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WormBase Tree Display for Gene: WBGene00000793

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WBGene00000793	Evidence	Accession_evidence	EMBL	AB081595
	SMap	S_parent	Sequence	Y41C4A
	Identity	Version	1
		Name	CGC_name	crh-1	Person_evidence	WBPerson268
			Sequence_name	Y41C4A.4
			Molecular_name (21)
			Other_name	CELE_Y41C4A.4	Accession_evidence	NDB	BX284603
			Public_name	crh-1
		DB_info	Database	AceView	gene	3M781
				WormQTL	gene	WBGene00000793
				WormFlux	gene	WBGene00000793
				NDB	locus_tag	CELE_Y41C4A.4
				Panther	gene	CAEEL\|WormBase=WBGene00000793\|UniProtKB=D0Z5N1
					family	PTHR45879
				NCBI	gene	176597
				RefSeq	protein	NM_001027688.6
						NM_001027691.4
						NM_001027690.4
						NM_001268206.3
						NM_001027689.3
						NM_001027692.4
						NM_001268207.3
				SwissProt	UniProtAcc	Q9U2I0
				TREEFAM	TREEFAM_ID	TF106464
				UniProt_GCRP	UniProtAcc	Q9U2I0
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:21	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	crh
		Allele (986)
		Strain	WBStrain00040751
			WBStrain00035398
			WBStrain00055558
		RNASeq_FPKM (74)
		GO_annotation (18)
		Ortholog	WBGene00063063	Caenorhabditis remanei	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00034037	Caenorhabditis briggsae	From_analysis	Hillier-set
						OrthoMCL
						OMA
						Inparanoid_8
						WormBase-Compara
			WBGene00153718	Caenorhabditis brenneri	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00122954	Caenorhabditis japonica	From_analysis	TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00226771	Brugia malayi	From_analysis	WormBase-Compara
			CBOVI.g5739	Caenorhabditis bovis	From_analysis	WormBase-Compara
			CSP21.g1140	Caenorhabditis parvicauda	From_analysis	WormBase-Compara
			CSP26.g6305	Caenorhabditis zanzibari	From_analysis	WormBase-Compara
			CSP28.g8449	Caenorhabditis panamensis	From_analysis	WormBase-Compara
			CSP29.g11281	Caenorhabditis becei	From_analysis	WormBase-Compara
			CSP31.g21071	Caenorhabditis uteleia	From_analysis	WormBase-Compara
			CSP32.g4874	Caenorhabditis sulstoni	From_analysis	WormBase-Compara
			CSP38.g7777	Caenorhabditis quiockensis	From_analysis	WormBase-Compara
			CSP40.g20592	Caenorhabditis tribulationis	From_analysis	WormBase-Compara
			Cang_2012_03_13_00281.g8415	Caenorhabditis angaria	From_analysis	WormBase-Compara
			Cni-crh-1	Caenorhabditis nigoni	From_analysis	WormBase-Compara
			Csp11.Scaffold488.g1997	Caenorhabditis tropicalis	From_analysis	WormBase-Compara
			Csp5_scaffold_00412.g11007	Caenorhabditis sinica	From_analysis	WormBase-Compara
			FL83_17624	Caenorhabditis latens	From_analysis	WormBase-Compara
			GCK72_010254	Caenorhabditis remanei	From_analysis	WormBase-Compara
			OTIPU.nOt.2.0.1.g11644	Oscheius tipulae	From_analysis	WormBase-Compara
			Pan_g6977	Panagrellus redivivus	From_analysis	WormBase-Compara
			Sp34_30095300	Caenorhabditis inopinata	From_analysis	WormBase-Compara
			chrIII_pilon.g9070	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00244541	Onchocerca volvulus	From_analysis	WormBase-Compara
			WBGene00114226	Pristionchus pacificus	From_analysis	WormBase-Compara
			WBGene00263440	Strongyloides ratti	From_analysis	WormBase-Compara
			WBGene00294169	Trichuris muris	From_analysis	WormBase-Compara
			WBGene00296439	Trichuris muris	From_analysis	WormBase-Compara
			WBGene00296712	Trichuris muris	From_analysis	WormBase-Compara
			FB:FBgn0265784	Drosophila melanogaster	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			ZFIN:ZDB-GENE-030131-4334	Danio rerio	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			ZFIN:ZDB-GENE-050417-150	Danio rerio	From_analysis	EnsEMBL-Compara
						OrthoFinder
						Panther
			ZFIN:ZDB-GENE-050417-355	Danio rerio	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			ZFIN:ZDB-GENE-030131-7031	Danio rerio	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			ZFIN:ZDB-GENE-040426-750	Danio rerio	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			HGNC:783	Homo sapiens	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			HGNC:2345	Homo sapiens	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			HGNC:2352	Homo sapiens	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			MGI:1298366	Mus musculus	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			MGI:88494	Mus musculus	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			MGI:88495	Mus musculus	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			RGD:2402	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			RGD:620218	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			RGD:1307360	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
		Paralog	WBGene00000222	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00002783	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00016162	Caenorhabditis elegans	From_analysis	WormBase-Compara
		Structured_description	Concise_description	crh-1 encodes a homolog of the cyclic AMP-response element binding protein (CREB); crh-1 is involved in the transcription of CRE-sequence dependant genes activated by a CaM kinase cascade; crh-1 is required in the bilateral thermosensory neuron AFD, for a memory-related behaviour and for response to tap (nonlocalized mechanosensory stimulation) and tap habituation; crh-1 appears to be ubiquitously expressed.	Paper_evidence	WBPaper00005563
						WBPaper00029055
						WBPaper00039855
						WBPaper00039821
					Curator_confirmed	WBPerson1843
						WBPerson324
					Date_last_updated	02 Dec 2013 00:00:00
			Automated_description	Enables identical protein binding activity and transcription coactivator binding activity. Involved in determination of adult lifespan; intracellular signal transduction; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Expressed in several structures, including germ line; gonad; head ganglion; intestine; and neurons. Human ortholog(s) of this gene implicated in Pick's disease and schizophrenia. Is an ortholog of human ATF1 (activating transcription factor 1); CREB1 (cAMP responsive element binding protein 1); and CREM (cAMP responsive element modulator).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model	DOID:9976	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2345)
			DOID:0050741	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2345)
			DOID:11870	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2345)
			DOID:9975	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2345)
			DOID:5419	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2345)
	Molecular_info	Corresponding_CDS (7)
		Corresponding_CDS_history	Y41C4A.4a:wp89
			Y41C4A.4b:wp89
			Y41C4A.4c:wp89
		Corresponding_transcript	Y41C4A.4a.1
			Y41C4A.4b.1
			Y41C4A.4c.1
			Y41C4A.4d.1
			Y41C4A.4e.1
			Y41C4A.4f.1
			Y41C4A.4g.1
		Other_sequence (69)
		Associated_feature (43)
		Transcription_factor	WBTranscriptionFactor000257
	Experimental_info	RNAi_result	WBRNAi00056358	Inferred_automatically	RNAi_primary
			WBRNAi00095782	Inferred_automatically	RNAi_primary
			WBRNAi00036995	Inferred_automatically	RNAi_primary
			WBRNAi00006490	Inferred_automatically	RNAi_primary
			WBRNAi00116042	Inferred_automatically	RNAi_primary
			WBRNAi00115794	Inferred_automatically	RNAi_primary
			WBRNAi00056360	Inferred_automatically	RNAi_primary
			WBRNAi00087890	Inferred_automatically	RNAi_primary
			WBRNAi00006495	Inferred_automatically	RNAi_primary
		Expr_pattern (12)
		Drives_construct	WBCnstr00008257
			WBCnstr00012859
			WBCnstr00038398
			WBCnstr00038399
			WBCnstr00041558
		Construct_product (13)
		Regulate_expr_cluster	WBPaper00038172:crh-1null_down_regulated
			WBPaper00038172:crh-1null_up_regulated
			WBPaper00059816:crh-1(n3315)_downrgulated
			WBPaper00059816:crh-1(n3315)_uprgulated
			WBPaper00062440:crh-1(n3315)_downregulated
			WBPaper00062440:crh-1(n3315)_upregulated
			WBPaper00062440:crh-1(syb385)_downregulated
			WBPaper00062440:crh-1(syb385)_upregulated
		Antibody	WBAntibody00001853
		Microarray_results (61)
		Expression_cluster (111)
		Interaction (63)
		WBProcess	WBbiopr:00000121
	Map_info	Map	III	Position	11.752	Error	0.036866
		Positive	Positive_clone	Y41C4A	Inferred_automatically	From CDS info
						From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	4239
				4497
		Pseudo_map_position
	Reference (94)
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene