WBInteraction000550584
      WBInteraction000550612
      WBInteraction000550614
      WBInteraction000550617
      WBInteraction000550621
      WBInteraction000550626
      WBInteraction000550628
      WBInteraction000550630
      WBInteraction000550667
      WBInteraction000556363
      WBInteraction000556364
      WBInteraction000556365
      WBInteraction000556366
      WBInteraction000558166
      WBInteraction000567992
      WBInteraction000573508
      WBInteraction000579142
      WBInteraction000579143
      WBInteraction000579326
      WBInteraction000582466
      WBInteraction000532884
    WBProcess: WBbiopr:00000017
  Map_info: Map: V Position: 1.40307 Error: 0.003599
    Positive: Positive_clone: F52E1 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4596
    Pseudo_map_position
  Reference (132)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene