WormBase Tree Display for Gene: WBGene00000050

WBGene00000050 SMap: S_parent: Sequence: D2092
  Identity: Version: 1
    Name: CGC_name: acr-11 Person_evidence: WBPerson1430
      Sequence_name: D2092.3
      Molecular_name: D2092.3
        D2092.3.1
        CE09102
      Other_name: CELE_D2092.3 Accession_evidence: NDB BX284601
      Public_name: acr-11
    DB_info: Database: AceView gene 1H198
        WormQTL gene WBGene00000050
        WormFlux gene WBGene00000050
        NDB locus_tag CELE_D2092.3
        Panther gene CAEEL|WormBase=WBGene00000050|UniProtKB=P91197
          family PTHR18945
        NCBI gene 191599
        RefSeq protein NM_059505.2
        TrEMBL UniProtAcc P91197
        UniProt_GCRP UniProtAcc P91197
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acr
    Allele (45)
    Strain: WBStrain00031963
    RNASeq_FPKM (74)
    GO_annotation (32)
    Ortholog: WBGene00056134 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00033600 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00148482 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00141041 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            WormBase-Compara
      WBGene00090088 Pristionchus pacificus From_analysis: OMA
            WormBase-Compara
      WBGene00222941 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g9615 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g4811 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g7129 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g11131 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g9621 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g12116 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g14884 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g14885 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g25382 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g25383 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g17615 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g5606 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g5609 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g14324 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g5197 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g6070 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cnig_chr_I.g2508 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g14675 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00687.g14422 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_17444 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_001806 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g06002 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g15761 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10333400 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g1205 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00133290 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00238131 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00238252 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00119191 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00263566 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00290200 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0086778 Drosophila melanogaster From_analysis: OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      FB:FBgn0032151 Drosophila melanogaster From_analysis: OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-040108-3 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-090313-161 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:1960 Homo sapiens From_analysis: OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:15781 Homo sapiens From_analysis: OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:99779 Mus musculus From_analysis: OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2348 Rattus norvegicus From_analysis: OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog (100)
    Structured_description: Concise_description: A homolog of an alpha type nicotinic acetylcholine receptor subunit involved in the mediation of fast synaptic transmission at neuromuscular junctions. Paper_evidence: WBPaper00005223
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable acetylcholine receptor activity; excitatory extracellular ligand-gated monoatomic ion channel activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in chemical synaptic transmission. Predicted to be located in neuron projection and synapse. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; carcinoma (multiple); and inflammatory bowel disease (multiple). Is an ortholog of human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3748 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:8778 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3083 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:12217 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:8577 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:7474 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:5419 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
  Molecular_info: Corresponding_CDS: D2092.3
    Corresponding_transcript: D2092.3.1
    Other_sequence: JI482048.1
      JO468908.1
      Acan_isotig17242
      JI177628.1
      JI182272.1
    Associated_feature: WBsf649250
      WBsf219611
  Experimental_info: RNAi_result: WBRNAi00043516 Inferred_automatically: RNAi_primary
      WBRNAi00102757 Inferred_automatically: RNAi_primary
      WBRNAi00113432 Inferred_automatically: RNAi_primary
      WBRNAi00003293 Inferred_automatically: RNAi_primary
      WBRNAi00066390 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1023679
      Expr1147510
      Expr2009179
      Expr2027418
    Drives_construct: WBCnstr00037768
    Construct_product: WBCnstr00037768
    Microarray_results (18)
    Expression_cluster (62)
    Interaction: WBInteraction000163500
      WBInteraction000211264
      WBInteraction000232397
      WBInteraction000387314
      WBInteraction000392230
      WBInteraction000411228
      WBInteraction000441842
      WBInteraction000457445
  Map_info: Map: I Position: 1.25616 Error: 0.003426
    Positive: Positive_clone: D2092 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4955
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene