WormBase Tree Display for Gene: WBGene00004789

WBGene00004789 SMap: S_parent: Sequence: W10G6
  Identity: Version: 1
    Name: CGC_name: sgk-1 Person_evidence: WBPerson50
      Sequence_name: W10G6.2
      Molecular_name: W10G6.2a
        W10G6.2a.1
        CE39527
        W10G6.2b
        CE39528
        W10G6.2a.2
        W10G6.2b.1
      Other_name: tag-74 CGC_data_submission
        CELE_W10G6.2 Accession_evidence: NDB BX284606
      Public_name: sgk-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sgk
    Allele (164)
    Strain: WBStrain00003895
      WBStrain00023654
      WBStrain00023656
      WBStrain00035695
      WBStrain00048359
    RNASeq_FPKM (74)
    GO_annotation (39)
    Ortholog (43)
    Paralog (15)
    Structured_description: Concise_description: sgk-1 encodes a serine/threonine protein kinase that is orthologous to the mammalian serum- and glucocorticoid-inducible kinases (SGKs); in C. elegans, sgk-1 activity is required for normal egg laying, generation time, stress response, and adult life span; SGK-1 forms a complex with the AKT kinases with which it functions in parallel to mediate certain aspects of DAF-2/insulin-signaling; SGK-1 phosphorylates DAF-16 in vitro in a manner strictly dependent upon pdk-1 which encodes a 3-phosphoinositide-dependent kinase; an SGK-1::GFP fusion protein is expressed beginning in late embryonic stages and in larvae is seen in sensory and motor neurons as well as in the intestine; in neurons SGK-1::GFP localizes to the cytoplasm and the nucleus, while in the intestine SGK-1::GFP is found exclusively in the cytoplasm. Paper_evidence: WBPaper00013413
          Curator_confirmed: WBPerson1843
          Date_last_updated: 12 Oct 2007 00:00:00
      Automated_description: Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in several processes, including mesendoderm development; positive regulation of vitellogenesis; and regulation of protein localization to basolateral plasma membrane. Located in cytoplasm and nucleus. Expressed in intestine; neurons; and tail neurons. Human ortholog(s) of this gene implicated in cystadenocarcinoma (multiple); granulosa cell tumor; and hypertension. Is an ortholog of human C8orf44-SGK3 (C8orf44-SGK3 readthrough); SGK2 (serum/glucocorticoid regulated kinase 2); and SGK3 (serum/glucocorticoid regulated kinase family member 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3603 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10810)
      DOID:2999 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10810)
      DOID:3114 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10810)
      DOID:10763 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10810)
  Molecular_info: Corresponding_CDS: W10G6.2a
      W10G6.2b
    Corresponding_CDS_history: W10G6.2:wp152
    Corresponding_transcript: W10G6.2a.1
      W10G6.2a.2
      W10G6.2b.1
    Other_sequence (65)
    Associated_feature: WBsf654686
      WBsf671425
      WBsf671426
      WBsf671427
      WBsf238384
  Experimental_info: RNAi_result (44)
    Expr_pattern: Expr2920
      Expr12360
      Expr13383
      Expr13384
      Expr1028504
      Expr1032376
      Expr1158648
      Expr2015802
      Expr2034035
    Drives_construct: WBCnstr00000182
      WBCnstr00020685
      WBCnstr00022723
      WBCnstr00035387
      WBCnstr00039281
      WBCnstr00039282
    Construct_product: WBCnstr00000182
      WBCnstr00017996
      WBCnstr00020685
      WBCnstr00035387
    Antibody: WBAntibody00001662
    Microarray_results (23)
    Expression_cluster (140)
    Interaction: WBInteraction000002409
      WBInteraction000002411
      WBInteraction000002412
      WBInteraction000002413
      WBInteraction000002414
      WBInteraction000003906
      WBInteraction000003907
      WBInteraction000009332
      WBInteraction000009425
      WBInteraction000009500
      WBInteraction000009521
      WBInteraction000009722
      WBInteraction000028521
      WBInteraction000028690
      WBInteraction000030254
      WBInteraction000032701
      WBInteraction000032837
      WBInteraction000032923
      WBInteraction000032935
      WBInteraction000034213
      WBInteraction000034566
      WBInteraction000035047
      WBInteraction000035535
      WBInteraction000036375
      WBInteraction000036567
      WBInteraction000037415
      WBInteraction000038027
      WBInteraction000038135
      WBInteraction000038136
      WBInteraction000039233
      WBInteraction000039813
      WBInteraction000040634
      WBInteraction000041335
      WBInteraction000041740
      WBInteraction000043584
      WBInteraction000043747
      WBInteraction000044334
      WBInteraction000044335
      WBInteraction000045508
      WBInteraction000046392
      WBInteraction000046426
      WBInteraction000046513
      WBInteraction000046514
      WBInteraction000046769
      WBInteraction000047018
      WBInteraction000047397
      WBInteraction000047474
      WBInteraction000048468
      WBInteraction000049673
      WBInteraction000049818
      WBInteraction000049847
      WBInteraction000050025
      WBInteraction000050090
      WBInteraction000050380
      WBInteraction000050381
      WBInteraction000050908
      WBInteraction000050919
      WBInteraction000102685
      WBInteraction000108786
      WBInteraction000109396
      WBInteraction000110582
      WBInteraction000110777
      WBInteraction000110948
      WBInteraction000111086
      WBInteraction000112163
      WBInteraction000112201
      WBInteraction000112333
      WBInteraction000112447
      WBInteraction000112545
      WBInteraction000112549
      WBInteraction000112639
      WBInteraction000112692
      WBInteraction000112978
      WBInteraction000113484
      WBInteraction000114873
      WBInteraction000114998
      WBInteraction000115848
      WBInteraction000117562
      WBInteraction000119083
      WBInteraction000119880
      WBInteraction000120020
      WBInteraction000120054
      WBInteraction000120116
      WBInteraction000120326
      WBInteraction000120903
      WBInteraction000121118
      WBInteraction000139067
      WBInteraction000142015
      WBInteraction000146214
      WBInteraction000162176
      WBInteraction000162984
      WBInteraction000165462
      WBInteraction000165621
      WBInteraction000165644
      WBInteraction000166239
      WBInteraction000173791
      WBInteraction000173792
      WBInteraction000197024
      WBInteraction000224415
      WBInteraction000226580
      WBInteraction000238367
      WBInteraction000247765
      WBInteraction000251824
      WBInteraction000254704
      WBInteraction000255973
      WBInteraction000255977
      WBInteraction000259908
      WBInteraction000272091
      WBInteraction000278549
      WBInteraction000278551
      WBInteraction000285474
      WBInteraction000290698
      WBInteraction000291912
      WBInteraction000298829
      WBInteraction000310315
      WBInteraction000322154
      WBInteraction000329963
      WBInteraction000334765
      WBInteraction000334766
      WBInteraction000337540
      WBInteraction000346740
      WBInteraction000361290
      WBInteraction000393276
      WBInteraction000420234
      WBInteraction000422696
      WBInteraction000468663
      WBInteraction000468761
      WBInteraction000469268
      WBInteraction000470686
      WBInteraction000471695
      WBInteraction000473011
      WBInteraction000475351
      WBInteraction000501232
      WBInteraction000501233
      WBInteraction000501240
      WBInteraction000501241
      WBInteraction000501619
      WBInteraction000501620
      WBInteraction000501621
      WBInteraction000504984
      WBInteraction000517752
      WBInteraction000517753
      WBInteraction000517755
      WBInteraction000517756
      WBInteraction000517758
      WBInteraction000517759
      WBInteraction000517775
      WBInteraction000517777
      WBInteraction000517781
      WBInteraction000517782
      WBInteraction000517785
      WBInteraction000517786
      WBInteraction000517789
      WBInteraction000517790
      WBInteraction000518024
      WBInteraction000519489
      WBInteraction000519490
      WBInteraction000519495
      WBInteraction000519496
      WBInteraction000519497
      WBInteraction000519498
      WBInteraction000520446
      WBInteraction000520447
      WBInteraction000520448
      WBInteraction000520449
      WBInteraction000521032
      WBInteraction000521036
      WBInteraction000524499
      WBInteraction000525342
      WBInteraction000525343
      WBInteraction000525344
      WBInteraction000525345
      WBInteraction000525347
      WBInteraction000525348
      WBInteraction000525349
      WBInteraction000537332
      WBInteraction000537333
      WBInteraction000537334
      WBInteraction000537335
      WBInteraction000537338
      WBInteraction000537339
      WBInteraction000537340
      WBInteraction000537348
      WBInteraction000537358
      WBInteraction000537359
      WBInteraction000537360
      WBInteraction000537361
      WBInteraction000537362
      WBInteraction000537365
      WBInteraction000537366
      WBInteraction000537368
      WBInteraction000537371
      WBInteraction000540185
      WBInteraction000541271
      WBInteraction000541289
      WBInteraction000542844
      WBInteraction000542857
      WBInteraction000542863
      WBInteraction000542864
      WBInteraction000542987
      WBInteraction000556542
      WBInteraction000556543
      WBInteraction000556547
      WBInteraction000560375
      WBInteraction000560376
      WBInteraction000560377
      WBInteraction000560378
      WBInteraction000560379
      WBInteraction000560380
      WBInteraction000560381
      WBInteraction000560382
      WBInteraction000560383
      WBInteraction000561333
      WBInteraction000562610
      WBInteraction000562611
      WBInteraction000564276
    WBProcess: WBbiopr:00000001
      WBbiopr:00000039
      WBbiopr:00000074
  Map_info: Map: X Position: 23.6985 Error: 0.006601
    Positive: Positive_clone: W10G6 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4658
    Pseudo_map_position
  Reference (96)
  Remark: Gene name created from parsing 'genotype' field from CGC strain information CGC_data_submission
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene