WormBase Tree Display for Gene: HGNC:1960
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| HGNC:1960 | Identity | Name | CGC_name | Chrna7 | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Other_name (12) | ||||||
| Public_name | Chrna7 | |||||
| DB_info | Database | HGNC | id | 1960 | ||
| AGR | cURI | HGNC:1960 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSG00000175344 | ||||
| ENSG00000274542 | ||||||
| ENSG00000282088 | ||||||
| UniProt | UniProt_AC | P36544 | ||||
| DO | id | DOID:10652 | ||||
| DOID:3908 | ||||||
| DOID:3748 | ||||||
| DOID:8778 | ||||||
| DOID:3083 | ||||||
| DOID:12217 | ||||||
| DOID:8577 | ||||||
| DOID:1324 | ||||||
| DOID:7474 | ||||||
| DOID:5419 | ||||||
| Species | Homo sapiens | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog | WBGene00000046 | Caenorhabditis elegans | From_analysis | OMA | ||
| OrthoFinder | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| WBGene00001133 | Caenorhabditis elegans | From_analysis | OrthoFinder | |||
| Panther | ||||||
| PhylomeDB | ||||||
| WBGene00000055 | Caenorhabditis elegans | From_analysis | Hieranoid | |||
| OMA | ||||||
| OrthoFinder | ||||||
| OrthoInspector | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| SonicParanoid | ||||||
| WBGene00000048 | Caenorhabditis elegans | From_analysis | OrthoFinder | |||
| Panther | ||||||
| PhylomeDB | ||||||
| SonicParanoid | ||||||
| WBGene00000049 | Caenorhabditis elegans | From_analysis | OrthoFinder | |||
| Panther | ||||||
| PhylomeDB | ||||||
| WBGene00000050 | Caenorhabditis elegans | From_analysis | OMA | |||
| OrthoFinder | ||||||
| OrthoInspector | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| SonicParanoid | ||||||
| WBGene00000053 | Caenorhabditis elegans | From_analysis | OrthoFinder | |||
| Panther | ||||||
| PhylomeDB | ||||||
| WBGene00000054 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | |||
| OrthoFinder | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| WBGene00000058 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | |||
| Inparanoid | ||||||
| OrthoFinder | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| WBGene00043066 | Caenorhabditis elegans | From_analysis | OrthoFinder | |||
| OrthoInspector | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| SonicParanoid | ||||||
| Structured_description | Automated_description | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] | Inferred_automatically | AGR_import |
